URMC / New York Influenza Center of Excellence / Publications / 2019 Publications 2019 Publications 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | Archived 2019, December Krammer F, Li L, Wilson PC Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination. PMID: 31951584 Nayak J, Hoy G, Gordon A Influenza in Children. PMID: 31871228 Nogales A, Aydillo T, Ávila-Pérez G, Escalera A, Chiem K, Cadagan R, DeDiego ML, Li F, García-Sastre A, Martínez-Sobrido L Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo. PMID: 31921042 Shannon I, White CL, Nayak JL Understanding Immunity in Children Vaccinated With Live Attenuated Influenza Vaccine. PMID: 31848606 Wan H, Gao J, Yang H, Yang S, Harvey R, Chen YQ, Zheng NY, Chang J, Carney PJ, Li X, Plant E, Jiang L, Couzens L, Wang C, Strohmeier S, Wu WW, Shen RF, Krammer F, Cipollo JF, Wilson PC, Stevens J, Wan XF, Eichelberger MC, Ye Z The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. PMID: 31406333 Topham DJ, DeDiego ML, Nogales A, Sangster MY, Sant A Immunity to Influenza Infection in Humans. PMID: 31871226 Zost SJ, Lee J, Gumina ME, Parkhouse K, Henry C, Wu NC, Lee CD, Wilson IA, Wilson PC, Bloom JD, Hensley SE Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans. PMID: 31875553 2019, November Knowlden ZAG, Richards KA, Moritzky SA, Sant AJ Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection. PMID: 31694141 Harding AT, Haas GD, Chambers BS, Heaton NS Influenza viruses that require 10 genomic segments as antiviral therapeutics. PMID: 31730644 2019, October Rodriguez L, Blanco-Lobo P, Reilly EC, Maehigashi T, Nogales A, Smith A, Topham DJ, Dewhurst S, Kim B, Martínez-Sobrido L Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines. PMID: 31658679 Gouma S, Zost SJ, Parkhouse K, Branche A, Topham DJ, Cobey S, Hensley SE Comparison of human H3N2 antibody responses elicited by egg-based, cell-based, and recombinant protein-based influenza vaccines during the 2017-2018 season. PMID: 31598646 2019, September Sangster MY, Nguyen PQT, Topham DJ Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection. PMID: 31569328 Zhang H, Miller BL Immunosensor-based label-free and multiplex detection of influenza viruses: State of the art. PMID: 31272058 Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PMID: 31557273 Wasik BR, de Wit E, Munster V, Lloyd-Smith JO, Martinez-Sobrido L, Parrish CR Onward transmission of viruses: how do viruses emerge to cause epidemics after spillover? PMID: 31401954 DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza. PMID: 31399519 Wasik BR, Voorhees IEH, Barnard KN, Alford-Lawrence BK, Weichert WS, Hood G, Nogales A, Martínez-Sobrido L, Holmes EC, Parrish CR Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation. PMID: 31511393 2019, August Dumm RE, Heaton NS The Development and Use of Reporter Influenza B Viruses. PMID: 31404985 DeDiego ML, Nogales A, Martinez-Sobrido L, Topham DJ Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. PMID: 31455651 Lee JM, Eguia R, Zost SJ, Choudhary S, Wilson PC, Bedford T, Stevens-Ayers T, Boeckh M, Hurt AC, Lakdawala SS, Hensley SE, Bloom JD Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin. PMID: 31452511 Wang H, Dou D, Östbye H, Revol R, Daniels R Structural restrictions for influenza neuraminidase activity promote adaptation and diversification. PMID: 31451775 Richards KA, Shannon I, Treanor JJ, Yang H, Nayak JL, Sant AJ Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects. PMID: 31504534 DeDiego ML, Martinez-Sobrido L, Topham DJ Novel functions of the interferon-induced protein 44-like (IFI44L) as a feedback regulator of host antiviral responses. PMID: 31434731 Henry C, Palm AE, Utset HA, Huang M, Ho IY, Zheng NY, Fitzgerald T, Neu KE, Chen YQ, Krammer F, Treanor JJ, Sant AJ, Topham DJ, Wilson PC Monoclonal antibody responses after recombinant HA vaccine versus subunit inactivated influenza virus vaccine: a comparative study. PMID: 31434733 Fiege JK, Stone IA, Fay EJ, Markman MW, Wijeyesinghe S, Macchietto MG, Shen S, Masopust D, Langlois RA The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection. PMID: 31235552 Chiem K, Rangel-Moreno J, Nogales A, Martinez-Sobrido