Leukemia-induced "Danger Signals"
Immunologic “danger signals” are proteins typically secreted by pathogen-infected or otherwise damaged cells to recruit the professional scavenger and cytotoxic cells of the immune system. We have observed that chemotherapy-treated leukemia cells, particularly from high-risk patients, produce “danger signal” that suppresses, rather than activates, inflammatory signaling. We are studying how this signal is made by leukemia cells, how it is modified in the microenvironment and identifying it’s critical downstream receptors to design therapies that reverse suppressive effects and improve host immune surveillance of microscopic residual disease.
Image Courtesy of the Shand Lab: NFkB Silencing