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URMC / Pathology & Laboratory Medicine / Our Faculty / Our Subspecialties / Bone and Soft Tissue Pathology

 

Bone and Soft Tissue Pathology

Clinical Service

Department Investigators

Brendan F. Boyce Osteoclast & osteoblast pathophysiology, preclinical models
Lianping Xing Osteoclast pathophysiology in arthritis
Robert A. Mooney Obesity/type2 diabetes & bone pathology
Ping Tang Bone metastasis of breast cancer
Zhenqiang Yao Bone cell regulation

Current Awards

Brendan F. Boyce Studies of the fate of the osteoclast (NIH)
Brendan F. Boyce 
(Co-Director, Lab Core)
UR core center for musculoskeletal biology and medicine (NIH)
Brendan F. Boyce 
(Project Director, Molecular Imaging Core)
Translating Molecular Signal Pathways to Orthopaedic Trauma Care
Brendan F. Boyce (Co-Investigator) Cellular dynamics at the synovium-bone interface in RA
Brendan F. Boyce
(Co-Investigator)
Osteoblast regulation in TNF-mediated bone loss
Brendan F. Boyce
(Co P.I.)
TRAF3 in age-related low-level chronic inflammation & osteoporosis (NIH)
Brendan F. Boyce
(Co P.I.)
UR Ventures: Bone targeted drug delivery
Brendan F. Boyce
(Co P.I.)
Development of novel bone-targeted chloroquine conjugates to prevent bone resorption
Lianping Xing Osteoblast regulation in TNF-mediated bone loss (NIH/NIAMS)
Lianping Xing Protein modification in bone cell regulation 
Lianping Xing Proteasomal regulation of osteoblasts
Lianping Xing Bone cells and lymphatic endothelium interface
Lianping Xing
(Co-Investigator)
The fate of the osteoclast
Lianping Xing
(Co-Investigator)
Cellular dynamics at synovium-bone interface in RA
Lianping Xing
(Co-Investigator)
TRAF3 in age-related low-level chronic inflammation & osteoporosis (NIH)
Lianping Xing
(P.I. for U.S.A. site)
Chinese traditional medicine in lymphangiogenesis
Lianping Xing
(Co-Investigator)
Bone targeted drug delivery
Zhenqiang Yao
(Co-Investigator)
TRAF3 in age-related low-level chronic inflammation & osteoporosis (NIH)

Interdepartmental Collaborations

Medicine/Endocrinology

Laura Calvi Hematopoietic-osteoblastic interactions

Orthopaedics (Center for Musculoskeletal Research)

Hani Awad Musculoskeletal tissue engineering, in vivo and in vitro
Jennifer Jonason Skeletal development,signaling mechanisms that govern stem cell differentiation
J. Edward Puzas Regulation of osteoblast activity
Eddie Schwarz Preclinical models of arthritis
Michael Zusick Chondrocytes and mechanisms of osteoarthritis

Rush University Medical Center

Di Chen Canonical Wnt signaling and mesenchymal stem cell differentiation

Allergy/Immunology/Rheumatology

Jennifer Anolik

Role of B cells in pathophysiology of human systemic lupus and the study of new immuno-modulatory treatments for lupus
Christopher Ritchlin Mechanisms of bone resorption and formation, the effect of anti-TNF agents on dendritic cell differentiation and the mechanisms for bone marrow edema in PsA and RA

Educational Opportunities

  • Center for Musculoskeletal Research faculty are thesis advisors for several students in our Pathology Ph.D. program
  • Drs. Boyce, Mooney and Xing participate in the Orthopaedics training grant (T32)
  • Orthopaedic case review conference

Clinical Highlights

  • Bone and soft tissue pathologists: Brendan Boyce, David Hicks, Xi Wang
  • Subspecialized bone histology lab for bone and soft tissue histopathology
  • Extensive immunohistochemistry panel
  • Full menu of clinical chemistry assays including bone disease related markers: P1NP; CTX; Urinary NTX; Intact PTH; 1, 25 dihydroxy vitamin D by tandem MS