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Barbara H. Iglewski, Ph.D.

Barbara H. Iglewski, Ph.D.

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Call Center (585) 276-3000

About Me

Professional Background

Dr. Barbra Iglewski is Professor of Microbiology and Immunology and Director of International Programs at the University of Rochester Medical Center. She was the Chair of the Department of Microbiology and Immunology from 1986-2009 and the Vice Provost for Research and Graduate Education at the U...
Dr. Barbra Iglewski is Professor of Microbiology and Immunology and Director of International Programs at the University of Rochester Medical Center. She was the Chair of the Department of Microbiology and Immunology from 1986-2009 and the Vice Provost for Research and Graduate Education at the University of Rochester from 1995-1998.

Faculty Appointments

Professor Emeritus - Department of Microbiology and Immunology (SMD)

Credentials

Education

PhD | Penn State University. Microbiology, All Other. 1964

MS | Penn State University. Microbiology, All Other. 1962

BS | Allegheny College. Biology. 1960

Awards

Lifetime Mentor Award. 2009

NIH Health Merit Award R37. 2001 - 2010

Susan B. Anthony, Lifetime Achievement Award. 2001

Arthur Kornberg, Research Award. 1999

Alice Evans Award, American Society for Microbiology. 1994

John W. Bullard Lecturer; Uniformed Services University of Health Sciences. 1992

Honorary Lifetime Member - Sigma Delta Epsilon. 1987

Fellow, American Academy of Microbiology. 1986

Research

Dr. Iglewski has made many important contributions to the field of Pathogenic Microbiology and is best known for her elucidation of the molecular mechanism of action of Pseudomonas toxin A, the discovery of various other toxins and exoenzymes including the first type 3 secreted Pseudomonas toxin (ex...
Dr. Iglewski has made many important contributions to the field of Pathogenic Microbiology and is best known for her elucidation of the molecular mechanism of action of Pseudomonas toxin A, the discovery of various other toxins and exoenzymes including the first type 3 secreted Pseudomonas toxin (exo S) and her landmark discovery that a type I quorum sensing system was a global regulator of virulence in a human pathogen. Dr. Iglewski has published over 150 research papers and book chapters and served as an editor of a number of books including the Encyclopedia of Microbiology. Dr. Iglewski is recognized by the Institute of Scientific Information as a highly cited scientist. This group comprises less than 0.5% of all publishing researchers. Her current research projects, supported by a merit award from the NIH, focus on the regulation of virulence and biofilm development in Pseudomonas aeruginosa.

Patents

Autoinducer Molecule

Issue date: January 07, 1997

Patent #: 5,591,872

Country: United States

Inventors: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Immunogenic Conjugates of Gram Negative Bacterial Autoinducer Molecules and Antibodies Raised Against the Same

Issue date: May 28, 2002

Patent #: 6,395,282

Country: United States

Inventors: Barbara H Iglewski, Richard P Phipps

Methods and Compositions for Controlling Biofilm Development

Issue date: September 24, 2002

Patent #: 6,455,031

Country: United States

Inventors: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Autoinducer Molecule

Issue date: May 02, 2000

Patent #: 6,057,288

Country: United States

Inventors: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Homoserine Lactones Biofilm Regulating Compounds and Thier Methods of Use.

Issue date: October 17, 2002

Patent #: 753,329

Country: Australia

Inventors: Barbara H Iglewski, James P Pearson

Autoinducer Molecule

Issue date: August 30, 2005

Patent #: 6,936,447

Country: United States

Inventors: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Homoserine Lactones Biofilm Regulating Compounds and Their Methods of Use

Issue date: January 27, 2009

Patent #: 2,294.586

Country: Canada

Inventors: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Antibodies Raised Against Immunogenic Conjugates of Gram-Negative Bacterial Autoinducer Molecules

Issue date: March 30, 2004

Patent #: 6,713,059

Country: United States

Inventors: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

Method for Detecting a Gram-Negative Bacterial Autoinducer Molecule

Issue date: October 25, 2005

Patent #: 6,958,219

Country: United States

Inventors: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

Autoinducer Molecules and Uses Therefor

Issue date: October 28, 2008

Patent #: 7,442,798

Country: United States

Inventors: Pesci C Everett, Everett P Greenberg, Barbara H Iglewski, Andrew S Kende, Jared B Milbank, James P Pearson

