URMC / Labs / Yang Lab / Publications Recent Publications Zhang YKittredge AWard NJi CChen SYang T ATP activates bestrophin ion channels through direct interaction.; Nature communications; Vol 9(1). 2018 Aug 07. Kittredge AWard NHopiavuori AZhang YYang T Expression and purification of mammalian Bestrophin ion channels.; Journal of visualized experiments : JoVE. 2018 Jan 01. Kittredge AJi CZhang YYang T Differentiation, maintenance and analysis of human retinal pigment epithelium cells: a disease-in-a-dish model for BEST1 mutations.; Journal of visualized experiments : JoVE. 2018 Jan 01. Li YZhang YXu YKittredge AWard NChen STsang SHYang T Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca(2+)-dependent Cl(-) currents in human RPE.; eLife; Vol 6. 2017 Oct 24. Yang TColecraft HM Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels.; Channels (Austin, Tex.); Vol 10(1). 2016. Yang TJustus SLi YTsang SH BEST1: the Best Target for Gene and Cell Therapies.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 23(12). 2015 Dec. Yang THendrickson WAColecraft HM Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.; Proceedings of the National Academy of Sciences of the United States of America; Vol 111(51). 2014 Dec 23. Yang TLiu QKloss BBruni RKalathur RCGuo YKloppmann ERost BColecraft HMHendrickson WA Structure and selectivity in bestrophin ion channels.; Science (New York, N.Y.); Vol 346(6207). 2014 Oct 17. Yang TColecraft HM Regulation of voltage-dependent calcium channels by RGK proteins.; Biochimica et biophysica acta; Vol 1828(7). 2013 Jul. Yang THe LLChen MFang KColecraft HM Bio-inspired voltage-dependent calcium channel blockers.; Nature communications; Vol 4. 2013. Yang TPuckerin AColecraft HM Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.; PloS one; Vol 7(5). 2012. Yang TXu XKernan TWu VColecraft HM Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.; The Journal of physiology; Vol 588(Pt 10). 2010 May 15. Yang TSuhail YDalton SKernan TColecraft HM Genetically encoded molecules for inducibly inactivating CaV channels.; Nature chemical biology; Vol 3(12). 2007 Dec.