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Influenza Surveillance

Acute Influenza in Adults, Children, and the Elderly

The Acute Influenza in Adults, Children, and the Elderly study will be conducted as a prospective surveillance study according to the schema outlined in the figure below (click to view larger):

The objectives of this protocol are:

  • Acquisition of samples for the analysis of adaptive immune responses in the peripheral blood of individuals infected with influenza virus.
  • Identification of cross-reactive T and B cell responses to the emerging influenza viruses
  • Characterization of protective and/or potentially pathogenic T cell differentiation associated with seasonal or novel influenza virus infection.
  • Characterization of the levels and duration of viral shedding in infected individuals and correlation of viral shedding with the severity of influenza symptoms.
  • Determination of the frequency of asymptomatic infection of household contacts
  • Characterization of phenotypic and genotypic changes in viruses during the course of the pandemic, determination whether evolution and adaptation are taking place.
  • Development of kinetic data related to viral replication and humoral and cellular immune responses to infection that could be used in computer models of the human immune response to influenza