Regulation of Gene Expression by Targeted Degradation of RNA
Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research
Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.
Type Three Secretion System mediated pathogenesis of V. cholerae
Regulation of macrophage function in innate immunity
Differentiation of CD4 T lymphocytes in infectious and autoimmune disease
Immunity to Tumor Antigens.
Microbial pathogens and the impact of human microbial flora on human health and disease.
Infections in the immunocompromised host, mechanisms of pathogenesis, host-microbe interactions and approaches to therapy
Antimicrobial Susceptibility and Resistance.
Dynamic regulation of leukocyte adhesion and migration
Cell Mediated Immunity to Tumors
Platelets, HIV, and inflammation
Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
Molecular and cellular events that regulate T cell signaling and activation
The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity
Biosynthesis of the Cell Wall of Mycobacterium tuberculosis; Biodefense Research
The bacterium, Streptococcus mutans, which colonizes the human mouth from the time of tooth eruption until death.
Using a comparative biology approach to advance immunotoxicology, leveraging the amphibian Xenopus and the pox-like ranavirus FV3, to address long-term effects of water pollutants on immune cell development and on antiviral immunity across the lifespan.
Influenza specific immunity, vaccine design and regulation of T cell responses to pathogens.
Molecular Mechanisms of Paramyxovirus Infection, Replication and Assembly
Identification of immune signatures and characterization of dynamics of immune responses by using systems biology approaches.
Conducting clinical and translational research on respiratory pathogens, immunity, and infectious disease, including the study of environmental factors that affect immune responses to influenza and vaccination, seeking new approaches to enhance immunity, reduce pathology, and prevent disease.
Molecular Mechanisms of Poxvirus Envelope Formation
Innate immunity, Host-microbial interactions, Immunoparasitology, Mucosal immunology
Host-virus interactions, particularly for HIV and herpes viruses