Second-year Pathology graduate student Madison Doolittle won second place in the School of Medicine and Dentistry’s graduate student poster competition on May 17.
The annual event, hosted by the Graduate Student Society, includes entries from graduate students across disciplines as an opportunity to showcase their research in their respective fields.
Madison was the lead author the abstract titled, “Investigating the Role of Zbtb40 in the Genetic Regulation of Osteoporosis” in which he and fellow researchers examined the genetic determinants of bone mineral density used to diagnose osteoporosis.
He was awarded a $300 travel scholarship.
Karen de Mesy Bentley (formerly Jensen), M.S., director of the Electron Microscopy Shared Resource Laboratory and faculty associate in the Department of Pathology and Laboratory Medicine, has discovered something new about the behavior of Staphylococcus aureus bacteria and why it may resist antibiotic treatment and recur in patients who have had a hip or joint implant.
Bentley is the lead author in an NIH funded study published in the Journal of Bone and Mineral Research (May 2017) where she utilized transmission electron microscopy (TEM) to examine the bones of mice with implant associated S. aureus chronic osteomyelitis.
While examining sections of bone under TEM high magnification, Bentley discovered that some bacteria were able to change shape and squeeze into submicron spaces which are called canaliculi. Her study describes round bacteria becoming rod-shaped to accommodate the submicron diameter space of canaliculi. The bacteria are then protected from treatment with traditional antibiotics delivered via blood vessels.
“When I saw this, I was shocked,” said Bentley. “Staph has never been described as being able to deform. It’s always been described as round, one micron in diameter to grow in clusters like grapes on a vine.”
Soon after documenting this bizarre shape shifting behavior in a mouse model, Bentley initiated studies on human S. aureus infected bone specimens and in December of 2016, discovered the same bacterial phenomenon occurs in human bone.
The initial findings explain, among other things, why a staph infection in humans may return despite weeks or months of antibiotic treatments and bone debridement when replacing an infected implant. It also explains why infections can recur, sometime years – even decades – later, after going undetected in the patient.
Bentley will soon be a co-investigator in a P50 NIH-funded grant working with the principal investigator, Edward Schwarz, Ph.D., the director of the Center for Musculoskeletal Research and his team to continue studies on human S. aureus chronic osteomyelitis specimens.
“If we can identify a gene that allows S. aureus to shift into rod shaped bacteria, then maybe we can develop a drug to prevent invasion of osteocyte canaliculi and also recurrence,” she said.
Congratulations to Sarah Catheline for winning the People’s Choice Award at the University of Rochester’s Three Minute Thesis public competition held on May 11 at URMC.
Sarah is a fourth-year graduate student in the Pathways of Human Disease Ph.D. program and works in the lab of Dr. Jennifer Jonason. Her presentation, “Inhibiting Inflammaging to Treat Osteoarthritis (OA),” was one of eight to be accepted into the final round.
This year marks the second annual Three Minute Thesis public competition at the University of Rochester, which encourages participants to share their research in simple language that's both persuasive and easy for the average person to understand.
The event is open to current Ph.D. and professional doctorate (research) candidates in or beyond their third year of study. It’s also open to postdoctoral researchers. Winners receive travel awards ranging from $250-750.
The event is sponsored by the School of Medicine and Dentistry Center for Professional Development, the School of Arts, Science and Engineering Graduate Studies Office, the Graduate Student Society, and Graduate Student Association.
Three Minute Thesis Awards:
- Judge’s Winner: Thuy-vy Nguyen (Runner Up: Scott Friedland)
- People's Choice Award: Sarah Catheline
- Stephanie Carpenter: Solving the Mystery of Iron Chemistry
- Scott Friedland: Pancreatic Cancer and the Tale of the Broken Librarian
- Sarah Catheline: Inhibiting Inflammaging to Treat Osteoarthritis (OA)
- Claire McCarthy: Investigating the Toxicological Effects of Dung Biomass Smoke Exposure
- Taylor Moon: The New Epidemic
- Thuy-vy Nguyen: Solitude
- Manisha Taya: Understanding Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Dependent Cancer From Bed-Side to Bench and Back Again
- Janelle Veazey: Role of Protein Kinase D in Epithelial Cells During Respiratory Infection
Just about everyone who knew or worked with Dr. Marilyn Menegus (1943-2017) has a story about her.
There was the time she brought a Cheesy Eddie’s carrot cake to work when she got tired of hearing that her staff had never tried it before. A colleague recalled the way she could cut through complex scientific concepts and make them easy for anyone to understand. And her coworkers can remember how she’d warmly greet them with, “Hey kid,” no matter their age.
Dr. Menegus, known to many as, simply, Marilyn, passed away March 20, 2017 from complications resulting from colon cancer. Since then, the response from those who knew her has been felt deeply by many.
To celebrate her life and legacy, the Department of Pathology & Laboratory Medicine will host an informal event at the University of Rochester Medical Center on Friday, May 12.
Marilyn was an extremely accomplished and well respected microbiologist who joined the Department of Microbiology and Immunology in 1976 with a secondary appointment in Pathology & Lab Medicine.
