Past Student Research Topics 2015 Student Research Topics and Mentors Houda Abdelrahman, University of North Dakota School of Medicine and Health Sciences; "An assay for inducing APRIL production by intestinal epithelial cells to probe breastmilk’s immuno-modulatory effects." Mentor: Kirsi Jarvinen-Seppo, M.D., Ph.D. Mackenzie Cronin, University of Rochester, "Neonatal Oxygen Exposure leads to Altered Alveolar Epithelial Type-II cell pools, affecting the Response to Influenza A Virus at 2 week and 4 weeks of Age." Mentor: Michael O’Reilly, Ph.D.; William Domm, Ph.D. Lauren Edwards, University of Arizona; "Routine Assessment of Linear Growth in Preterm Infants." Mentors: Jeffrey Meyers, M.D.; Ronnie Guillet, M.D., Ph.D. Emily Fitzgerald, University of Rochester; "The Effect of Childhood Socioeconomic Stress on the Developing Innate Immune System." Mentor: Mary Caserta, M.D. Mahjub Hammond, University of Rochester School of Medicine and Dentistry; "Childhood Obesity Rates in Monroe County in 2012." Mentor: Stephen Cook, M.D., M.P.H. Danielle Hodges, Xavier University of Louisiana; "Improving the management of pediatric community-acquired pneumonia." Mentor: Eric Biondi, M.D., M.S.B.A. Samah Hoque, Cornell University; "Genetics of Congenital Heart Disease: Are Genes Deleted or Duplicated in Patients with Clinically Interpreted “Findings of Unknown Significance” Associated with Cardiac Development and Disease?" Mentor: Kate Ackerman, M.D. Francis James, Loyola Marymount University; "SOLVE-Brain: Identification of variations in novel genes for developmental brain disorders." Mentor: Alex Paciorkowski, M.D. Anya Joynt, University of Rochester; "Gene transfer of the Na+, K+-ATPase β1 subunit rescues mice with LPS-induced lung injury and upregulates adherens junction proteins." Mentor: David Dean, Ph.D. Benjamin Kasper, SUNY Buffalo Medical School; "Mesenchymal stromal cells isolated from pediatric lungs: analysis of viability, differentiation potential, and protein expression." Mentors: Gloria Pryhuber, M.D.; Ravi Misra, Ph.D. Faraz Khan, Stony Brook University School of Medicine, "Maturation of innate immune defense mRNA in the collecting duct." Mentors: George Schwartz, M.D.; Jeffrey Purkerson, Ph.D. Chinyere Okunji, University of Rochester School of Medicine and Dentistry; "The Financial Burden of Inflammatory Bowel Disease Healthcare Expenditure and Utilization in Pediatric Patients." Mentor: Lawrence Saubermann, M.D. Ashley Riley, Indiana University School of Medicine; "Maternal acidosis down-regulates beta-intercalated cell differentiation in progeny." Mentors: George Schwartz, M.D.; Jeffrey Purkerson, Ph.D. Rebecca Whitman, Cornell University; "Analysis of FOXF1 Gene Expression in an Alveolar Capillary Dysplasia Patient." Mentor: Laurie Steiner, M.D. 2014 Student Research Topics and Mentors Thomas Anderson, University of Rochester; "Isolating hybridoma isotype variants using fluorescence-activated cell sorting." Mentor: Dr. Francis Gigliotti, M.D. Erin S. Adonnino, University of Virginia; "Improving Measurements of Parents’ Understanding of Research Consent Forms." Mentor: Carl T. D’Angio, M.D. Yaakov Bishop, Boston University; "Bicarbonate secretion in immature rabbits is deficient despite pendrin expression in beta-intercalated cells." Mentor: George J. Schwartz, M.D. Jeff Clegg, University of Rochester School of Medicine and Dentistry; "Whole Exome Sequencing of Developmental Epilepsies." Mentor: Alex Paciorkowski, M.D. Kaitlyn Crossan, State University of New York at Fredonia; "Pediatric Subspecialist Knowledge and Behaviors Regarding Adolescent Contraception." Mentor: Susan M. Yussman M.D., M.P.H. Ayala Danzig, University of