Arthur Moss, M.D.

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Through a career that spans nearly six decades, Arthur Moss has saved countless lives and changed the treatment of heart disease worldwide through his research.

Moss has published more than 500 scientific papers focused on cardiac arrhythmias, electrical malfunctions that can throw the heartbeat out of rhythm and sometimes stop the heart altogether. Moss spearheaded the research that led to the widespread use of the implantable cardioverter defibrillator (ICD), a device that shocks the heart back into proper rhythm when a dangerous rhythm is detected. Moss led the study in 2002 that changed medical guidelines nationwide, making tens of thousands of heart attack survivors eligible for ICD therapy each year – a timely contribution as doctors’ increasing success treating heart attack survivors translates to more and more patients who live with heart disease on a chronic basis.

Moss is also an expert on the genetics of heart disease and was one of the first scientists to attempt to unravel the genetic underpinnings of a specific heart condition. Since the 1960s Moss has studied Long QT syndrome, which makes the heart susceptible to fatal arrhythmias. In 1979, Moss helped launch the International LQTS Registry, a database of families with the LQTS trait and one of the first gene registries for any disease in the world. By following generations of patients with this disorder, gene hunters have used the registry to track down more than 500 genetic mutations involving 10 genes that cause various versions of the syndrome. As a result, Moss and colleagues have been able to identify patients at risk for the life-threatening heart rhythm disorder and to develop effective treatments, resulting in an 80 percent reduction in life-threatening events for patients with Long QT syndrome.

Moss is a fellow of the American College of Physicians and the American College of Cardiology.

Topics:

  • Sudden cardiac death
  • Electrocardiology
  • ICDs
  • CRT-Ds
  • Long QT syndrome
  • The genetics of heart disease

Professor of Cardiology in the Department of Medicine

Director, Heart Research Follow-Up Program

University of Rochester Medical Center

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