She trained more than 40 clinical microbiology fellows and five infectious disease fellows during her 41 years at URMC, earning her the title of “mother of the post-doc program.” She stayed in contact with many of her past trainees, whom she treated like family. Many went on to work in prestigious laboratories across the U.S. Her impact on their professional lives remains strong.
“She was truly a mentor, always eager to share interesting clinical cases and inserting educational tidbits along the way,” said former fellow, Kristen Smith, Ph.D. “The depth of her knowledge and passion always amazed me.”
Former Pathology resident Vanesa Bijol, M.D., who now works in the Harvard University health system, said the sheer number of lives touched by Marilyn was huge. “In that sense, her professional impact was huge, and very few of us who devote life to academia can achieve that level of success,” Bijol wrote. “But she never thought of it that way. She just simply enjoyed her work, science, and teaching, and was very humble about her achievements.”
Marilyn was born and raised in Passaic, New Jersey with siblings, Dorothy and Herbert. She earned her bachelor’s degree from the College of Saint Elizabeth and later received her Ph.D. in virology from Cornell University in 1971.
In her early career, she established a clinical virology laboratory at St. Luke’s Hospital in New York City and also founded a clinical virology lab at URMC, which was one of the few of its kind in the U.S. during the late 1970s. During the course of her career, she published more than 100 articles and book chapters as an author and co-author.
She was an active member of organizations including the American Academy of Microbiology, and the American Society for Microbiology. In 2013 she received the Diagnostic Virology Award from the Pan American Society for Clinical Virology.
In what became one of her final professional contributions, Marilyn worked closely with the Finger Lakes Donor Recovery Network to establish a nucleic acid testing lab at Strong Memorial Hospital to significantly expedite the organ transplant process for organ recipients. This was launched successfully in February just weeks before her passing.
Rob Kochik, executive director of FLDRN, said he was heartbroken to hear the news of Marilyn’s death.
“She was always such a joy to work with,” he wrote. “She was committed to helping establish the NAT testing facility because she truly understood how vitally important it was to help the donation process.”
Despite her expertise and accomplishments, many remember Marilyn as an extremely approachable and down to earth person; a lover of gardening, food, wine, and a good joke.
Her brother describes her as “fiercely independent” and a rule breaker at heart. This was evidenced by one of her favorite movies, “Ferris Buehler’s Day Off,” and a stack of unpaid red light tickets.
An avid gardener, she once served as president of the Genesee Region Orchid Society and had more than 200 orchids in her house, in addition to a lush garden at her Rochester home where she lived with two cats, Bella and Luigi, and frequently hosted parties for friends.
Whether you knew her for 20 years or 20 minutes, Marilyn made a warm and lasting impression on the people she encountered at or outside of work. Debra Jesien, chief supervisor of Clinical Microbiology at URMC, worked closely with Marilyn for many years.
“She could bond with people very quickly,” said Jesien. “She was the type of person you could talk to once and you felt like you knew her.”
What: Memories of Marilyn, an informal memorial to celebrate the life of Dr. Marilyn Menegus. Guests are encouraged to bring their stories and photos to share.
When: Friday, May 12 from 12:00-2:00 p.m.
Where: LeChase Assembly Hall (G-9576) University of Rochester Medical Center. Drinks and light refreshments will be provided.
RSVP: Please follow this link to enter your RSVP online or contact Bethany Bushen for more information.
Read the obituary of Dr. Menegus in the Democrat and Chronicle
Jorge Yao, M.D. is a former URMC Pathology fellow-turned-faculty member. He first came in 2003 as a genitourinary pathology fellow and was offered a faculty position in 2004.
He worked closely with the Urology Department on research and clinical projects, helping to set up the institutional biospecimen repository. After a productive decade, he left in 2013 as an associate professor with an MBA from Simon Business School. He now works for Pathline Emerge in Ramsey, New Jersey.
Education & Training
Dr. Yao received his MD from University of the East - Ramon Magsaysay Memorial Medical Center and completed an internship in general medicine at St. Luke’s Medical Center in the Philippines. He did residency in pathology at Brooklyn Hospital Medical Center and Philippine General Hospital and completed internships in surgical pathology and cytopathology at New York University.
Where are you from originally?
I was born and raised in the Philippines and came to the U.S. to finish my training.
Wife, Grace Candelario
What first sparked your interest in pathology?
My uncle is a pathologist and visiting him at work sparked the interest, but I like anatomic pathology mainly because it is like being a consulting detective.
How would you describe your job to someone who’s never heard of it before?
I push around bits of people under the microscope then write a report about it.
How do you like to spend your free time? Do you have any hobbies/interests?
I have become a kaizen nerd lately, so most of my free time is spent reading and trying to find small improvements I can implement in my life. I used to have hobbies but they are getting together to file a class action suit for neglect.
What’s one piece of advice you have for up-and-coming pathology trainees looking to start their careers?
The best piece of advice I can give to new pathologists is that no matter how specialized the field becomes, there will always be a need for anatomic pathologists with a good grasp of basic pathology and an excellent foundation of general surgical pathology.
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