Rochester School of Medicine and Dentistry; "Identification of Social Emotional Problems Among Young Children Who Experience Adversity." Mentor: Peter G. Szilagyi, MD MPH; Anne-Marie Conn, Ph.D., M.Ed. Allison Eberhardt, University of Rochester; "Treatment of RUNX1-Mutated Acute Myeloid Leukemia with Focal Adhesion Kinase Inhibitors." Mentor: Jason Mendler, M.D., Ph.D. Merit P. George, Virginia Commonwealth University; "Validity of Home Portable Monitoring in the Diagnosis of Obstructive Sleep Apnea in Adolescents." Mentor: Heidi Connolly, M.D. Anisha Gundewar, University of Rochester; "Utilization of Preventive Asthma Visits among Urban Children with Persistent Asthma." Mentor: Jill Halterman M.D., M.P.H.; Maria Fagnano, M.P.H. Benjamin Kasper, SUNY Geneseo; "Optimization of Human Lung Cell Sorting and Identification Techniques." Mentor: Gloria Pryhuber, M.D. Zoe Kory, University of Rochester; "PRMT1 as a Novel Therapeutic Target in Chemoresistant Neuroblastoma." Mentor: Nina F. Schor, M.D. Ph.D., Xingguo Li, Ph.D. Kathryn Leyens, Upstate Medical University; "Differences Between Fetal and Adult Platelets." Mentor: James Palis, M.D. Shwetha Manjunath, University of Rochester School of Medicine and Dentistry; "PRC1 Complex is a Potential Regulator of Erythroid Self-Renewal in Stress Erythropoiesis." Mentor: James Palis, M.D. Natalie Martínez-Sosa, Ponce School of Medicine and Health Sciences; "Chorioamnionitis Induces Distinct Inflammatory and Regulatory Cytokine Changes in Premature Infant Cord Blood." Mentor: Kristin Scheible, M.D. Muranda Maurer, University of Pittsburgh at Johnstown; "SERPINE2 Deficiency Is Associated With Alterations In Lung Epithelial Cell Chemokine Expression And Lymphocyte Accumulation." Mentor: Thomas Mariani, Ph.D. Leti Nunez, University of Rochester; "Identifying the Median Lethal Dosage of Common Chemotherapy Drugs in Primary B-cell Acute Lymphoblastic Leukemia." Mentor: Craig Mullen M.D., Ph.D. Mira Patel, University of Alabama at Birmingham; "Elucidating Molecular Mechanisms Underlying EPO in the Developing Brain." Mentor: Laurie Steiner, M.D. Michelle Prong, Virginia Tech; "Patient and Provider Characteristics Associated With Nutrition, Physical Activity, and Screen Time Counseling in Monroe County Pediatric Practices." Mentor: Stephen Cook, M.D., M.P.H. Marika Psyhojos, Wellesley College; "Mutations in Cyclophilin-D, Mitochondrial Maturation, and Cardiomyocyte Differentiation in Neonatal Mice." Mentor: George Porter, M.D., Ph.D. Russell Salamo, University of Arkansas; "Exploring the Effect of Ectopic Activation of Hh Signaling on the Differentiation of the Alveolar Epithelium." Mentor: Kate Ackerman, M.D. Carmen Shin, Mount Holyoke College; "Implementation of an integrated care pathway decreases length of stay for children with asthma." Mentor: Eric A. Biondi, M.D. 2013 Student Research Topics and Mentors John Dawson, University of Rochester; “A Best Practice for Mosquito Net Usage: Lessons learned from community based participatory research in Senegal” Mentor: C. Andrew Aligne, M.D., M.P.H. Gregory Golembeski, University of Rochester; “Morning Blood Pressure Surge in Children Evaluated for Hypertension.” Mentor: Marc Lande, M.D. Layla Hatem, Jefferson Medical College; “The Effect of Maternal Smoking on Oxidative Stress in the Infant.” Mentor: Gloria S. Pryhuber, M.D. Katie Hockensmith, Drury University; “Immunoprecipitation of ATP synthase using c subunit antibodies.” Mentor: George A. Porter, Jr., M.D., Ph.D. Faraz Khan, RIT; “Isolation of cortical collecting ducts from rabbit kidney by laser capture microdissection.” Mentor: George Schwartz, M.D. Rakhee Lalla, University of New England College