L A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection. PMID: 31475986 Gouma S, Weirick M, Hensley SE Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine. PMID: 31400756 Brewer MG, Anderson EA, Pandya RP, De Benedetto A, Yoshida T, Hilimire TA, Martinez-Sobrido L, Beck LA, Miller BL Peptides Derived from the Tight Junction Protein, Claudin-1, Disrupt Skin Barrier and Promote Responsiveness to an Epicutaneous Vaccine. PMID: 31381894 2019, July Khurana S, Hahn M, Coyle EM, King LR, Lin TL, Treanor J, Sant A, Golding H Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans. PMID: 31350391 Palm AE, Henry C Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination. PMID: 31417562 Simon LM, Morandi E, Luganini A, Gribaudo G, Martinez-Sobrido L, Turner DH, Oliviero S, Incarnato D In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs. PMID: 31053845 Rattan A, Richards KA, Knowlden ZAG, Sant AJ Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection. PMID: 31341045 Karyolaimos A, Ampah-Korsah H, Hillenaar T, Mestre Borras A, Dolata KM, Sievers S, Riedel K, Daniels R, de Gier JW Enhancing Recombinant Protein Yields in the E. coli Periplasm by Combining Signal Peptide and Production Rate Screening. PMID: 31396164 2019, June Sagong HY, Bauman JD, Nogales A, Martínez-Sobrido L, Arnold E, LaVoie EJ Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease. PMID: 30983160 Moreno-Pescador G, Florentsen CD, Østbye H, Sønder SL, Boye TL, Veje EL, Sonne AK, Semsey S, Nylandsted J, Daniels R, Bendix PM Curvature- and Phase-Induced Protein Sorting Quantified in Transfected Cell-Derived Giant Vesicles. PMID: 31199124 2019, May Li D, Wang J, Garigen J, Treanor JJ, Zand MS Continuous Readout versus Titer-Based Assays of Influenza Vaccine Trials: Sensitivity, Specificity, and False Discovery Rates. PMID: 31205481 Nelson SA, Sant AJ Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus. PMID: 31134060 2019, April Sant AJ The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells. PMID: 30715376 Varga SM, Sant AJ Forward to: Orchestration of an Immune Response to Respiratory Pathogens. PMID: 31024541 Christensen SR, Toulmin SA, Griesman T, Lamerato LE, Petrie JG, Martin ET, Monto AS, Hensley SE Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk. PMID: 30700610 Ranjeva S, Subramanian R, Fang VJ, Leung GM, Ip DKM, Perera RAPM, Peiris JSM, Cowling BJ, Cobey S Age-specific differences in the dynamics of protective immunity to influenza. PMID: 30971703 Zhang Y, Bandyopadhyay G, Topham DJ, Falsey AR, Qiu X Highly efficient hypothesis testing methods for regression-type tests with correlated observations and heterogeneous variance structure. PMID: 30987598 2019, March Nogales A, Ávila-Pérez G, Rangel-Moreno J, Chiem K, DeDiego ML, Martínez-Sobrido L A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections. PMID: 30867298 Piepenbrink MS, Nogales A, Basu M, Fucile CF, Liesveld JL, Keefer MC, Rosenberg AF, Martinez-Sobrido L, Kobie JJ Broad and Protective Influenza B Virus Neuraminidase Antibodies in Humans after Vaccination and their Clonal Persistence as Plasma Cells. PMID: 30862743 Henry C, Zheng NY, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE, Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. PMID: 30795982 Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain. PMID: 29511250 2019, February Blanco-Lobo P, Nogales A, Rodríguez L, Martínez-Sobrido L Novel Approaches for The Development of Live Attenuated Influenza Vaccines. PMID: 30813325 Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus. PMID: 30728266 Chen YQ, Lan LY, Huang M, Henry C, Wilson PC Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance. PMID: 30518651 2019, January Shannon I, White CL, Murphy A, Qiu X, Treanor JJ, Nayak JL Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults. PMID: 30692574 Neu KE, Guthmiller JJ, Huang M, La J, Vieira MC, Kim K, Zheng NY, Cortese M, Tepora ME, Hamel NJ, Rojas KT, Henry C, Shaw D, Dulberger CL, Pulendran B, Cobey S, Khan AA, Wilson PC Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination. PMID: 30457979 Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. PMID: 30539468