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John Looney Lab

R. John Looney, M.D.

M.D. 1976
University of Rochester School of Medicine and Dentistry

Dr. Stephen I. Rosenfeld and Elise A. Rosenfeld Distinguished Professorship in Allergy & Clinical Immunology

Professor of Medicine

Division of Allergy/Immunology and Rheumatology

Professor of Environmental Medicine

Research Overview

Dr. Looney is the Stephen and Elise Rosenfeld Distinguished Professor of Allergy and Clinical Immunology. He is a Rheumatologist and Allergy/Clinical Immunologist with active clinical practices in both of these specialties. Since the mid-1990’s his primary research interest has been the development of new treatments for Rheumatologic diseases. In the late 1990’s he began developing one of the very first clinical trials testing B cell targeted therapy, rituximab (anti-DC20), in human autoimmune diseases, an approach which has proven remarkably successful for a number of autoimmune diseases. This trial also led to groundbreaking work on the effects of B cell depletion therapy on B cell subsets helped establish the central themes of our division’s research for the past decade. From 2003 to 2014 he has been on the steering committee for the Autoimmunity Centers of Excellence (ACE) and has been the Clinical Director for the Rochester Autoimmunity Centers of Excellence. Since 2001 he has been the Director of our grant from the Lupus Clinical Trials Consortium which provides funding for lupus clinical trials infrastructure. Dr. Looney has also been the Director of Allergy and Clinical Immunology Program since 2001 and has an active research program in Allergy/Clinical Immunology evaluating the role of the microbiome (bacteria and fungi) in preventing the development of allergic disease.