Welcome to the Chakkalakal Lab
Dr. Joe Chakkalakal is an Assistant Professor in the Department of Orthopaedics, Center for Musculoskeletal Research at the University of Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle.
Through the use of conditional genetic strategies Dr. Chakkalakal's lab has uncovered niche derived signals responsible for age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal's lab is interested in building on these observations to 1) uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging or accelerated aging, and 2) identify therapies that promote resident stem cell maintenance and function.