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Pediatrics / Labs / Shand Research Lab / Current Projects / Role of Macrophages in Residual Leukemia Immune Escape

The Role of Macrophages in Residual Leukemia Immune Escape

We have observed that when macrophages encounter chemotherapy-treated leukemia cells from high-risk patients, signaling pathways that typically activate local T-cell immunity are suppressed. To understand how this “communication failure” between innate and adaptive immunity occurs, we are studying the role of pattern recognition receptors, such as Toll-like receptor 4, in shaping the macrophage inflammatory response to high-risk ALL cells.

Activated monocytes - Shand Lab

Photo Courtesy of the Shand Lab: Activated Monocytes