Homoserine Lactones Biofilm Regulating Compounds and Their Methods of Use

Issue date: October 18, 2006

Patent #: 0994961

Country: Europe

Inventors: Barbara H Iglewski, James P Pearson

Methods of Treating or Preventing an Infectious Disease Using an Immunogenic Conjugate of a Gram-Negative Bacterial Autoinducer Molecule

Issue date: June 10, 2008

Patent #: 7,384,639

Country: United States

Inventors: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

Methods and Compositions for Controlling BioFilm Development

Issue date: August 22, 2006

Patent #: 7,094,394

Country: United States

Inventors: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Publications

Journal Articles

Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa.

Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH

Infection and immunity.. 2009 October 77 (10):4446-54. Epub 08/03/2009.

P. aeruginosa Biofilms in CF Infection.

Wagner VE, Iglewski BH

Clinical reviews in allergy & immunology.. 2008 December 35 (3):124-34. Epub 1900 01 01.

Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner.

Morici LA, Carterson AJ, Wagner VE, Frisk A, Schurr JR, Höner zu Bentrup K, Hassett DJ, Iglewski BH, Sauer K, Schurr MJ

Journal of bacteriology.. 2007 November 189 (21):7752-64. Epub 08/31/2007.

Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa.

Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG

Infection and immunity.. 2007 August 75 (8):3780-90. Epub 05/25/2007.

Regulation of the Pseudomonas aeruginosa quorum-sensing regulator VqsR.

Li LL, Malone JE, Iglewski BH

Journal of bacteriology.. 2007 June 189 (12):4367-74. Epub 04/20/2007.

Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa.

Wagner VE, Li LL, Isabella VM, Iglewski BH

Analytical and bioanalytical chemistry.. 2007 January 387 (2):469-79. Epub 12/01/2006.

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM, Superfine R, Rubinstein M, Iglewski BH, Boucher RC

Proceedings of the National Academy of Sciences of the United States of America.. 2006 November 28103 (48):18131-6. Epub 11/20/2006.

Quorum sensing: dynamic response of Pseudomonas aeruginosa to external signals.

Wagner VE, Frelinger JG, Barth RK, Iglewski BH

Trends in microbiology.. 2006 February 14 (2):55-8. Epub 01/06/2006.

Identification of Pseudomonas aeruginosa Genes Involved in Virulence and anaerobic Growth. Infect. and Immun. 74, 4237-4245, 2006.

Filatrault, M.J., Picardo, K.F., Ngai, H., Passador, L. and Iglewski, B.H.

Infect. and Immun. 2006; .

Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa.

Filiatrault MJ, Wagner VE, Bushnell D, Haidaris CG, Iglewski BH, Passador L

Infection and immunity.. 2005 June 73 (6):3764-72. Epub 1900 01 01.

Azithromycin Exhibits Bactericidal Effects on Pseudomonas aeruginosa through Interaction with the Outer Membrane. Antimicrob Agents Chemother. 2005 Apr;49(4):1377-80.

Imamura Y, Higashiyama Y, Tomono K, Izumikawa K, Yanagihara K, Ohno H, Miyazaki Y, Hirakata Y, Mizuta Y, Kadota J, Iglewski BH, Kohno S.

Antimicrob Agents Chemother. 2005; .

Molecular Basis of Azithromycin-resistnat Pseudomonas aeruginosa Biofilms. Antimicrobial. Agents and Chemo. In press, Sept 2005.

Gillis, R.J. ,White,K.G., Choi,K-H., Wagner, W.E., Schwietzer, H.P.,and Iglewski, B.H.

Agents and Chemo. 2005; .

Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa.

Wagner VE, Gillis RJ, Iglewski BH

Vaccine.. 2004 December 622 Suppl 1 :S15-20. Epub 1900 01 01.

Azithromycin retards Pseudomonas aeruginosa biofilm formation.

Gillis RJ, Iglewski BH

Journal of clinical microbiology.. 2004 December 42 (12):5842-5. Epub 1900 01 01.

Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target.