of Osteopathic Medicine; “The Impact of Preoperative Imaging on the Efficiency of Care for Pediatric Appendicitis.” Mentor: Yi-Horng, Lee, M.D. Emily Leubner, University of Pittsburgh; “Elucidating the mechanism underlying the protective effects of erythropoietin in the developing brain.” Mentor: Laurie Steiner, M.D. Nicklaus Lewis, North Carolina Central University; “Trends in Adolescent Opioid Misuse by Race and Population Density.” Mentor: Leesha Hoilette, M.D., M.Sc. David Luor, Rutgers University; “Inter-observer reliability between attending physicians and bedside nurses when using a respiratory score.” Mentor: Eric Biondi, M.D. Mandy (Hei) MA, University at Buffalo School of Medicine; “The Global Developmental Inventory: A novel assessment tool applied to children with FOXG1-related disorders.” Mentor: Alex Paciorkowski, M.D. John (Jay) Petosa, St. Lawrence University; “Treatment of Obstructive Sleep Apnea with Adenotonsillectomy Compared to CPAP Results in Better Quality of Life in Overweight/Obese Children & Adolescents.” Mentor: Heidi Connelly, M.D. Jonathan Pierce, St. Bonaventure University; “The Effect of Macrophage Phenotype on Phagocytosis of Pneumocystis.” Mentor: Francis Gigliotti, M.D. Taylor Streeter, Tougaloo College; “Effect of Quiet or Listening to Music while Breastfeeding on the Production and Lipid and Sodium Content of the Milk.” Mentor: Ruth Lawrence, M.D. Kathryn Voss, College of William and Mary; “Update of Monroe County Childhood Obesity Rate.” Mentor: Stephen Cook, M.D., M.P.H. Chantelle White, University of Rochester; “Investigation of Cardiac Morphology in a Mouse Model with a Congenital Defect.” Mentor: Kate Ackerman, M.D. Claire Wyman, University of Rochester; “Respiratory Pathogens in Premature and Term Newborns Determined by TaqMan Low Density Array Cards (TAC).” Mentor: Mary T. Caserta, M.D. Chelsea Young, University of Connecticut; “Inhibition of Stat3 Signaling in Primitive and Definitive Erythropoiesis.” Mentor: James Palis, M.D. 2012 Student Research Topics and Mentors August Anderson, The College of William and Mary. "Anti-Cryptococcal Molecules alter Vacuolar and Endocytic Membranes." Mentor: Damian Krysan, MD, PhD. Asad Arastu, University of Rochester. "Identifying Human Homologues in Pneumocystis jiriveci to Regions of A12 Protein from Mouse Pneumocystis." Mentor: Francis Gigliotti, MD. Mohammad Bawany, St. John Fisher College. "Improving Measurement of Parents' Understanding of Research Permission."Mentor: Carl D'Angio, MD. Paul Carlson, University of Minnesota. "Analysis of the Role of Zfpm2 (Fog2) in Early Lung Maturation." Mentor: Kate Ackerman, MD. Alyssa Cohen, University of Rochester Medical School. "Asthma Medication Adherence among Urban Teens: Barriers, Facilitators and Experiences with School-Based Care." Mentor: Jill Halterman, MD, MPH. Haggerty-Friedman Summer Scholar Margaret Connolly, Tufts University School of Medicine. "Different Lineages of Erythropoiesis Arise from Human Embryonic Stem Cells." Mentor: James Palis, MD. Dawling Dionisio Santos, University of Puerto Rico. "Role of Autophagy Regulator BE-clin-1 in Endothelial Cell Inflammation." Mentor: Arshad Rahman, PhD. Christine Kang, University of Maryland. "Assessment of Respiratory Function in Preterm Infants Using Tidal Breathing Analysis." Mentor: Clement Ren, MD. Alana Koehler, Ithaca College. "COD OIL: Challenges Obtaining Dietary Omega-3 Intake Levels. Comparison of Intake in Children with Typical Development and Autism." Mentor: Susan Hyman, MD. Ryan Larochelle, Bowdoin College. "Regulation of Anion Exchanger Expression and Distribution in the Renal Cortical Collecting Duct during Acidosis." Mentor: George