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News

20172016

Department holiday party!

Tuesday, December 12, 2017

holiday dept party

Yang lab holiday lunch. Wishing everyone another prosperous and productive year!

Tuesday, December 12, 2017

holiday lunch

Changyi patched her first cell. Congratulations!

Tuesday, December 5, 2017

Welcome Changyi to join the lab!

Friday, December 1, 2017

Congratulations to Austin for recording his first lipid bilayer trace!

Tuesday, October 24, 2017

Reversing Retinal Degenerative Diseases: We're One Step Closer

Tuesday, October 24, 2017

Degenerative disorders affecting the retinal pigment epithelium (RPE), such as age-related macular degeneration and autosomal recessive bestrophinopathy, can ultimately lead to blindness. Some of these life-changing disorders are the result of mutations in a single gene, called BEST1.

Although the genetic defect in BEST1 was identified almost two decades ago, its physiological role—how it does what it does, was unclear. Now, researchers from Columbia University and University of Rochester have used a novel approach to solve this mystery. Today, they published their pioneering study in the journal eLife

The researchers created a “disease-in-a-dish,” meaning that they coaxed skin cells taken from an adult patient first back into an embryonic-like state (called induced pluripotent stem cells, or iPSCs) and then into RPE cells to create a model of retinal degenerative disease. Then they assessed physiological properties of the RPE cells carrying normal or mutated BEST1 via innovative, interdisciplinary approaches to pinpoint the exact role of the BEST1 gene.

The researchers were also able to show that RPE cells that carry the BEST1 gene mutations, which are the same cells that are damaged by degenerative diseases, can have their damage reversed by providing healthy copies of the BEST1 gene (through viral gene supplementation, which uses a specially selected virus to “carry” new genes into the cells).

“Our team provided evidence that autosomal recessive bestrophinopathy is a ‘chloride channelopathy’ and is a treatable disorder,” said RPB Physician-Scientist Awardee Stephen H. Tsang, MD, PhD, Associate Professor of Ophthalmology and Associate Professor of Pathology and Cell Biology at Columbia University, and Tingting Yang, PhD, Assistant Professor of Pharmacology and Physiology at University of Rochester.

Read More: Reversing Retinal Degenerative Diseases: We're One Step Closer

Our first research paper is accepted by eLife.

Wednesday, September 13, 2017

Our first research paper “Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca2+-dependent Cl- currents in human RPE” is accepted in eLife. Great team effort! Now the pathological potential of BEST1 mutations can be evaluated and predicted with our iPSC-based 'disease-in-a-dish' approach. Congratulations to Yu, Alec and Nancy!

Welcome Austin to begin in the lab!

Friday, September 8, 2017

Welcome Sunny to stay with us for the new school year!

Wednesday, August 30, 2017

Alec got his first crystal! Congratulations!

Tuesday, August 15, 2017

Sunny and Laura join us for the summer. Welcome!

Friday, June 2, 2017

Alec received his B.S. degree from UR. Congratulations!

Tuesday, May 23, 2017