Recent Publications

• 1. Kittredge A
  2. Ji C
  3. Zhang Y
  4. Yang T
  Differentiation, Maintenance, and Analysis of Human Retinal Pigment Epithelium Cells: A Disease-in-a-dish Model for BEST1 Mutations.; Journal of visualized experiments : JoVE. 2018 Aug 24.
• 1. Zhang Y
  2. Kittredge A
  3. Ward N
  4. Ji C
  5. Chen S
  6. Yang T
  ATP activates bestrophin ion channels through direct interaction.; Nature communications; Vol 9(1). 2018 Aug 07.
• 1. Kittredge A
  2. Ward N
  3. Hopiavuori A
  4. Zhang Y
  5. Yang T
  Expression and Purification of Mammalian Bestrophin Ion Channels.; Journal of visualized experiments : JoVE. 2018 Aug 02.
• 1. Li Y
  2. Zhang Y
  3. Xu Y
  4. Kittredge A
  5. Ward N
  6. Chen S
  7. Tsang SH
  8. Yang T
  Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca(2+)-dependent Cl(-) currents in human RPE.; eLife; Vol 6. 2017 Oct 24.
• 1. Yang T
  2. Colecraft HM
  Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels.; Channels (Austin, Tex.); Vol 10(1). 2016.
• 1. Yang T
  2. Justus S
  3. Li Y
  4. Tsang SH
  BEST1: the Best Target for Gene and Cell Therapies.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 23(12). 2015 Dec.
• 1. Yang T
  2. Hendrickson WA
  3. Colecraft HM
  Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.; Proceedings of the National Academy of Sciences of the United States of America; Vol 111(51). 2014 Dec 23.
• 1. Yang T
  2. Liu Q
  3. Kloss B
  4. Bruni R
  5. Kalathur RC
  6. Guo Y
  7. Kloppmann E
  8. Rost B
  9. Colecraft HM
  10. Hendrickson WA
  Structure and selectivity in bestrophin ion channels.; Science (New York, N.Y.); Vol 346(6207). 2014 Oct 17.
• 1. Yang T
  2. Colecraft HM
  Regulation of voltage-dependent calcium channels by RGK proteins.; Biochimica et biophysica acta; Vol 1828(7). 2013 Jul.
• 1. Yang T
  2. He LL
  3. Chen M
  4. Fang K
  5. Colecraft HM
  Bio-inspired voltage-dependent calcium channel blockers.; Nature communications; Vol 4. 2013.
• 1. Yang T
  2. Puckerin A
  3. Colecraft HM
  Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.; PloS one; Vol 7(5). 2012.
• 1. Yang T
  2. Xu X
  3. Kernan T
  4. Wu V
  5. Colecraft HM
  Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.; The Journal of physiology; Vol 588(Pt 10). 2010 May 15.
• 1. Yang T
  2. Suhail Y
  3. Dalton S
  4. Kernan T
  5. Colecraft HM
  Genetically encoded molecules for inducibly inactivating CaV channels.; Nature chemical biology; Vol 3(12). 2007 Dec.