Systems Biology Tools To Study Host-Virus Interaction: Development And Use Of Proteomics
Proteomics for viral proteins.
To understand host-virus relationships, it is indispensable to globally study their protein interactions since viruses usually encode limited genes and highly depend on host machineries to replicate. Host antiviral proteins may also directly bind with viral proteins and antagonize their activity. We developed and employed several novel proteomic tools to fulfill our interests in studying host-virus protein interactions, including protein array and PLATO (Parallel Analysis of in vitro Translated ORFs) technologies. PLATO is currently being used for identifying novel host-virus protein interactions for our "favorite" viruses (HIV, EBV, and KSHV).
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