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2013 Publications

2013 Dec
Bialas KM, Bussey KA, Stone RL, Takimoto T.
Specific nucleoprotein residues affect influenza virus morphology.
J Virol. PMID:24335312

2013 Nov
Tse LV, Hamilton AM, Friling T, Whittaker GR.
A Novel Activation Mechanism of Avian Influenza Virus H9N2 by Furin.
J Virol. PMID:24257604

2013 Oct
Alam S, Knowlden ZA, Sangster MY, Sant AJ.
CD4 T cell help is limiting and selective during the primary B cell response to influenza infection.
J Virol. PMID:24155379

2013, July
Li Y, Myers JL, Bostick DL, Sullivan CB, Madara J, Linderman SL, Liu Q, Carter DM, Wrammert J, Esposito S, Principi N, Plotkin JB, Ross TM, Ahmed R, Wilson PC, Hensley SE
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.
PMID: 23857983

2013 Jun
Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K.
B Cell Response and Hemagglutinin Stalk-Reactive Antibody Production in Different Age Cohorts following 2009 H1N1 Influenza Virus Vaccination.
Clin Vaccine Immunol. PMCID:PMC3675965

2013 Jun
Nayak JL, Alam S, Sant AJ.
Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to HA.
J Immunol. PMID:23794632

2013 Jun 
Yang H, Topham DJ, Holden-Wiltse J, Wu H.
Statistical Estimation & Inference of Cell Counts form ELISPOT Limiting Dilution Assays.
J Biopharm Stat. PMCID: PMC3803109

2013 Jun
Tung J, Sant AJ.
Orchestration of CD4 T cell epitope preferences after multi-peptide immunization.
J Immunol. PMID:23772029

2013 May
Baker SF, Guo H, Albrecht RA, Garcia-Sastre A, Topham DJ, Martinez-Sobrido L.
Protection against lethal influenza with a viral mimic.
J Virol. PMCID: PMC3719819

2013 Apr
Hamilton, BS, Whittaker GR.
Cleavage activation of the human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
J Biol Chem. PMID:23612974

2013 Feb
Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR.
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin independent of the viral neuraminidase.
J Virol. PMCID: PMC3624321

2013 Jan
Desmet EA, Bussey KA, Stone R, Takimoto T.
Identification of the N-terminal domain of influenza PA responsible for the suppression of host protein synthesis.
J Virol. 87(6):3108-18. PMCID: PMC3592176

2012 Publications

2012 Nov
Bialas KM, Desmet EA, Takimoto T.
Specific Residues in the 2009 H1N1 Swine-Origin Influenza Matrix Protein Influence Virion Morphology and Efficiency of Viral Spread in vitro.
PLoS One. 7(11):e50595. PMCID: PMC3507794

2012 Nov 
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ.
CD4 T-cell expansion predicts neutralizing antibody responses to monovalent inactivated pandemic H1N1 influenza vaccine.
J Infect Dis. 207(2):297-305. PMCID: PMC3532833

2012 Oct
Richards KA, Chaves FA, Alam S, Sant AJ.
Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins.
Vaccine. 31(1):218-25. PMCID: PMC3690927

2012 Oct
Leddon SA, Sant AJ.
The Peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization.
PLoS One. 7(10):46952. PMCID: PMC3471970

2012 Oct
Hamilton BS, Sun X, Chung C, Whittaker GR.
Acquisition of a novel eleven amino acid insertion directly N-terminal to a tetrabasic cleavage site confers intracellular cleavage of an H7N7 influenza virus hemagglutinin.
Virology. pii: S0042-6822(12)--445-X. PMCID: PMC3626165

2012 Oct
Perez JT, Zlatev I, Aggarwal S, Subramanian S, Sachidanandam R, Kim B, Manoharan M, Tenoever BR.
A Small RNA Enhancer of Viral Polymerase Activity.
J Virol. 86(24):13475-85. PMCID: PMC3503082

2012 Oct
Costello DA, Lee DW, Drewes J, Vasquez KA, Kisler K, Wiesner U, Pollack L, Whittaker GR, Daniel S.
Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.
Anal Chem. 84(20):8480-9. PMCID: PMC3489278

2012 Aug
Nayak JL, Sant AJ.
Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host.
Immunology. 136(4):425-36. PMCID: PMC3401981

2012 Jul
Sant AJ, McMichael A.
Revealing the role of CD4(+) T cells in viral immunity.
J Exp Med. 209(8):1391-5. PMCID: PMC3420330

2012 Jul
Noble E, Cox A, Deval J, Kim B.
Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.
Virology. 433(1):27-34. PMCID: PMC3647620

2012 Jul
Hamilton BS, Whittaker GR, Daniel S.
Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion.
Viruses. 4(7):1144-68. PMCID: PMC3407899

2012 Jul
Hamilton BS, Gludish DW, Whittaker GR.
Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities.
J Virol. 86(19):10579-86. PMCID: PMC3457293

2012 May
Santiago FW, Lambert Emo K, Fitzgerald T, Treanor JJ, Topham DJ.
Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems.
Vaccine. 30(31):4606-16. PMCID: PMC3379008

