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Host Machineries Regulating HIV Transcription and Latency

Land and Linehan

HIV latency and reactivation.

Host machineries regulating HIV transcription and latency. Through the comprehensive functional genomic screens, we identified host proteins that potently suppress HIV transcription and promote its latency, including BRD4 and FACT (SUPT16H and SSRP1) proteins. We are currently investigating the molecular functions of these HIV latency-promoting genes (LPGs) in resting CD4+ T cells. Meanwhile, we are exploring the application of bromodomain inhibitors as novel HIV latency-reversing agents (LRAs) to reverse HIV latency and eliminate residual latent viral reservoirs for a cure. We are also interested in using newly-emerged functional genomic tools to identify novel and significant LPGs.

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