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Medical Center Expert Publishes Text on Vital Cell Features

Resource Provides New Tools to Researchers in Booming Field

Friday, February 08, 2008

Andrei Ivanov, Ph.D., assistant professor of Medicine at the University of Rochester Medical Center is an editor of a new volume titled “Exocytosis and Endocytosis Methods and Protocols,” part of the prestigious Methods in Molecular Biology series.

Exocytosis is the process used by all cells to move key substances toward the cell’s outer membrane, either to add to the membrane or to be secreted out of the cell. The ability to secrete molecules enables neurons to pass on signals, for instance, and immune cells to trigger counterattacks on invading bacteria and viruses. To move proteins and other molecules, cells form special transport vesicles that protect their cargo as they carry them to their destination. Where exocytosis involves secreting molecules from cells, endocytosis is the process of making outer membrane vesicles to take substances from the environment surrounding a cell into the cell. It too is central to human life, and includes the mechanism through which other immune cells engulf and remove cellular debris and bacteria. 

“Altogether, this makes studying intracellular vesicle trafficking one of the most important topics in basic biology and biomedical science,” said Ivanov, who works within the Gastroenterology and Hepatology Division. “The book represents a collection of research tools, from classic techniques to the cutting edge, which are setting the pace of advancement in this field. Exocytosis and endocytosis are vast areas of research, but as for as I now, this volume is the first specific, methodological guide in this area. It is needed not only for newcomers but also for experts as a reference and troubleshooting source.”

The new text is a part of a well-known book series published by the Humana Press. Those interested can find a description on Humana Press website. At the Medical Center, those interested can check out the book from the Edward G. Miner library.


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