Jeffrey Alexis, M.D.

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Jeffrey Alexis’ dual clinical and research focus on heart failure and transplantation affords him a unique perspective on a condition that affects millions of Americans. Alexis specializes in the treatment of patients with severe, end-stage heart failure, working to manage the disease with medications and determine if patients are good candidates for a transplant or surgery to implant a ventricular assist device (VAD). With advances in transplants and the increasing use of VADs as destination or final therapy, Alexis cares for a growing number of post-transplant/implant heart failure patients who are living longer than ever before and often struggle with new problems, such as vascular disease.

Alexis’ research stems from his clinical work and focuses on bleeding in individuals with VADs – a large problem that affects approximately 25 percent of patients. While some bleeding events may be relatively minor, like a nose bleed, other events, such as gastrointestinal bleeding, may be life threatening. Alexis is studying a protein called von Willebrand factor (vWF) – which ordinarily works to prevent bleeding, but is abnormal in patients with VADs – in order to identify risk factors for bleeding in this group.

Alexis also treats and conducts research on peripartum cardiomyopathy, a rare disorder in which the heart weakens in the final months of pregnancy or shortly after delivery. Unfortunately, doctors understand very little about the condition. Alexis is investigating possible causes and how to improve the quality of life for women with the disorder.

Alexis is a fellow of the American College of Cardiology, and a member of the American Heart Association, the Association of Black Cardiologists, and the International Society for Heart and Lung Transplantation.


  • Heart failure
  • Heart transplant
  • Ventricular assist devices (VADs)
  • Vascular disease
  • Coronary artery disease
  • Peripartum cardiomyopathy

Associate Professor of Cardiology in the Department of Medicine

University of Rochester Medical Center

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