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URMC / News / For Chronic Leukemia Patients, the News Just Got Even Better

For Chronic Leukemia Patients, the News Just Got Even Better

Thursday, November 29, 2018

woman scientist looking at a chart next to a microscope

Several chronic lymphocytic leukemia (CLL) patients at the Wilmot Cancer Institute took part in two groundbreaking, nationwide phase 3 studies that are changing the way doctors treat the disease. The positive results are being reported this weekend at the 2018 American Society of Hematology (ASH) annual meeting — and will immediately impact CLL patients in the Rochester region and across the U.S., said Paul Barr, M.D., director of Wilmot’s Clinical Trials Office.

“We plan to share these results with the many patients who participated in these studies,” Barr said. “Not only were they able to receive the safest, most effective cutting-edge therapy, but they helped to define future treatment options for patients coming after them.”

Already the median overall survival for patients with CLL has tripled during the last 30 years, thanks to better understanding of the disease biology and new drug development, and the latest clinical trials will result in further improvements, Barr said.

The new studies compared the current standard treatments for front-line chemotherapy with regimens using a combination of ibrutinib, a drug that targets BTK, a critical protein in CLL, and rituximab, a type of immunotherapy. Ibrutinib is taken as a pill and is often less toxic than chemotherapy.  One study was designed for patients younger than 70 years old, while the other was designed for older patients.

The clinical research represents the first time ibrutinib/rituximab has been directly compared to the most aggressive and promising therapies available today. Both studies showed that ibrutinib provided a longer time of remission compared to chemotherapy. The same drug has been extensively tested in certain patients with relapsed CLL, and was also shown to be safe and effective.

For more detailed scientific data, please visit:

https://ash.confex.com/ash/2018/webprogram/Paper116653.html

https://ash.confex.com/ash/2018/webprogram/Paper120779.html

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Leslie Orr

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