2012 May
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ.
The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection.
J Immunol. 188(9):4235-48. PMCID: PMC3331894

2012 Apr
Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR.
Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination.
Vaccine. 30(31):4581-4. PMCID: PMC3858959

2012 Apr
MacDonald LA, Aggarwal S, Bussey KA, Desmet EA, Kim B, Takimoto T.
Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies.
Virology. 426(1):51-9. PMCID: PMC3285403

2012 Mar
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ.
Host difference in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.
PLoS One. 7(3):e34377. PMCID: PMC3311631

2012 Mar
Noronha JM, Liu M, Squires RB, Pickett BE, Hale BG, Air GM, Galloway SE, Takimoto T, Schmolke M, Hunt V, Klem E, García-Sastre A, McGee M, Scheuermann RH.
Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.
J Virol. 86(10):5857-66. PMCID: PMC3347290

2011 Publications

2011 Oct
Aggerwal S, Dewhurst S, Takimoto T, Kim B.
Biochemical impact of the host adaptation associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.
J Biol Chem. 286(40):34504-13. PMCID: PMC3186381

2011 Oct
Alam S, Sant AJ.
Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus.
J Virol. 85(24):13310-21. PMCID: PMC3233140

2011 Sep
Santiago FW, Fitzgerald T, Treanor JJ, Topham DJ.
Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus.
Vaccine. 29(48):8888-97. PMCID: PMC3202679

2011 Jun
Bradel-Tretheway BG, Mattiacio JL, Krasnoselsky A, Stevenson C, Dewhurst S, Katze MG.
Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors.
J Virol. 85(17)8569-81. PMCID: PMC3165779

2011 May
Chapman TJ, Lambert K, Topham DJ.
Rapid Reactivation of Extralymphoid CD4 T cells During Secondary Infection.
PLoS One. 6(5):e20493. PMCID: PMC3103554

2011 May
Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T.
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian virus polymerase activity in mammalian cells.
J Virol. 85(14):7020-8. PMCID: PMC3126589

2011 May
Noble E, Mathews DH, Chen JL, Turner DH, Takimoto T, Kim B.
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.
J Biol Chem. 286(26):22965-70. PMCID: PMC3123064

2011 Mar 
Richards KA, Chaves FA, Sant AJ.
The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity.
Immunology.133(2):246-56. PMCID: PMC3088986

2011 Mar
Nayak JL, Sant AJ.
T cell Immunology for the clinician.
Pediatric Infectious Diseases. 30:248-50. PMID:21317604

2011 Jan
Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ.
CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.
Vaccine. 29(11):2159-68. PMCID: PMC3061835

2010 Publications

2010 Oct
Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ.
T cell mediated protection against lethal 2009 pandemic H1N1 influenza infection in a mouse model.
J Virol. 85(1):448-55. PMCID: PMC3014175

2010 Oct
Richards KA., Topham DT, Chaves FA, Sant AJ
Cutting edge: CD4 T cells generated from encounter with the seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus.
J. Immunol. 185(9):4998-5002. PMID:20889549

2010 Jun
Sun X, Tse LV, Ferguson AD, Whittaker GR.
Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.
J Virol. 84(17):8683-90. PMCID: PMC2919019

2010 Apr
Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B.
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
PLoS One. 5(4):e10372. PMCID: PMC2861597

2010 Apr
Nayak JL, Richards KA, Chaves FA, Sant AJ.
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins.
Viral Immunol. 23(2):169-80. PMCID: PMC2883523

2010 Mar
Chapman TJ, Topham DJ.
Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
J Immunol. 184(7):3841-9. PMCID: PMC2843798

2010 Feb 
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB.
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.
Virology. 400(2):224-32. PMCID: PMC2844475

2010 Feb
Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T.
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol. 84(9): 4395–406. PMCID: PMC2863787

2009 Publications

2009 Dec
Nayak J, Treanor J.
Antiviral treatment and prophylaxis of influenza virus in children.
Pediatric Annals. 38(12):667-74. PMID:20000234

2009 Nov 
Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ.
B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant.
Vaccine. 28(4):907-15. PMCID: PMC2814950

2009 May
Weaver JM, Chaves FA, Sant AJ.
Abortive activation of CD4 T cell responses during competitive priming in vivo.
Proc Natl Acad Sci U S A. 106(21):8647-52. PMCID: PMC2689016

2009 Apr 
Richards KA, Chaves FA, Sant AJ.
Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus.
J Virol. 83(13):6566-77. PMCID: PMC2698557

2009 Feb
Weaver J, Sant AJ.
Understanding the focused CD4 T cell response to antigen and pathogenic organisms.
Immunol Res. 45:123-43. PMID:19198764

2008 Publications

2008 Dec
Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S.
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.
J Gen Virol. 89(Pt 12):2923-32. PMCID: PMC3067610

2008 Sep
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ.
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.
J Immunol. 181(5):3039-48. PMCID: PMC2814425

2008, May
Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, Zheng NY, Mays I, Garman L, Helms C, James J, Air GM, Capra JD, Ahmed R, Wilson PC.
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.
Nature. 2008 May 29;453(7195):667-71. PMID: 18449194