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The Infant Development and the Environment Study


TIDES: The Infant Development and Environment Study

Participation in The Infant Development and the Environment Study (TIDES) began when pregnant mothers were in their first trimester of pregnancy and ended shortly after birth for girl babies and at 1-year old for boy babies.  During the first 5 years of TIDES, we enrolled almost 800 moms and their babies across four research study sites (Rochester, NY, Seattle, WA, Minneapolis, MN, and San Francisco, CA).

Our study suggests that prenatal exposure to common chemicals in our diet and homes – phthalates, which make plastics soft and flexible – may affect reproductive tract development during pregnancy of boys, but not that of girls, and these results are affected by the amount of stress the moms reported during pregnancy.

TIDES Follow-Up Study – What’s Happening Now

Because of the success of the initial TIDES and the importance of these and other findings related to phthalate exposures, the National Institutes of Health has funded the next phase of TIDES, which we are calling TIDES II. This phase will allow us to learn more about TIDES moms and their TIDES children as they grow up. TIDES II will continue to be based at the Icahn School of Medicine at Mount Sinai and will involve up to 700 families in Rochester, NY; Minneapolis, MN; Seattle, WA; and San Francisco, CA.

TIDES II gives us the opportunity to extend our knowledge beyond pregnancy and learn about the potential effects of prenatal and postnatal phthalates on the development of young children. Your participation will help us understand how the early environment can affect a child’s growth, well-being, and behavior.

We hope our TIDES families will continue to be part of this important and innovative study!

What Does Participation in TIDES II Involve?

Participation in TIDES II will consist of:

  • An online questionnaire to be completed prior to the clinic visit
  • A few additional surveys at the visit
  • The following measurements on your TIDES child: height, weight, skinfold thickness, blood pressure, urine and saliva collection, and a measure of pulse wave velocity. We will also perform a neurocognitive exam on both you and your child (this entails looking at pictures, answering questions, and working with blocks).

Participant families (mother and child) will receive $75 in gift cards for the first visit and $125 in gift cards for the second visit, totaling $200 in gift cards for the completion of all study requirements.

Next Steps

If you agreed to be contacted for further participation when TIDES was ending, Andrea Hart, the TIDES II study coordinator will contact you via email or phone to determine your interest in participating. Should you agree to participate, we will schedule you and your child according your availability. If childcare or late visit times are needed, please ask. We are happy to accommodate your schedule. We very much look forward to being in contact with you again!

Study Visit Locations

Lattimore Road Women's CenterMother and child visits for TIDES II will take place at the Ob/Gyn Ultrasound service at 125 Lattimore Rd.  Our Lattimore facility is easy to get to, on the bus line, and parking is free.  Enter building through the West Entrance, turn right and walk through the door to the Women’s Health Practice/Ultrasound Suite.  Give your name to the Ultrasound receptionist, and our team will meet you in the waiting area to the right.


Study Team

Emily BarrettEmily S. Barrett, PhD
Adjunct Associate Professor of Obstetrics and Gynecology and Public Health Sciences at the University of Rochester Medical Center.

Dr. Barrett is the TIDES II center director for the Rochester, NY study site.  Dr. Barrett’s research focuses on how environmental exposures across the life course affect reproductive function. Dr. Barrett first became interested in this topic during her doctoral work in Biological Anthropology at Harvard University, where her dissertation focused on understand variation in women’s ovarian function. She has since expanded her work to examine how endocrine-disrupting exposures, including environmental chemicals and stress, may impact reproductive development. To that end, she has worked on several large pregnancy cohort studies including the National Children’s Study and TIDES. She is also principal investigator of the Study of Early Life and Fertility (SELF) and Understanding Pregnancy Signals and Infant Development (UPSIDE).


Andrea Hart
Study Coordinator