Treatment Advances for Lymphoma have Reduced Deaths by 70%
Wednesday, October 19, 2005
Richard I. Fisher, M.D.
New state-of-the-art treatment advances for patients with follicular lymphoma, previously considered an incurable cancer, have reduced deaths in the first four years by 70 percent. A newly published study recommends that doctors carefully choose their patients’ initial therapies because there may be significant differences in overall survival rates, according to researchers at the University of Rochester Medical Center’s James P. Wilmot Cancer Center.
Scientists compared outcomes for 960 patients treated with three different regimens and survival rates vary from 91 percent for the newest treatments using monoclonal antibodies, to 69 percent for standard therapy.
“This is real evidence that the clinical advances we’ve made over the last 30 years are prolonging lives,” said Richard I. Fisher, M.D., director of the Wilmot Cancer Center and lead author on a paper published online by the Journal of Clinical Oncology. “Some of the new therapies that include monoclonal antibodies have revolutionized treatment of this disease.”
Wilmot Study: Treatment Advances for Lymphoma have Reduced Deaths by 70%
Follicular lymphoma, a slow growing cancer of the lymphatic system, affects about 30,000 older adults each year in the U.S. Median survival has been seven to 10 years but until this study, there was no evidence of any recent improvements.
Fisher and colleagues from the Southwest Oncology Group, Fred Hutchinson Cancer Research Center in Seattle and University of Arizona Cancer Center assessed three common therapies that have been used over the last two decades.
In the head-to-head comparison, they found that standard therapy – a four-drug combination called CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) - along with new monoclonal antibodies – rituximab or iodine-131 tositumomab - offers the best survival rate during the first four years. They studied 179 patients who were treated with this regimen during the late 1990s and the survival rate was 91 percent.
The second arm included 425 patients treated during the 1980s with ProMACE-MOPP, an eight-drug, combo-chemotherapy regimen, and 79 percent survived at the four-year point. The third group of 356 patients received CHOP plus immunostimulant therapies during the 1970s and the four-year survival rate was 69 percent.
“This data gives doctors and patients real evidence that initial treatment decisions has significant impact on the length of survival,” Fisher said.
Fisher has studied CHOP therapy and other combinations with the Southwest Oncology Group, one of the largest research cooperative groups, for the last three decades. He led studies that demonstrated its effectiveness as a treatment for aggressive lymphomas.
The Wilmot Cancer Center has established one of the Northeast’s largest hematologic malignancies teams, specializing in the multidisciplinary treatment of lymphomas and leukemias. Wilmot hematologists are currently comparing the two most effective therapies – CHOP plus rituximab and CHOP plus iodine-131 tositumomab.