University of Rochester Core Center for Musculoskeletal Biology and Medicine
This Pilot Studies program is funded by the University of Rochester Core Center for Musculoskeletal Biology and Medicine’s (P30) NIH Award. The renewal of this award was submitted to NIH in June, 2015, with an outcome expected in the Spring 2016. Although we have a favorable Impact Score, applicants should note that funds for this Pilot Studies program are predicated upon successful competitive renewal of our P30 application.
Based on our optimism that the P30 will be renewed, the University of Rochester Core Center for Musculoskeletal Biology and Medicine is now requesting applications from investigators from New Investigators for funding of pilot projects. Investigator-initiated pilot studies for fulltime faculty who are either Physician-Scientists, Research Assistant Professors or Assistant Professors who have not received NIH R01 or equivalent grant funding as a Principal Investigator are eligible to apply for research funding relevant to Musculoskeletal Diseases ($25,000 maximum for one year).
All principal investigators of proposals must be faculty at the University of Rochester. Co-investigators may be from other institutions. Funding cannot be used to support faculty salary. Trainee salary support is permitted but must be justified in the proposal. Renewal of funding of investigator-initiated pilots for a second year may be possible under special circumstances where considered justified, and revised applications from prior Requests for Proposals may be submitted. Concurrent funding of more than a single pilot award to an investigator from the URCCMBM is not permitted.
The pilot grant program is intended to provide seed funding to facilitate new research and future funding. Multidisciplinary research is strongly encouraged, as well as translational and clinical research that moves new discoveries along the translational continuum to humans and the community. Clinical and community based research, practice-based research, and health services research proposals are also encouraged.
A face page application form and investigator’s proposal (in a modified NIH format with a 6 page maximum, 11-point font minimum) and budget form with a budget justification should be submitted electronically by email to Bonnie_Lipari@urmc.rochester.edu (phone: 585-273-5635).
Proposals must be received by Friday, February 26, 2016.
Applicants will be notified of awards by May 1, 2016, which will be initiated immediately. The funding must be expended by June 30, 2017.
All animal and human subject protocols must be approved prior to the start date. No funds will be released until these approvals have been documented.
URCCMBM PILOT AWARDEES
|2015-2016||Reyad Elbarbary, PhD||Regulation of Adiopogenesis by Tudor-SN-mediated miRNA Decay: Implications in Obesity-impaired Fracture Healing|
|2015-2016||Roman Eliseev, MD, PhD||Effect of cyclophilin D knock-out on bone loss after hormone depletion|
|2015-2016||Benjamin Frisch, PhD||The role of CCL3 in Leukemia-induced osteolineage Dysfunction|
|2015-2016||David Weber, MD||Assessment of Calcium Metabolism in Adolescents with Type 1 Diabetes Using a Dual Stale Calcium Isotopes Method|
|2014-2015||Mark Buckley, PhD||Defining the Role of Mechanical Compression in Insertional Achilles Tendinopathy|
|2014-2015||John Daiss, PhD||Diagnosis and Monitoring of Ongoing Staphylococcus aureus Infections Using Circulating Cell-Free Bacterial DNA and Circulating Antibody-Secreting Cells|
|2014-2015||Tzong-jen Sheu, PhD||Cobalt In Rlease Alters Skeltal Metabolism: A Mechanism for Bone Loss in Metal-on-Metal Orthopaedic Implants|
|2014-2015||Hengwei Zhang, MD||Proteasome inhibitor VELCADE enhances bone fracture healing by inhibiting ubiquitination and degradation of ostoblast positive reulgators in callus|
|2013-2014||Yufeng Dong, MD, PhD||Clinical grade expansion of functional Mesenchymal stem cells from human bone marrow in cGMP facility|
|2013-2014||Zhenqiang Yao, MD||TRAF3 levels in Blood Monocytes in Rheumatoid Arthritits|
|2013-2014||Luiz Meirelles, DDS, PhD||Novel free radicals therapeutic device to treat implant associated osteomyelitis|
|2013-2014||Wakenda Tyler, MD, MPH||MicroRNA impact on Angiogenesis & Tumor Growth in Metastatic Renal Cancer to Bone|
|2012-2013||John Daiss, PhD||Targeted Lytic Agents for the Prevention and Elimination of Staphylococcus aureus Infections|
|2012-2013||Yufeng Dong, MD||Assessment of skeletal stromal cell sheets for repair of critical segmented bone defects|
|2012-2013||Roman Eliseev, MD, PhD||Targeting metabolic reprogramming in osteosarcoma|
|2012-2013||Yi Zhang, PhD||MEm1/m1 mouse as a potential model for Scheuermann disease|
|2012-2013||Michael Maloney, MD||Correlatin of vascular and anatomical response with structural and clinical outcome: a pilot study in patients who have undergone rotator cuff repair surgery|
|2011-2012||Stephen Kates, MD||Evaluation of Anti-Autolysin titers against S. aureus in Patients with Infected Total Joint Replacements and Development o a Clinical Serum ELISA to Assess the Probability of Reinfection|
|2011-2012||Jennifer Jonason, PhD||Examination of the Effects of Chondrocyte-specific Runx2 Overexpression on Endochondral Bone Formation and Postnatal Articular Cartilage Homeostasis|
|2011-2012||Chao Xie, MD||PTH Effects on Intravenously Delivered hMSC during Skeletal Repair|
|2011-2012||Zhenqiang Yao, MD||The Role of NF-kB relB in Fracture Healing|
Louis A. Goldstein and Mildred M. Goldstein Orthopaedic Research Award
Each year faculty members are encouraged to apply for The Goldstein Award. This endowment gifted by Louis A. Goldstein and Mildred M. Goldstein is for funding of clinical Orthopaedic research. This gift enables faculty to generate pilot data from which they can apply for additional funding.
