Fellowship Research Recent Graduate Katherine Ebsworth-Mojica, M.D. Research Interest Development of anti-microbial agents for the therapeutic intervention of multi-drug resistant bacteria Research Mentors Paul Dunman, Ph.D. Martin Pavelka, Ph.D. Nancy D. Connell, Ph.D. Damian J. Krysan, M.D., Ph.D. Jennifer Nayak, M.D. John Treanor, M.D. Publications Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. Repurposing the Antihistamine Terfenadine for Antimicrobial Activity Against Staphylococcus Aureus. Journal of Medicinal Chemistry. 2014. 57(20), 8540-8562. Forbes L, Ebsworth-Mojica K, DiDone L, Li S, Freundlich JS, Connell N, Dunman PM, Krysan DJ. A High Throughput Screening Assay for Anti-mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Death. PLOS One. May 14, 2015. Awards and Funding Travel Grant, Pediatric Infectious Disease Society, January 2016. Graduates Zachary Hoy, M.D. Research Interest Role of macrophage in protection from Pneumocystis Publications/Abtracts Hoy Z, Dodds-Ashley ES, Weinberg GA, Krysan DJ. The Pediatric Infectious Diseases Consultant: Voriconazole Therapeutic Drug Monitoring. Journal of Pediatric Infectious Diseases Society. 2014 Sep; 3(3):270-1. Epub 2014 Mar 30. Zhang ZQ, Wang J, Hoy Z, Keegan A, Bhagwat S, Gigliotti F, Wright TW. Neither Classical nor Alternative Macrophage Activation Is Required for Pneumocystis Clearance during Immune Reconstitution Inflammatory Syndrome Infection and immunity. Infection and Immunity. 2015 83(12):4594-603. Epub 2015 Sep 14. Hoy Z and Tesini. Pneumocystosis. In Gamble, K.C., and M.M. Clancy (eds). Infectious Diseases of Concern to Captive and Free Ranging Animals in North America, 2nd ed. 2013. Infectious Disease Committee, American Association of Zoo Veterinarians, Yulee, Florida. 1098 pp. Awards and Funding Clausen Fellowship Award, Strong Children's Research Center, University of Rochester Medical Center, 2013-2014. Brenda Tesini, M.D. Research Interest Analysis of a prototype Pneumocystis vaccine Publications/Abtracts Warren HS, Fitting C, Hoff E, Abid-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM. Resilience to Bacterial Infection: Difference Between Species Could Be Due to Proteins in Serum. J Infect Dis. 2010 Jan 15; 201(2):223-32. Liang M, Bagchi A, Warren HS, Tehan M, Trigilio J, Beasley-Topliffe L, Tesini B, Lazzaroni JC, Fenton M, Hellman J. Bacterial Peptidoglycan-Associated Lipoprotein: A Naturally Occurring Toll-Like Receptor 2 Agonist that is Shed into Serum and Had Synergy with Lipopolysaccharide. J Infect Dis. 2005 March; 191(6):939-48. Tesini B, Epstein L and Caserta M. Clinical Impact of Primary Infection with Roseolovirsues. Curr Opin Virol. 2014 Dec 9; 91-6. Hoy Z. and Tesini B. Pneumocystosis. In Gamble, K.C., and M.M. Clancy (eds). Infectious Diseases of Concern to Captive and Free Ranging Animals in North America, 2nd ed. 2013. Infectious Disease Committee, American Association of Zoo Veterinarians, Yulee, Florida. 1098 pp. Awards and Funding Travel Award, NIAID/IDSA Infectious Diseases Research Careers Meeting, May 2014 Clausen Fellowship Award, Strong Children's Research Center, University of Rochester Medical Center, 2013-2014. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Infectious Diseases Fellows Program Award, American Society for Microbiology, Washington, DC, September 2014. Mundeep Kainth, D.O., M.P.H. Research Interest Child health study: Vaccine Responses Publications / Abstracts Kainth MK, et al. Chromosomally integrated HHV-6 and HIV disease progression. NIH- NIAID-IDSA Research Careers Meeting. Bethesda, MD. 2012 May 18. Kainth MK, Caserta MT. Molecular diagnostic tests for human herpesvirus 6. Pediatr Infect Dis J. 2011 Jul;30(7):604-5. Kainth MK, Krysan DJ. Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school age children. J Pediatr. 2011;158(3):515-6. Kainth MK, D’Angio C. Newborn immunizations: The hepatitis B paradigm, case #924. University of Rochester Medical Center, Peri-FACTS Academy. Rochester, NY: 2010. Awards and Funding Ruth L. Kirschstein National Research Service Award – T32, Pediatric Infectious Diseases. PI: Frank Gigliotti, M.D., 2010. Bradford Fellowship. Strong Children's Research Center, University of Rochester Medical Center. 2010. Jennifer L. Nayak, M.D. Research Interest Evaluation of the diversity of the CD4 response to influenza in C57BL/10 mice Publications / Abstracts Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine. J Infect Dis. 2013 Jan 15;207(2):297-305. Nayak JL, Sant AJ. Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host. Immunology. 2012 Aug;136(4):425-36. Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ. The utility and limitations of current web-available algorithms to predict peptides recognized by CD4 T-cells in response to pathogen infection. J Immunol. 2012 May 1;188(9):4235-48. Nayak JL, Sant AJ. T cell immunology for the clinician. Pediatr Infect Dis J. 2011 Mar 13;30(3):248-250. Nayak JL, Richards KA, Chaves FA, Sant AJ. Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveal dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol. 2010 Apr;23(2):169-80. Nayak JL, Hall C. Bronchiolitis. BMJ Point of Care Monograph. 2009. Nayak JL, Treanor JJ. Antiviral treatment and prophylaxis of influenza virus in children. Pediatric Ann. 2009 Dec;38(12):667-74. Nayak JL, Gigliotti F. Methicillin-resistant staphylococcus aureus and obstetric infections, Case # 788. The University of Rochester Medical Center, Peri-FACTS Academy. Rochester, NY: 2008.