Schwartz, MD. Elizabeth Ojukwu, University of Massachusetts Medical School. "Facilitators and Barriers to Becoming Patient Centered Medical Homes Within Community Health Centers in New York State." Mentor: Leesha Hoilette, MD, MS. John J. Petosa, Jr., St. Lawrence University. " Pediatric Intensive Care Courses Post-Adenotonsillectomy: An Algorithm for Efficient Referral." Mentor: Heidi Connolly, MD. David Quinzi, Cornell University. "Parks, Recreation Centers and Areas for Play: Effect on Weight Status for Children and Adolescents in Monroe County." Mentor: Stephen Cook, MD, MPH. Rebecca Sharma, Cornell University. "Assessing a Developmental Screening Program in Primary Care." Mentor: Heather Paradis, MD, MPH. Henry Su, Williams College. "The Effects of Preoperative Imaging on Surgical Outcomes for Pediatric Appendicitis Patients." Mentor: Yi-Horng Lee, MD. Xinxin Zhang, Wake Forest University. "Health Models for Foster Care: Benefits and Challenges: A Descriptive Paper on Health Care Models for Children in Foster Care." Mentor: Sandra Jee, MD, MPH. 2011 Student Research Topics and Mentors Sravya Brahmandam, NEOUCOM. "Role of ER Chaperone and Signaling Regulator GRP78/BiP in Endothelial Cell Inflammation." Mentor: Fabeha Fazal, PhD. Usa Cain, Boston University Medical School. "Mealtime Behavior and Nutrition in Children with Autism: How Does Behavior Affect Nutrient Intake and Body Mass Index?" Mentor: Susan Hyman, MD Haggerty-Friedman Summer Scholar Margaret Connolly, Boston College. "TM for TMs: Reliability of Telemedicine Images for Middle-Ear Problem Diagnosis." Mentor: Kenneth McConnochie, MD, PhD. Ysabella Esteban, Seton Hall University. "Neonatal Hyperoxia Has Long Term Disruptive Effects in Mouse Neurodevelopment." Mentor: Michael O'Reilly, PhD. Leah Gacioch, University of Michigan. "Follow-Up Chart Review from Obesity Learning Collaborative." Mentor: Stephen Cook, MD. Meredith Goodloe, University of Maryland School of Medicine. "The Role of Kupffer Cells in Acute Liver Injury Induced by Exogenous Airway TNF-a." Mentor: Gloria Pryhuber, MD. Cara Hall, Pomona College. "Basal Ganglia Role in the Preparation or Execution of Cue-Dependent Movement Strategies." Mentor: Jonathan Mink, MD, PhD. Bryce Kanter, Gonzaga University. "Regulation of Endothelial Cell Inflammation by Transglutaminase 2." Mentor: Arshad Rahman, PhD. Viki Katsetos, St. John Fisher College. "Adolescent and Parent Media Preferences for Immunization Reminders." Mentor: Cynthia Rand, MD, MPH. Benjamin Mazer, University of Rochester. "Breath of Hope: A Community Wide Care Coordination Program for Asthma." Mentors: Christine Burns, EdM, MBA and Janice Schriefer, MBA, PhD. Aditi Mulgund, NEOUCOM. "The Master Regulator HIF-1a Undergoes Physiologically-Regulated Cleavage." Mentor: Marc Halterman, MD, PhD. Abimbola Olutimehin, University of Pittsburgh. " A Descriptive Analysis of Access to Dental Care and Dental Health of Non-Diabetic Children." Mentor: Leesha Hoilette, MD, MS. Veronica Petrash, Grand Valley State University. "PLUNC Expresssion in Bronchiopulmonary Dysplasia and in Lung Epithelial Cells." Mentor: Thomas Mariani, PhD. Jennifer PIer, SUNY Buffalo Meidcal School. "Secondhand Tobacco Smoke Exposure and Serum Cytokine Levels in Healthy Children." Mentor: Karen Wilson, MD, MPH. Courtney Soley, Indiana University Medical School. "Changes in Mitochondrial Structure and Function During Embryonic Cardiac Development." Mentor: George Porter, Jr., MD, PhD. Kelcie Sprentall, SUNY Upstate Medical University. "Scoring Respiratory Events During Sleep-What To Do When Nasal Airflow Data is Absent?" Mentor: Heidi Connolly, MD. Shufan Sun, University of Rochester. "Candida