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Irfan Rahman Named ATS Fellow

Wednesday, October 31, 2018

Irfan Rahman, Ph.D., professor of environmental medicine, public health sciences, dentistry and medicine has been designated as an American Thoracic Society Fellow for his pulmonary science accomplishments and services to international lung community.

Dr. Rahman's lab is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Congratulations Irfan!

Former Tox Student Claire McCarthy, PhD Featured on NPR

Thursday, October 18, 2018

McCarthy

Early one morning in the spring of 2017, former Toxicology graduate student Claire McCarthy (Sime Lab) started her day as many don't: rolling dried rhinoceros dung into cigarettes and packing them into a machine that smoked them.

Although it might seem bizarre, McCarthy's purpose was serious: She wanted to know what happens when people breathe in dung smoke.

Dung smoke is no joke. Animal dung is used by millions globally for heating and cooking.

It's a dangerous practice. Burning biomass fuels (including animal dung as well as wood, charcoal, and plant matter) generates indoor air pollution, which caused 4 million deaths worldwide in 2012 according to the World Health Organization. Like cigarette smoke, biomass smoke has been linked to increased risk of lung diseases, such as chronic obstructive pulmonary disorder (COPD), lung cancer and respiratory infection.

Read More: Former Tox Student Claire McCarthy, PhD Featured on NPR

Roswell Park and URMC to Create $19 Million Research Program Focused on Flavored Tobacco

Friday, September 21, 2018

The expertise of two regional research teams has earned a federal grant of nearly $20 million to create the nation's first program dedicated to the study of flavored tobacco. One of only nine projects to earn funding through the federal Tobacco Centers of Regulatory Science (TCORS) program, the WNY Center for Research on Flavored Tobacco Products, or CRoFT, will unite teams from Roswell Park Comprehensive Cancer Center and the University of Rochester Medical Center in an effort to better document and understand one of the fastest-growing trends in tobacco use.

The five-year, $19.05 million competitive grant, awarded by the National Cancer Institute, will be shared by Roswell Park and URMC. Based at Roswell Park, the program will be led by Richard O'Connor, Ph.D., and Maciej Goniewicz, Ph.D., Pharm.D., both internationally recognized experts on tobacco use and its health consequences. The Roswell Park team will analyze various combustible and electronic tobacco products, their consequences for health and how users interact with these products. Collaborators from URMC, led by Irfan Rahman, Ph.D., and Deborah Ossip, Ph.D., will contribute critical resources in biomarker screening, genetic analysis and toxicology assessment.

"We're really excited about initiating this work, because no one has ever looked at flavored tobacco in such a comprehensive and systematic way. There are so many different flavorings, delivery systems and product options, and so much we don't know about them," says O'Connor, professor of Oncology with Roswell Park's Health Behavior and Epidemiology & Prevention programs and director of the Buffalo cancer center's Tobacco Research Laboratory.

Current federal regulations prohibit the sale and manufacture of flavors other than menthol in combustible cigarettes but not in other tobacco products, including e-cigarettes. Data published last year from the PATH Study, the largest prospective U.S. study of tobacco use, indicated that use of flavored products was highest among youth and young-adult tobacco users, with 80% of tobacco users ages 12-17 and 73% of tobacco users ages 18-24 reporting that they'd used a flavored tobacco product in the previous 30 days.

"There are a number of flavoring chemicals that are regarded as safe for incorporation into food and drink, but we have such limited data about what happens when these products are inhaled," adds Rahman, professor of Environmental Medicine, Dentistry, Medicine (Pulmonary) and Public Health Sciences at URMC. "We're going to study the impact on public health when these chemicals are added to e-cigarettes, vape pens, Juul and other pods, hookahs, waterpipes, cigars and cigarillos (little cigars) to be a resource for both policymakers and the general public."

Read More: Roswell Park and URMC to Create $19 Million Research Program Focused on Flavored Tobacco

Is Vaping Safer Than Smoking?

Thursday, March 15, 2018

After e-cigarettes first emerged in 2004, they quickly became a popular, "healthier" alternative for those who wanted the feeling of smoking tobacco. This could be one of the reasons for the steady, continued decline of cigarette smoking in the United States. While nearly 42 percent of the population were smokers during the Mad Men era of the mid-60s, the figure dropped to around 17 percent in recent years.

While studies acknowledge vaping has far less of an impact on health compared to smoking, experts also cautioned long-term studies still can't make solid conclusions as the alternative has been in use for only a little more than a decade. Growing evidence from research, however, suggested we are just beginning to see the potential consequences.

In 2015, a letter from the New England Journal of Medicine expressed concern over formaldehyde, a toxic compound found in the vapors produced by e-cigarettes. While researchers are still studying its link to cancer, formaldehyde is known to cause irritation to the skin, eyes, nose, and throat.

Irfan Rahman, professor of Environmental Medicine at the University of Rochester, led the first study to examine the impact of e-cigarettes on oral health.

"We showed that when the vapors from an e-cigarette are burned, it causes cells to release inflammatory proteins, which in turn aggravate stress within cells, resulting in damage that could lead to various oral diseases," he said.

This year, he was one of the authors of a study that examined artificial flavors for inducing tissue damage and having a toxic effect on white blood cells, with the worst impact coming from cinnamon, vanilla, and buttery flavored e-juices. There are around 250 harmful chemicals found in traditional cigarettes while the number is significantly reduced in vaping. But the presence of nicotine still poses a threat (particularly risk of heart disease) in its concentrated, e-liquid form.