Investigators Razia B. Akhtar, M.D. Improving survival and quality of care delivered to adolescents and young adults with cancer Quality improvement and delivery of investigational therapeutics to patients in the hospital and outpatient clinic setting Jeffrey R. Andolina, M.D., M.S. Principal investigator for Children's Oncology Group linical trials program Director, Pediatric Bone Marrow Transplantation Program. Novel approaches to stem cell transplantation including reduced-intensity conditioning regimens for malignant and nonmalignant disorders such as sickle cell disease and immune deficiencies. Lauren B. Bruckner, M.D., Ph.D. Survival and quality of care delivered to adolescents and young adults with cancer. Bone marrow transplantation: infections in the immune compromised host and mechanisms of acute lung injury following hematopoietic stem cell transplantation. Optimization of the electronic medical record for research and clinical care. Improving quality of care and resource utilization in hospitalized patients. Paul D. Kingsley, Ph.D. Embryonic Hematopoiesis Ontogeny of pematopoietic progenitors Erythroid differentiation and erythroid precursor self renewal David N. Korones, M.D Early implementation of supportive care including pain management, therapy side-effect control and psychosocial support for children with cancer. Clinical trials of new agents for children and adults with newly diagnosed and recurrent brain tumors Palliative and end-of-life care for children Kathleen E. McGrath, Ph.D. Research at the Palis Lab focuses on the ontogeny of the mammalian hematopoietic system. Formation of blood is a critical early event for mammalian embryos, initially occurring in the extraembryonic yolk sac of the gastrulating embryo, then migrating to the fetal liver, and finally homing to the bone marrow at the end of gestation. Our studies utilize the mouse embryo, adult bone marrow, and embryonic stem cells as primary model systems to investigate the initial appearance and differentiation of hematopoietic progenitors and precursors as well as their selective response to radiation damage. Craig A. Mullen, M.D., Ph.D. Division Chief Research mentoring: supporting fellows and junior faculty developing basic, translational and clinical research careers. Translational research in leukemia biology: by studying the interference with survival signals provided by bone marrow stroma to leukemia cells to prevent minimal residual disease and leukemia relapse, the aim is to identify immunological mechanisms that can be used to design therapies to prevent the recurrence of leukemia in pediatric patients following allogeneic HCS transplant. Newborn genetic screening for hemoglobinopathies Suzie A. Noronha, M.D. Newborn genetic screening for children with hemoglobin disorders Improving outcomes for patients with sickle cell disease: Transition of care among adolescents and young adults with sickle cell disease Health care access and delivery for patients with sickle cell disease Novel therapeutics to improve disease biology and symptom control James Palis, M.D. Basic science research on the molecular regulation of hematopoiesis: Cellular and molecular events underlying the initiation of hematopoiesis in the mammalian embryo Mechanisms regulating terminal differentiation of fetal and adult erythriod precursors Response of the erythroid lineage to radiation Olle Jane Z. Sahler, M.D. Chronic and terminal illness in children Sibling adaptation to childhood cancer Problem-solving skills training Cognitive remediation in cancer survivors The use of complementary medicine in allopathic practice Child and adolescent obesity Palliative and end-of-life care for children Jessica Shand, M.D., M.H.S. Translational research in leukemia immunobiology and the tumor microenvironment: Understanding how acute lymphoblastic leukemia escapes immune recognition Interfering with inflammatory signals released by chemotherapy-treated leukemia Collaborative research in the Children’s Oncology Group Young Investigator Program, working with investigators conducting research as part of the Leukemia Biology Committee.