URMC / Labs / Yang Lab / Publications Recent Publications Li YZhang YXu YKittredge AWard NChen STsang SHYang T (2017 Oct 24). Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca(2+)-dependent Cl(-) currents in human RPE. eLife. Yang TColecraft HM (2016). Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels. Channels (Austin, Tex.). Yang TJustus SLi YTsang SH (2015 Dec). BEST1: the Best Target for Gene and Cell Therapies. Molecular therapy : the journal of the American Society of Gene Therapy. Yang THendrickson WAColecraft HM (2014 Dec 23). Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels. Proceedings of the National Academy of Sciences of the United States of America. Yang TLiu QKloss BBruni RKalathur RCGuo YKloppmann ERost BColecraft HMHendrickson WA (2014 Oct 17). Structure and selectivity in bestrophin ion channels. Science (New York, N.Y.). Yang TColecraft HM (2013 Jul). Regulation of voltage-dependent calcium channels by RGK proteins. Biochimica et biophysica acta. Yang THe LLChen MFang KColecraft HM (2013). Bio-inspired voltage-dependent calcium channel blockers. Nature communications. Yang TPuckerin AColecraft HM (2012). Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels. PloS one. Yang TXu XKernan TWu VColecraft HM (2010 May 15). Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase. The Journal of physiology. Yang TSuhail YDalton SKernan TColecraft HM (2007 Dec). Genetically encoded molecules for inducibly inactivating CaV channels. Nature chemical biology.