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NIAMS Update Features AIR Research

Thursday, September 1, 2016

AIR researchers at the University of Rochester Medical Center have been studying how B cells contribute to bone loss in rheumatoid arthritis (RA). As described in the September issue of NIAMS Update, this research provides information on new ways to approach treatments in people with RA.

AIR Researchers Demonstrate Role for B Cells in Bone Erosion in RA

Thursday, April 14, 2016

AIR researchers have uncovered a new mechanism of bone erosion and a possible biomarker for rheumatoid arthritis (RA). The group is the first to demonstrate that immune cells, called B cells, contribute directly to the breakdown of bone in RA by producing a signaling molecule called RANKL.

Read More: AIR Researchers Demonstrate Role for B Cells in Bone Erosion in RA

Christopher Ritchlin, MD, MPH Awarded RO1 to Study DC-STAMP as a Regulator of Osteoclastogenesis and Response Marker in PsA

Tuesday, March 1, 2016

Dr. Christopher Ritchlin's research will address how DC-STAMP promotes OC genesis and inflammation, analyze if 1A2 inhibits synovitis and damage; and investigate if DC-STAMP is an early response biomarker in PsA. Results from these studies will provide insights into key mechanisms that underlie inflammatory arthritis and bone damage in the psoriatic joint and will catalyze biomarker discovery. Importantly, it is expected that the results will reveal therapeutic targets in the DC-STAMP signaling pathway with potential to impede pathologic bone degradation in PsA, osteoporosis and other inflammatory bone and joint disorders.

Ananta Paine, PhD Awarded the Department of Medicine Research Pilot Grant

Friday, January 1, 2016

Study name: “Identification of the key dynamic networks that regulate osteoclastogenesis using high throughput molecular profiling, network analysis and mathematical modeling.”

Ananta Paine, PhD Receives the Health Sciences Center for Computational Innovation Pilot Award

Friday, January 1, 2016

Study name: “Identification of the key dynamic networks that regulate osteoclastogenesis using high throughput molecular profiling, network analysis and mathematical modeling.”