Albicans Evade Host Immune Response by Degrading Superoxide but not Nitric Oxide." Mentor: Melanie Wellington, MD, PhD. Toby Terwilliger, SUNY Geneseo. "Expression of an Optimized Corss-Species Antigen of Pneumocystis for Evaluation as a Potential Vaccine." Mentors: Francis Gigliotti, Md, and Terry Wright, PhD. 2010 Student Research Topics and Mentors William Alexander, "Essential Role of Phospholipase C Epsilon in Regulating Thrombin-Induced NF-kB Activation and Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells." Maryville College. Mentor: Arshad Rahman, PhD. Geetha Bhagavatula, "The Effect of Age, Gender and Ferritin Levels on Restless Leg Syndrome Symptoms in Children." St. Bonaventure University. Mentor: Heidi Connolly, MD. Ryan Busha, "Evaluation of a Childhood Obesity Prevention Program: Greater Rochester Healthy Child Care 2010, 12 Month Follow-up." Duquesne University. Mentors: Stephen Cook, MD, MPH and Marjorie Allan Allison Canfield, "Communication Emotion: The Impact of Gesture and Facial Expressions." University of Rochester. Mentor: Laura Silverman, PhD. Peiwen Chen, "Role of Traf1 in Silica-Induced Apoptosis in Mouse Lung." SUNY Buffalo. Mentor: Gloria S. Pryhuber, MD. Si Xiao Chen, "PROPHENO Pilot Seizure Cession, Compliance Assessment." Clarkson University. Mentors: Ronnie Guillet, MD, PhD, and Jennifer Kwon, MD. Jennifer Cirino, "Prevelance of Psychotropic Medication for Hypertension." SUNY Buffalo Medical School. Mentor: Marc Lande, MD. Haggerty-Freidman Summer Scholar. Robert Cooper, "Activation of mTOR During Host Cell Infection with Spotted Fever and Typhus Rickettsia." SUNY Geneseo. Mentor: Sanjeev Sahni, PhD. Thomas Dieringer, "Investigation of Folding and Trafficking of Hensin in an Intercalated Epithelial Cell Line." University of Rochester. Mentor: George Schwartz, M.D. and Soundarapandian Vijayakumar, PhD. Harsh Desai, "Clinical Outcomes in Infants with Cystic Fibrosis Transmembrane Conductance Regulator Related Metabolic Syndrome." Salisbury University. Mentor: Clement Ren, M.D. Jason Fishel, "Engaging Community-Based Research and Advocacy." Carnegie Mellon University. Mentors: Stephen Cook, MD, MPH and Kathy Lewis. Jacquelyn Gonka, "Quality of Care in Two Medical Homes for Foster Care." SUNY Buffalo. Mentor: Sandra Jee, MD, MPH. Haggerty-Friedman Summer Scholar. Charles Hannum, "Food Dyes, Behavior and Autism: Does What Children Eat Color Behavior?" SUNY Upstate Medical School, Syracuse. Mentor: Susan Hyman, MD. Nicole Hook, "Characterization of the Expression of Acid-Base Transporters in an Immortalized Intercalated Cell Line." Rochester Institute of Technology. Mentor: Soundarapandian Vijaykumar, PhD. Michael Maher, "Development of an Acid Secreting Phenotype in an Intercalated Cell Line." Carthage College. Mentors: Jeffrey Purkerson, PhD and George Schwartz, MD Aditi Mulgund, "Developmental Abnormalities in the Rat Model of Autosomal Recessive Polycystic Kidney Disease." NEOUCOM. Mentor: Soundarapandian Vijaykumar, PhD. Jennifer Pier, "The Effect of Environmental Tabacco Smoke Exposure on Severity of Influenza in Pediatric Inpatient Population." Nazareth College. Mentor: Karen Wilson, MD, MPH. Lisa Ratanaprasatporn, "The Role of PKC in Strain Induced Signaling in Pulmonary Epithelial Cells." Alpert Medical School Brown University. Mentor: Patricia Chess, MD. Courtney Soley, "Mitochondiral Structure and Function During Cardiac Myocyte Differentiation'." Valparaiso University. Mentor: George Porter, Jr., MD, PhD. Melanie Wooten, "The Effects of Family Structure on an Adolescents's Perception of Food and Physical Activity." Georgia College and State University. Mentor: Leesha Hoilette, MD.