URMC / Labs / Sime Lab / Publications Publications Lacy SHEpa APPollock SJWoeller CFThatcher THPhipps RPSime PJ (2017 Dec 20). Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2. American journal of physiology. Lung cellular and molecular physiology. Duffney PFMcCarthy CENogales AThatcher THMartinez-Sobrido LPhipps RPSime PJ (2017 Dec 14). Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage. American journal of physiology. Lung cellular and molecular physiology. Jackson TCZhang YVSime PJPhipps RPKottmann RM (2017 Jul 24). Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. Jenkins RGMoore BBChambers RCEickelberg OKönigshoff MKolb MLaurent GJNanthakumar CBOlman MAPardo ASelman MSheppard DSime PJTager AMTatler ALThannickal VJWhite ES (2017 May). An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. Yee MDomm WGelein RBentley KLKottmann RMSime PJLawrence BPO'Reilly MA (2017 Apr). Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells. American journal of respiratory cell and molecular biology. Kim NThatcher THSime PJPhipps RP (2017 Feb 09). Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients. JCI insight. McCarthy CEDuffney PFGelein RThatcher THElder APhipps RPSime PJ (2016 Dec 01). Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology. Walker DIPennell KDUppal KXia XHopke PKUtell MJPhipps RPSime PJRohrbeck PMallon CTJones DP (2016 Aug). Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. Woeller CFThatcher THVan Twisk DPollock SJCroasdell AHopke PKXia XThakar JSime PJMallon TMUtell MJPhipps RP (2016 Aug). MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. Croasdell ASime PJPhipps RP (2016 Jun 2). Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Croasdell ALacy SHThatcher THSime PJPhipps RP (2016 Mar 15). Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. Journal of immunology (Baltimore, Md. : 1950). Kim NRamon SThatcher THWoeller CFSime PJPhipps RP (2016 Jan). Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production. European journal of immunology. Thatcher THWilliams MAPollock SJMcCarthy CELacy SHPhipps RPSime PJ (2016 Jan). Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function. Immunology. Kottmann RMTrawick EJudge JLWahl LAEpa APOwens KMThatcher THPhipps RPSime PJ (2015 Dec 1). Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. American journal of physiology. Lung cellular and molecular physiology. Hsiao HMThatcher THColas RASerhan CNPhipps RPSime PJ (2015 Dec). Resolvin D1 Reduces Emphysema and Chronic Inflammation. The American journal of pathology. Yao HSundar IKHuang YGerloff JSellix MTSime PJRahman I (2015 Dec). Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology. Judge JLOwens KMPollock SJWoeller CFThatcher THWilliams JPPhipps RPSime PJKottmann RM (2015 Oct 15). Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. American journal of physiology. Lung cellular and molecular physiology. Croasdell AThatcher THKottmann RMColas RADalli JSerhan CNSime PJPhipps RP (2015 Oct 15). Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. American journal of physiology. Lung cellular and molecular physiology. Jeon KIPhipps RPSime PJHuxlin KR (2015 Jul 1). Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. Experimental eye research. Kottmann RMSharp JOwens KSalzman PXiao GQPhipps RPSime PJBrown EBPerry SW (2015 May 27). Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung. Respiratory research. Jones KMRandtke EAHowison CMCárdenas-Rodríguez JSime PJKottmann MRPagel MD (2015 Apr). Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. Epa APThatcher THPollock SJWahl LALyda EKottmann RMPhipps RPSime PJ (2015). Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2. PloS one. Croasdell ADuffney PFKim NLacy SHSime PJPhipps RP (2015). PPARγ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR research. Hsiao HMThatcher THLevy EPFulton RAOwens KMPhipps RPSime PJ (2014 Nov 15). Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. Journal of immunology (Baltimore, Md. : 1950). Lugade AABogner PNThatcher THSime PJPhipps RPThanavala Y (2014 Jun 1). Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. Journal of immunology (Baltimore, Md. : 1950). Thannickal VJHenke CAHorowitz JCNoble PWRoman JSime PJZhou YWells RGWhite ESTschumperlin DJ (2014 Jun). Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. The American journal of pathology. Jeon KIKulkarni AWoeller CFPhipps RPSime PJHindman HBHuxlin KR (2014 May). Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation. The American journal of pathology. Yao HSundar IKAhmad TLerner CGerloff JFriedman AEPhipps RPSime PJMcBurney MWGuarente LRahman I (2014 May 1). SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. American journal of physiology. Lung cellular and molecular physiology. Olsen KCEpa APKulkarni AAKottmann RMMcCarthy CEJohnson GVThatcher THPhipps RPSime PJ (2014 Apr). Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. American journal of respiratory cell and molecular biology. Blackwell TSTager AMBorok ZMoore BBSchwartz DAAnstrom KJBar-Joseph ZBitterman PBlackburn MRBradford WBrown KKChapman HACollard HRCosgrove GPDeterding RDoyle RFlaherty KRGarcia CKHagood JSHenke CAHerzog EHogaboam CMHorowitz JCKing TELoyd JELawson WEMarsh CBNoble PWNoth ISheppard DOlsson JOrtiz LAO'Riordan TGOury TDRaghu GRoman JSime PJSisson THTschumperlin DViolette SMWeaver TEWells RGWhite ESKaminski NMartinez FJWynn TAThannickal VJEu JP (2014 Jan 15). Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. American journal of respiratory and critical care medicine. Sundar IKYao HHuang YLyda ESime PJSellix MTRahman I (2014). Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. PloS one. Rosas IOKottmann RMKottman RMSime PJ (2013 Oct 1). New light is shed on the enigmatic origin of the lung myofibroblast. American journal of respiratory and critical care medicine. Thatcher THHsiao HMPinner ELaudon MPollock SJSime PJPhipps RP (2013 Jul 15). Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. American journal of physiology. Lung cellular and molecular physiology. McMillan DHWoeller CFThatcher THSpinelli SLMaggirwar SBSime PJPhipps RP (2013 Jun 1). Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology. Huxlin KRHindman HBJeon KIBühren JMacRae SDeMagistris MCiufo DSime PJPhipps RP (2013). Topical rosiglitazone is an effective anti-scarring agent in the cornea. PloS one. Hsiao HMSapinoro REThatcher THCroasdell ALevy EPFulton RAOlsen KCPollock SJSerhan CNPhipps RPSime PJ (2013). A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PloS one. Kulkarni AAThatcher THHsiao HMOlsen KCKottmann RMMorrissette JWright TWPhipps RPSime PJ (2013). The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis. PloS one. Ramon SBancos SThatcher THMurant TIMoshkani SSahler JMBottaro ASime PJPhipps RP (2012 Nov 15). Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response. Journal of immunology (Baltimore, Md. : 1950). Kottmann RMKulkarni AASmolnycki KALyda EDahanayake TSalibi RHonnons SJones CIsern NGHu JZNathan SDGrant GPhipps RPSime PJ (2012 Oct 15). Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β. American journal of respiratory and critical care medicine. Davies ERHaitchi HMThatcher THSime PJKottmann RMGanesan APackham GO'Reilly KMDavies DE (2012 May). Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. American journal of respiratory cell and molecular biology. Kuriyan AELehmann GMKulkarni AAWoeller CFFeldon SEHindman HBSime PJHuxlin KRPhipps RP (2012 Jan). Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. Experimental eye research. Kulkarni AAWoeller CFThatcher THRamon SPhipps RPSime PJ (2012). Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases. PPAR research. Reddy RCRehan VKRoman JSime PJ (2012). PPARs: Regulators and Translational Targets in the Lung. PPAR research. Rico de Souza AZago MPollock SJSime PJPhipps RPBaglole CJ (2011 Dec 16). Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. The Journal of biological chemistry. Blumberg NSime PJPhipps RP (2011 Oct). The mystery of transfusion-related acute lung injury. Transfusion. Olsen KCSapinoro REKottmann RMKulkarni AAIismaa SEJohnson GVThatcher THPhipps RPSime PJ (2011 Sep 15). Transglutaminase 2 and its role in pulmonary fibrosis. American journal of respiratory and critical care medicine. Kottmann RMKelly JLyda EGurell MStalica JOrmsby WMoon KTrawick DSime PJ (2011 Sep). Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients. Thorax. McMillan DHBaglole CJThatcher THMaggirwar SSime PJPhipps RP (2011 Jul). Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation. The American journal of pathology. Lin XSime PJXu HWilliams MALaRussa LGeoras SNGuo J (2011 Jun 15). Yin yang 1 is a novel regulator of pulmonary fibrosis. American journal of respiratory and critical care medicine. Xi XMcMillan DHLehmann GMSime PJLibby RTHuxlin KRFeldon SEPhipps RP (2011 Jun). Ocular fibroblast diversity: implications for inflammation and ocular wound healing. Investigative ophthalmology & visual science.