John Looney Lab R. John Looney, M.D. View Dr. Looney's profile M.D. 1976 University of Rochester School of Medicine and Dentistry Dr. Stephen I. Rosenfeld and Elise A. Rosenfeld Distinguished Professorship in Allergy & Clinical Immunology Professor of Medicine Division of Allergy/Immunology and Rheumatology Professor of Environmental Medicine Research Overview Dr. Looney is the Stephen and Elise Rosenfeld Distinguished Professor of Allergy and Clinical Immunology. He is a Rheumatologist and Allergy/Clinical Immunologist with active clinical practices in both of these specialties. Since the mid-1990’s his primary research interest has been the development of new treatments for Rheumatologic diseases. In the late 1990’s he began developing one of the very first clinical trials testing B cell targeted therapy, rituximab (anti-DC20), in human autoimmune diseases, an approach which has proven remarkably successful for a number of autoimmune diseases. This trial also led to groundbreaking work on the effects of B cell depletion therapy on B cell subsets helped establish the central themes of our division’s research for the past decade. From 2003 to 2014 he has been on the steering committee for the Autoimmunity Centers of Excellence (ACE) and has been the Clinical Director for the Rochester Autoimmunity Centers of Excellence. Since 2001 he has been the Director of our grant from the Lupus Clinical Trials Consortium which provides funding for lupus clinical trials infrastructure. Dr. Looney has also been the Director of Allergy and Clinical Immunology Program since 2001 and has an active research program in Allergy/Clinical Immunology evaluating the role of the microbiome (bacteria and fungi) in preventing the development of allergic disease. Select Publications RJ Looney, GN Abraham, CL Anderson. Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J Immunol 136:1641-1647, 1986. PubMed PMID: 2936805. Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol 90: 213-219, 1999. PubMed PMID: 10080833. Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I. B Cell Depletion as a Novel Treatment for Systemic Lupus Erythematosus: A Phase I/II Dose-escalation Trial of rituximab. Arthritis and Rheumatism. 50(8):2580-9, 2004. PubMed PMID: 15334472. Looney RJ, Diamond B, Holers M, Levesque M, Moreland L, Nahm M, St. Clair W. Autoimmunity Centers of Excellence Guidelines for Assessing Immunocompetency in Clinical Trials for Autoimmune Diseases. Clinical Immunology 123(3):235-43, 2007. PubMed PMID: 17329169. Looney R.J., Srinivasan R, Calabrese LH. The Effects of Rituximab on Immunocompetency in Patient with Autoimmune Disease. (review) Arthritis and Rheumatism 58:5-14, 2008. PubMed PMID: 18163518.