URMC / New York Influenza Center of Excellence / Publications / 2017 Publications 2017 Publications 2020 | 2019 | 2018 | 2017 | 2016 | Archived 2017, Dec Koday MT, Leonard JA, Munson P, Forero A, Koday M, Bratt DL, Fuller JT, Murnane R, Qin S, Reinhart TA, Duus K, Messaoudi I, Hartman AL, Stefano-Cole K, Morrison J, Katze MG, Fuller DH Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates. PMID: 29267331 2017, Nov Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain. PMID: 29097696 Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins. PMID: 29145498 Zost SJ, Parkhouse K, Gumina ME, Kim K, Diaz Perez S, Wilson PC, Treanor JJ, Sant AJ, Cobey S, Hensley SE Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. PMID: 29109276 2017, Oct He W, Chen CJ, Mullarkey CE, Hamilton JR, Wong CK, Leon PE, Uccellini MB, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson PC, Miller MS, Krammer F, Palese P, Tan GS Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. PMID: 29018261 Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A Natural polyreactive IgA antibodies coat the intestinal microbiota. PMID: 28971969 2017, Sept Forero A, Fenstermacher K, Wohlgemuth N, Nishida A, Carter V, Smith EA, Peng X, Hayes M, Francis D, Treanor J, Morrison J, Klein SL, Lane A, Katze MG, Pekosz A Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells. PMID: 28967519 DiPiazza A, Nogales A, Poulton N, Wilson PC, Martínez-Sobrido L, Sant AJ Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo. PMID: 28883436 Langevin S, Pichon M, Smith E, Morrison J, Bent Z, Green R, Baker K, Solberg O, Gillet Y, Javouhey E, Lina B, Katze MG, Josset L Early nasopharyngeal microbial signature associated with severe influenza in children: a retrospective pilot study. PMID: 28884664 Rodriguez L, Nogales A, Martínez-Sobrido L Influenza A Virus Studies in a Mouse Model of Infection. PMID: 28930978 2017, Aug Domm W, Yee M, Misra RS, Gelein R, Nogales A, Martinez Sobrido L, O'Reilly MA Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus. PMID: 28798254 Rodriguez L, Nogales A, Murcia PR, Parrish CR, Martínez-Sobrido L A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses. PMID: 28709557 Nogales A, Chauché C, DeDiego ML, Topham DJ, Parrish CR, Murcia PR, Martínez-Sobrido L Amino acid substitution K186E in the canine influenza virus H3N8 NS1 protein restores its ability to inhibit host gene expression. PMID: 28835506 Nogales A, Rodriguez L, DeDiego ML, Topham DJ, Martínez-Sobrido L Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus. PMID: 28637750 Leon PE, Wohlbold TJ, He W, Bailey MJ, Henry CJ, Wilson PC, Krammer F, Tan GS Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies. PMID: 28872136 2017, June Stamper CT, Wilson PC What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection? PMID: 28630076 Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML Functional evolution of influenza NS1 protein in currently circulating human 2009 pandemic H1N1viruses. PMID: 28637754 2017, May Alam S, Chan C, Qiu X, Shannon I, White CL, Sant AJ, Nayak JL Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection. PMID: 28493882 Perez DR, Angel M, Gonzalez-Reiche AS, Santos J, Obadan A, Martinez-Sobrido L Plasmid-Based Reverse Genetics of Influenza A Virus. PMID: 28508225 Yang H, Holden-Wiltse J, Topham DJ, Treanor J Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model. PMID: 28541821 2017, Apr Treanor J Flu Vaccine-Too Much of a Good Thing? PMID: 28180278 Rodriguez L, Nogales A, Reilly EC, Topham DJ, Murcia PR, Parrish CR, Martinez Sobrido L A live-attenuated influenza vaccine for H3N2 canine influenza virus. PMID: 28167384 Lee DW, Whittaker GR Use of AAScatterPlot tool for monitoring the evolution of hemagglutinin cleavage site in H9 avianviruses. PMID: 28383669 2017, Mar Jegaskanda S, Co MDT, Cruz J, Subbarao K, Ennis FA, Terajima M Induction of H7N9-Cross-Reactive Antibody-Dependent Cellular Cytotoxicity Antibodies by Human Seasonal Influenza A Viruses that are Directed Toward the Nucleoprotein. PMID: 28011910 Straus MR, Whittaker GR A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site. PMID: 28358853 2017, Feb Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses. PMID: 28003482 Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JP, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection. PMID: 28215994 Cobey S, Hensley SE Immune history and influenza virus susceptibility. PMID: 28088686 2017, Jan Nogales A, Huang K, Chauché C, DeDiego ML, Murcia PR, Parrish CR, Martínez-Sobrido L Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. PMID: 27750071 Nogales A, Rodriguez L, Chauché C, Huang K, Reilly EC, Topham DJ, Murcia PR, Parrish CR, Martínez-Sobrido L Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine. PMID: 27928017 Santhakumar D, Rubbenstroth D, Martinez-Sobrido L, Munir M Avian Interferons and Their Antiviral Effectors. PMID: 28197148 Nogales A, Rodriguez L, Chauché C, Huang K, Reilly EC, Topham DJ, Murcia PR, Parrish CR, Martínez-Sobrido L Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine. PMID: 27928017 DiPiazza A, Richards K, Poulton N, Sant AJ Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity. PMID: 28100497 Lau D, Lan LY, Andrews SF, Henry C, Rojas KT, Neu KE, Huang M, Huang Y, DeKosky B, Palm AE, Ippolito GC, Georgiou G, Wilson PC Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation. PMID: 28783670