Welcome to the Yang Lab
We study the structure and function of ion channels, and how dysfunction or dysregulation of ion channels causes human diseases. Our current focus is on two families of Ca2+-activated Cl- channels (CaCC), namely BESTROPHINs and TMEM16s. Malfunction of these channels has been linked to devastating consequences such as vision loss, heart failure and cancer, underlying their great potential as pharmaceutical targets. As a multidisciplinary research team, we employ a combination of electrophysiological (patch clamp and lipid bilayer), structural (cryo-EM and X-ray crystallography), cellular (stem cell technology and confocal imaging) and genetic (CRISPR/Cas9-mediated genome editing) approaches.
On-going projects include: