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Expert to Discuss Middleman in Protein Synthesis

Tuesday, March 6, 2007

Eric Phizicky, Ph.D., professor of Biochemistry & Biophysics, will give a talk titled tRNA: how and why it’s all dressed up as part of a lecture series highlighting biomedical research at the University of Rochester.

Phizicky will speak about the tremendous, recent explosion in the understanding of transfer ribonucleic acid (tRNA), the middleman in the process of converting genetic code into proteins that make up the body’s structures, carry its messages and execute its functions. He will speak at 4 p.m. Friday, March 9, in the Case Methods Room (Room 1-9576) at the Medical Center.

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Irina Chernyakov Receives GWIS Travel and Conference Award

Thursday, June 1, 2006

Irina Chernyakov, a 3rd year graduate student in Dr. Eric Phizicky's lab received a travel and conference award from GWIS. She attended and presented a poster at the annual RNA Society Meeting in Seattle, Washington. View her Travel report followup.

Study to Explore Cellular Circuitry

Wednesday, September 7, 2005

As part of a $4.88 million grant from the National Science Foundation (NSF), molecular biologists from the University of Rochester Medical Center will join a team seeking to create the first complete wiring diagram of a living cell. By wiring diagram, researchers mean a detailed model, not only of the cell’s genes and their function, but also of the interplay between them. When complete, the diagram has the potential to reveal cellular approaches to treating many diseases, including cancer.

With most genes redundant and related to other genes and proteins in predictable ways, we can begin to identify the function of unknown cellular players based on their neighbors and associates, said Eric Phizicky, Ph.D., professor of Biochemistry & Biophysics at the medical center. That puts us within reach of a completed diagram and the ability to re-wire cells in the treatment of disease.

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Wilmot Cancer Center Honors Scientists Pioneering Genomic Research

Thursday, November 18, 2004

A pair of scientists whose discoveries have changed genomic research was honored today by the James P. Wilmot Cancer Center at the University of Rochester Medical Center. Eric Phizicky, Ph.D., and Elizabeth Grayhack, Ph.D., received the 2004 Davey Memorial Award for outstanding contributions to cancer research.

Phizicky and Grahack, a husband-and-wife research team, are considered pioneers in the field of functional proteomics. They were the first to develop a method to identify genes by the activity of their products on a genome-wide scale, by using all of the 6,144 genes of yeast as a model system. Their work has broad implications for biological sciences including cancer research.

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Martha Wilkinson Receives GWIS Travel and Conference Award

Thursday, July 1, 2004

Martha Wilkinson, a 5th year graduate student in Dr. Eric Phizicky's lab received a travel and conference award from GWIS. She attended and presented a poster at the Yeast Genomics Meeting in Seattle, Washington.

Eric Phizicky Discusses Probing Protein Function on a Genomic Scale

Monday, May 12, 2003

Eric Phizicky, Ph.D., professor in the department of Biochemistry & Biophysics at the University of Rochester was interviewed and profiled at GenomeWeb. Dr. Phizicky discussed his research at the University Rochester, the library of 6,144 yeast strains, and the fact that his lab has identified genes, in the last four years, associated with more than 38 activities, including just about every biochemical reaction.

Read More: Eric Phizicky Discusses Probing Protein Function on a Genomic Scale

Bio Online Presents: Panel of Scientists Deciphering the Human Proteome

Friday, March 9, 2001

The completion of the first draft of the human genome sequence gives us the potential to understand the precise protein content of every cell in a human being. It is also suddenly within our sights to decipher the function of every protein in the cell, and a number of methods have emerged to meet this challenge.

The Phizicky lab has focused on a genomic approach to biochemical analysis. To this end, a genomic library of yeast strains was prepared, in which each strain expresses a different yeast protein attached to an affinity purification tag. With the purified genomic array of proteins, one can rapidly link any biochemical activity to its cognate gene. This array has been used to identify several different catalytic and binding activities, and can be used to find targets of drugs. A similar array could be developed to analyze the proteins of the human genome.