MSC Self-renewal and Differentiation

Project Overview

Mesenchymal stem cells (MSCs) are multi-potent cells with the capacity to form skeletal tissues including cartilage and bone. Our lab has recently identified the Notch signaling pathway as a key regulator of MSC differentiation and proliferation. We are currently using mouse genetic approaches to identify the mechanisms by which Notch regulates MSC differentiation and expansion during skeletal development. Additionally, we are developing technologies for the isolation and ex vivo maintenance and expansion of human MSCs for use in tissue engineering and skeletal therapeutic applications.


Matthew J. Hilton, Ph.D.
University of Rochester
601 Elmwood Ave., Box 665
Rochester, NY 14642
Office: SMD 1-8535
(585) 275-1335