p75 Neurotrophin Receptor Signaling and Trafficking -
A Role in Protection Against Oxidant Stress in Neurons
p75NTR is known to have protective effects against oxidant stress in some cells. Dr. Schor and her lab have found that p75NTR-deficient PC12 pheochromocytoma cells are unable to handle oxidative stress. The lab is now studying the mechanism by which p75NTR protects the cell, with a focus on the intracellular domain (ICD) and its localization to the mitochondria. Using expression constructs of variably sized fragments of p75ICD labeled with a visualization tag, PC12 cells will be transfected and p75ICD trafficking followed to understand the role of this p75NTR cleavage product in resistance to oxidative stress.
University of Rochester Medical Center
Wilmot Cancer Institute
601 Elmwood Avenue
Rochester, NY 14642