Two major roadblocks can be identified that have hindered efforts to be better prepared for the next pandemic of influenza. First, current vaccines do not provide durable and broadly cross protective immunity, precluding effective stockpiling and requiring yearly vaccination. Second, although the role of avian influenza viruses in the generation of new pandemics has been clearly described, the exact features that control species specificity are poorly understood, significantly hampering our ability to predict pandemics. The New York Influenza Center of Excellence (NYICE) is a collaborative, interdisciplinary approach involving investigators in the fields of immunology, virology, biochemistry, medicine, pediatrics, statistics and bioinformatics that will address directly the issues of cross-protective immunity and virus adaptation to the mammalian host. Our goal is to provide a truly transforming approach to influenza research.
Environment for Influenza Research
Research on the immunology and pathogenesis of influenza at NYICE will take place in a rich environment of highly collaborative center grants that are devoted in large measure to influenza vaccine development, immune response, pathogenesis, and epidemiology. Importantly, each of these programs has a clear focus on influenza in humans, and each will provide synergistic contributions to the research program we will carry forward in NYICE. In addition to influenza research, the medical center also excels in other respiratory viruses research.
Concept Proposal Applications
The New York Influenza Center of Excellence at the University of Rochester Medical Center is seeking concept proposals for innovation projects related to influenza virus infection, pathogenesis, and host responses.
Preliminary proposals should be three (3) pages or less, indicating the estimated timeline for deliverables and budget for the entire project. Detailed budgets are not needed, but must exclude tenure-track faculty salaries. Project budgets should include total costs per project. Requests for budgets in excess of the $100,000 - $200,00 range will be considered, but costs and deliverables are part of the evaluation criteria. Matching funds by departments and centers are encouraged.
Applications are reviewed on an ongoing basis. Download below application and submit electronically in PDF format to Ms. Donna Neu at Donna_Neu@URMC.Rochester.edu.
Concept Proposal Application: NYICE-concept-template
Budget Form: 398-calculating-budget-v1
View current clinical studies at the University of Rochester Medical Center
The CEIRS Reagents webpage is a searchable and filterable catalog of over 5,000 unique, influenza-specific reagents developed by CEIRS researchers that are available to the broader scientific community. Search, sort, and filter reagents of interest by strain, vector, segment, mutations, availability in BEI, published status, and request directly from the CEIRS Reagents webpage.