Pilot Funding

University of Rochester Core Center for Musculoskeletal Biology and Medicine

The University of Rochester Core Center for Musculoskeletal Biology and Medicine (URCCMBM) is requesting applications from New Investigators for funding of pilot projects.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) was awarded a Research Core Center (P30) in musculoskeletal biology and medicine to the University of Rochester. This URCCMBM provides shared facilities and services to groups of established, currently funded investigators addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and ensure greater productivity. It also awards pilot project grants to Physician-Scientists, Research Assistant Professors and Assistant Professors who have not received NIH R01 or equivalent grant funding as Principal Investigator, for research aimed at improving the diagnosis, treatment and prevention of diseases and injuries of the musculoskeletal system and its component tissues. The pilot grant program is intended to provide seed funding to facilitate new research where multidisciplinary research and translational and clinical based research are encouraged among investigators to move toward a common goal of new discoveries along the continuum to humans and the community.

All principal investigators of proposals must be faculty at the University of Rochester.

Proposal Submission:
A face page application form and investigator’s proposal (in a modified NIH format with a 6 page maximum, 11-point font minimum) and budget form with a budget justification should be submitted electronically by email to Bonnie_Lipari@urmc.rochester.edu (phone: 585-273-5635).

Deadlines:
Proposals must be received by February 20, 2015.
Applicants will be notified of awards by May 1, 2015, which will be initiated immediately. The funding must be expended by June 30, 2016.

Note:
All animal and human subject protocols must be approved prior to the start date. No funds will be released until these approvals have been documented.

Please see the full announcement for more details

URCCMBM PILOT AWARDEES

2011-2012 Yufeng Dong, MD, PhD Generation of skeletal stem cell sheets by activation of Notch signaling
2011-2012 Stephen Kates, MD Evaluation of Anti-Autolysin titers against S. aureus in Patients with Infected Total Joint Replacements and Development o a Clinical Serum ELISA to Assess the Probability of Reinfection
2011-2012 Jennifer Jonason, PhD Examination of the Effects of Chondrocyte-specific Runx2 Overexpression on Endochondral Bone Formation and Postnatal Articular Cartilage Homeostasis
2011-2012 Chao Xie, MD PTH Effects on Intravenously Delivered hMSC during Skeletal Repair
2011-2012 Zhenqiang Yao, MD The Role of NF-kB relB in Fracture Healing
2012-2013 Yufeng Dong, MD Assessment of skeletal stromal cell sheets for repair of critical segmented bone defects
2012-2013 John Daiss, PhD Targeted Lytic Agents for the Prevention and Elimination of Staphylococcus aureus Infections
2012-2013 Roman Eliseev, MD, PhD Targeting metabolic reprogramming in osteosarcoma
2012-2013 Yi Zhang, PhD MEm1/m1 mouse as a potential model for Scheuermann disease
2012-2013 Michael Maloney, MD Correlatin of vascular and anatomical response with structural and clinical outcome: a pilot study in patients who have undergone rotator cuff repair surgery
2013-2014 Yufeng Dong, MD, PhD Clinical grade expansion of functional Mesenchymal stem cells from human bone marrow in cGMP facility
2013-2014 Zhenqiang Yao, MD TRAF3 levels in Blood Monocytes in Rheumatoid Arthritits
2013-2014 Luiz Meirelles, DDS, PhD Novel free radicals therapeutic device to treat implant associated osteomyelitis
2013-2014 Wakenda Tyler, MD, MPH MicroRNA impact on Angiogenesis & Tumor Growth in Metastatic Renal Cancer to Bone
2014-2015 Mark Buckley, PhD Defining the Role of Mechanical Compression in Insertional Achilles Tendinopathy
2014-2015 John Daiss, PhD Diagnosis and Monitoring of Ongoing Staphylococcus aureus Infections Using Circulating Cell-Free Bacterial DNA and Circulating Antibody-Secreting Cells
2014-2015 Tzong-jen Sheu, PhD Cobalt In Rlease Alters Skeltal Metabolism: A Mechanism for Bone Loss in Metal-on-Metal Orthopaedic Implants
2014-2015 Hengwei Zhang, MD Proteasome inhibitor VELCADE enhances bone fracture healing by inhibiting ubiquitination and degradation of ostoblast positive reulgators in callus
2015-2016 Reyad Elbarbary, PhD Regulation of Adiopogenesis by Tudor-SN-mediated miRNA Decay: Implications in Obesity-impaired Fracture Healing
2015-2016 Roman Eliseev, MD, PhD Effect of cyclophilin D knock-out on bone loss after hormone depletion
2015-2016 Benjamin Frisch, PhD The role of CCL3 in Leukemia-induced osteolineage Dysfunction
2015-2016 David Weber, MD Assessment of Calcium Metabolism in Adolescents with Type 1 Diabetes Using a Dual Stale Calcium Isotopes Method

Louis A. Goldstein and Mildred M. Goldstein Orthopaedic Research Award

Each year faculty members are encouraged to apply for The Goldstein Award. This endowment gifted by Louis A. Goldstein and Mildred M. Goldstein is for funding of clinical Orthopaedic research. This gift enables faculty to generate pilot data from which they can apply for additional funding.

GOLDSTEIN AWARDEES

2011 Mark Prasarn, MD Unstable Pelvic Ring Injuries: A Comparison of Early Immobilization Techniques
2011 John Elfar, MD Parathyroid Hormone in Rotator Cuff Tears
2012 Benedict DiGiovanni, MD and Deborah A. Nawoczenski, PT, PhD Biomechanical and Muscle morphological Biomarkers of Foot Function Following Gastrocnemius Recession for Achilles Tendinopathy
2013 Gregg Nicandri MD and Stephen Kates, MD The Development, Implementation and Validatio of an Orthopaedic Surgical Skills Curriculum: A Pilot Study Focusing on the Treatment of Hip Fractures with a Dynamic Hop Scrw or Trochanteric Femoral Nail and the Treatment of Meniscal Tears of the Knee with Arthroscopic Partial Menisectomy
2014 Addisu Mesfin, MD Reducing Dysphagia Following Anterior Cervical Spine Surgery: A prospective Randomized Double-Blind Pacebo Trial
2014 Brian D. Gioardno, MD The influence of periarticular hip dysfunction on the progression of osteoarthritis
2015 John Elfar, MD Erythropoietin for Compression Neuropathy: Preclinical Efficacy and Cellular Site of Action
2015 Irvin Oh, MD Clinical Applicability of Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Staphylococcus aureus Infections in Diabetic Foot Ulcer

 

Upcoming Speakers

September 2, 2015
8:30 am - 9:30 am
Neuman Room (Rm 1-6823)

Margaret Thomas - Development of siRNA therapeutics targeting Serpine1 for treatment of tendon adhesions