|2015||John Elfar, MD||Erythropoietin for Compression Neuropathy: Preclinical Efficacy and Cellular Site of Action|
|2015||Irvin Oh, MD||Clinical Applicability of Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Staphylococcus aureus Infections in Diabetic Foot Ulcer|
|2014||Addisu Mesfin, MD||Reducing Dysphagia Following Anterior Cervical Spine Surgery: A prospective Randomized Double-Blind Pacebo Trial|
|2014||Brian D. Gioardno, MD||The influence of periarticular hip dysfunction on the progression of osteoarthritis|
|2013||Gregg Nicandri MD and Stephen Kates, MD||The Development, Implementation and Validatio of an Orthopaedic Surgical Skills Curriculum: A Pilot Study Focusing on the Treatment of Hip Fractures with a Dynamic Hop Scrw or Trochanteric Femoral Nail and the Treatment of Meniscal Tears of the Knee with Arthroscopic Partial Menisectomy|
|2012||Benedict DiGiovanni, MD and Deborah A. Nawoczenski, PT, PhD||Biomechanical and Muscle morphological Biomarkers of Foot Function Following Gastrocnemius Recession for Achilles Tendinopathy|
|2011||John Elfar, MD||Parathyroid Hormone in Rotator Cuff Tears|
- Dr. Catherine K. Kuo receives Award for Innovation in Research
December 21, 2015
- CTSI Success Story: Pilot Awardee Xinping Zhang
December 21, 2015
- Study Finds Link Between Rare Genetic Mutation and Osteoporosis
October 30, 2015
- Maquat Receiving Canada's Top Prize for Biomedical Research
October 27, 2015
- Nanoparticle-mediated drug delivery could help prevent tendon adhesions
October 16, 2015
- Center for Musculoskeletal Research helps young faculty hone grant proposals
October 9, 2015
- Wilmot Cancer Institute's Research Director Wins $6.3M Outstanding Investigator Awad
September 17, 2015
- Funding Bonanza at CMSR Shows Strategic Planning Pays Off
September 15, 2015
- Danielle Benoit Recognized as a 2015 Young Innovator of Cellular and Molecular Bioengineering
August 11, 2015
- 5th Annual CMSR Symposium - Call for Abstracts
July 7, 2015
- How 3D Printed Bone Grafts Could Combat Bone Infections
May 29, 2015
- Second Year PhD Student, Trombetta, Wins First Prize in the University's Falling Walls Competition
May 22, 2015
- Rubery Named Chair of Orthopaedics
May 1, 2015
February 9, 2016 - Special Lab Meeting (Adolph Auditorium, Rm. 1-7619 (8:30-9:30 am)
Yunpeng Yang - Identification of the effective sources of vascular progenitors for bone tissue engineering
Tao Wang - Electrospun Nanofiber-Based Biomimetic Periosteum for Cranial Bone Defect Repair
February 10, 2016 (Neuman Room, Rm 1-6823 (8:30-9:30 am)
Javier Rangel-Moreno - Small Inhibitors of nuclear export deplete autoreactive
plasma cells in murine lupus
Wen Sun - B cells inhibit osteoblast differentiation in inflammatory arthritis