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Pilot Funding

This Pilot Studies program is funded by the University of Rochester Core Center for Musculoskeletal Biology and Medicine’s (P30) NIH Award. The renewal of this award was submitted to NIH in June, 2015, with an outcome expected in the Spring 2016. Although we have a favorable Impact Score, applicants should note that funds for this Pilot Studies program are predicated upon successful competitive renewal of our P30 application.

Based on our optimism that the P30 will be renewed, the University of Rochester Core Center for Musculoskeletal Biology and Medicine is now requesting applications from investigators from New Investigators for funding of pilot projects. Investigator-initiated pilot studies for fulltime faculty who are either Physician-Scientists, Research Assistant Professors or Assistant Professors who have not received NIH R01 or equivalent grant funding as a Principal Investigator are eligible to apply for research funding relevant to Musculoskeletal Diseases ($25,000 maximum for one year).

All principal investigators of proposals must be faculty at the University of Rochester. Co-investigators may be from other institutions. Funding cannot be used to support faculty salary. Trainee salary support is permitted but must be justified in the proposal. Renewal of funding of investigator-initiated pilots for a second year may be possible under special circumstances where considered justified, and revised applications from prior Requests for Proposals may be submitted. Concurrent funding of more than a single pilot award to an investigator from the URCCMBM is not permitted.

The pilot grant program is intended to provide seed funding to facilitate new research and future funding. Multidisciplinary research is strongly encouraged, as well as translational and clinical research that moves new discoveries along the translational continuum to humans and the community. Clinical and community based research, practice-based research, and health services research proposals are also encouraged.

Proposal Submission

A face page application form and investigator’s proposal (in a modified NIH format with a 6 page maximum, 11-point font minimum) and budget form with a budget justification should be submitted electronically by email to Bonnie_Lipari@urmc.rochester.edu; phone: (585) 273-5635.

Deadlines

Proposals must be received by Friday, February 26, 2016.

Applicants will be notified of awards by May 1, 2016, which will be initiated immediately. The funding must be expended by June 30, 2017.

Note: All animal and human subject protocols must be approved prior to the start date. No funds will be released until these approvals have been documented.

Please see the full announcement for more details

URCCMBM Pilot Awardees

Date Awardee Title
2016-2017 John Elfar, MD 4AP To Prevent Muscle Atrophy after Peripheral Nerve Injury
2016-2017 Jennifer Jonason, PhD The Role of RUNX2 in the Progression of Post-Traumatic Osteoarthritis
2016-2017 Catherine Kuo, PhD Axial and Limb Tendon Progenitor Cell Baseline and FGF4-Induced Differences
2016-2017 Hengwei Zhang, PhD Proteasome inhibition enhanced bone fracture healing through PDGFRb signaling
2015-2016 Reyad Elbarbary, PhD Regulation of Adiopogenesis by Tudor-SN-mediated miRNA Decay: Implications in Obesity-impaired Fracture Healing
2015-2016 Roman Eliseev, MD, PhD Effect of cyclophilin D knock-out on bone loss after hormone depletion
2015-2016 Benjamin Frisch, PhD The role of CCL3 in Leukemia-induced osteolineage Dysfunction
2015-2016 David Weber, MD Assessment of Calcium Metabolism in Adolescents with Type 1 Diabetes Using a Dual Stale Calcium Isotopes Method
2014-2015 Mark Buckley, PhD Defining the Role of Mechanical Compression in Insertional Achilles Tendinopathy
2014-2015 John Daiss, PhD Diagnosis and Monitoring of Ongoing Staphylococcus aureus Infections Using Circulating Cell-Free Bacterial DNA and Circulating Antibody-Secreting Cells
2014-2015 Tzong-jen Sheu, PhD Cobalt In Rlease Alters Skeletal Metabolism: A Mechanism for Bone Loss in Metal-on-Metal Orthopaedic Implants
2014-2015 Hengwei Zhang, MD Proteasome inhibitor VELCADE enhances bone fracture healing by inhibiting ubiquitination and degradation of ostoblast positive regulators in callus
2013-2014 Yufeng Dong, MD, PhD Clinical grade expansion of functional Mesenchymal stem cells from human bone marrow in cGMP facility
2013-2014 Zhenqiang Yao, MD TRAF3 levels in Blood Monocytes in Rheumatoid Arthritis
2013-2014 Luiz Meirelles, DDS, PhD Novel free radicals therapeutic device to treat implant associated osteomyelitis
2013-2014 Wakenda Tyler, MD, MPH MicroRNA impact on Angiogenesis & Tumor Growth in Metastatic Renal Cancer to Bone
2012-2013 John Daiss, PhD Targeted Lytic Agents for the Prevention and Elimination of Staphylococcus aureus Infections
2012-2013 Yufeng Dong, MD Assessment of skeletal stromal cell sheets for repair of critical segmented bone defects
2012-2013 Roman Eliseev, MD, PhD Targeting metabolic reprogramming in osteosarcoma
2012-2013 Yi Zhang, PhD MEm1/m1 mouse as a potential model for Scheuermann disease
2012-2013 Michael Maloney, MD Correlation of vascular and anatomical response with structural and clinical outcome: a pilot study in patients who have undergone rotator cuff repair surgery
2011-2012 Stephen Kates, MD Evaluation of Anti-Autolysin titers against S. aureus in Patients with Infected Total Joint Replacements and Development o a Clinical Serum ELISA to Assess the Probability of Reinfection
2011-2012 Jennifer Jonason, PhD Examination of the Effects of Chondrocyte-specific Runx2 Overexpression on Endochondral Bone Formation and Postnatal Articular Cartilage Homeostasis
2011-2012 Chao Xie, MD PTH Effects on Intravenously Delivered hMSC during Skeletal Repair
2011-2012 Zhenqiang Yao, MD The Role of NF-kB relB in Fracture Healing

Louis A. Goldstein and Mildred M. Goldstein Orthopaedic Research Award

Each year faculty members are encouraged to apply for The Goldstein Award. This endowment gifted by Louis A. Goldstein and Mildred M. Goldstein is for funding of clinical Orthopaedic research. This gift enables faculty to generate pilot data from which they can apply for additional funding.

Goldstein Awardees

Date Awardee Title
2015 John Elfar, MD Erythropoietin for Compression Neuropathy: Preclinical Efficacy and Cellular Site of Action
2015 Irvin Oh, MD Clinical Applicability of Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Staphylococcus aureus Infections in Diabetic Foot Ulcer
2014 Addisu Mesfin, MD Reducing Dysphagia Following Anterior Cervical Spine Surgery: A prospective Randomized Double-Blind Placebo Trial
2014 Brian D. Gioardno, MD The influence of periarticular hip dysfunction on the progression of osteoarthritis
2013 Gregg Nicandri MD and Stephen Kates, MD The Development, Implementation and Validatio of an Orthopaedic Surgical Skills Curriculum: A Pilot Study Focusing on the Treatment of Hip Fractures with a Dynamic Hop Scrw or Trochanteric Femoral Nail and the Treatment of Meniscal Tears of the Knee with Arthroscopic Partial Menisectomy
2012 Benedict DiGiovanni, MD and Deborah A. Nawoczenski, PT, PhD Biomechanical and Muscle morphological Biomarkers of Foot Function Following Gastrocnemius Recession for Achilles Tendinopathy
2011 John Elfar, MD Parathyroid Hormone in Rotator Cuff Tears