Smith RS, Iglewski BH

The Journal of clinical investigation.. 2003 November 112 (10):1460-5. Epub 1900 01 01.

Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment.

Wagner VE, Bushnell D, Passador L, Brooks AI, Iglewski BH

Journal of bacteriology.. 2003 April 185 (7):2080-95. Epub 1900 01 01.

P. aeruginosa quorum-sensing systems and virulence.

Smith RS, Iglewski BH

Current opinion in microbiology.. 2003 February 6 (1):56-60. Epub 1900 01 01.

Functional domains of the Rh1R transcriptional regulator of Pseudomonas aeruginosa. J. Bacteriol. 185:7129-7139, 2003.

Lamb, J.R., Patel, H., Montiminy, T., Wagner, V.E., and Iglewski, B.H.

J. Bacteriol. 2003; .

Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis.

Yoon SS, Hennigan RF, Hilliard GM, Ochsner UA, Parvatiyar K, Kamani MC, Allen HL, DeKievit TR, Gardner PR, Schwab U, Rowe JJ, Iglewski BH, McDermott TR, Mason RP, Wozniak DJ, Hancock RE, Parsek MR, Noah TL, Boucher RC, Hassett DJ

Developmental cell.. 2002 October 3 (4):593-603. Epub 1900 01 01.

The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.

Smith RS, Kelly R, Iglewski BH, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2002 September 1169 (5):2636-42. Epub 1900 01 01.

Role of the Pseudomonas aeruginosa las and rhl quorum-sensing systems in rhlI regulation.

de Kievit TR, Kakai Y, Register JK, Pesci EC, Iglewski BH

FEMS microbiology letters.. 2002 June 18212 (1):101-6. Epub 1900 01 01.

IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2.

Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2001 July 1167 (1):366-74. Epub 1900 01 01.

Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.

De Kievit TR, Parkins MD, Gillis RJ, Srikumar R, Ceri H, Poole K, Iglewski BH, Storey DG

Antimicrobial agents and chemotherapy.. 2001 June 45 (6):1761-70. Epub 1900 01 01.

Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns.

De Kievit TR, Gillis R, Marx S, Brown C, Iglewski BH

Applied and environmental microbiology.. 2001 April 67 (4):1865-73. Epub 1900 01 01.

Inhibition of quorum sensing by a Pseudomonas aeruginosa dksA homologue.

Branny P, Pearson JP, Pesci EC, Köhler T, Iglewski BH, Van Delden C

Journal of bacteriology.. 2001 March 183 (5):1531-9. Epub 1900 01 01.

Gene expression in Pseudomonas aeruginosa: evidence of iron override effects on quorum sensing and biofilm-specific gene regulation.

Bollinger N, Hassett DJ, Iglewski BH, Costerton JW, McDermott TR

Journal of bacteriology.. 2001 March 183 (6):1990-6. Epub 1900 01 01.

Bacterial quorum sensing in pathogenic relationships.

de Kievit TR, Iglewski BH

Infection and immunity.. 2000 September 68 (9):4839-49. Epub 1900 01 01.

Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa.

Rashid MH, Rumbaugh K, Passador L, Davies DG, Hamood AN, Iglewski BH, Kornberg A

Proceedings of the National Academy of Sciences of the United States of America.. 2000 August 1597 (17):9636-41. Epub 1900 01 01.

Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.

Pearson JP, Feldman M, Iglewski BH, Prince A

Infection and immunity.. 2000 July 68 (7):4331-4. Epub 1900 01 01.

The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa.

McKnight SL, Iglewski BH, Pesci EC

Journal of bacteriology.. 2000 May 182 (10):2702-8. Epub 1900 01 01.

Novel synthetic analogs of the Pseudomonas autoinducer.

Kline T, Bowman J, Iglewski BH, de Kievit T, Kakai Y, Passador L

Bioorganic & medicinal chemistry letters.. 1999 December 209 (24):3447-52. Epub 1900 01 01.

Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide.

Hassett DJ, Ma JF, Elkins JG, McDermott TR, Ochsner UA, West SE, Huang CT, Fredericks J, Burnett S, Stewart PS, McFeters G, Passador L, Iglewski BH

Molecular microbiology.. 1999 December 34 (5):1082-93. Epub 1900 01 01.

Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections.

Rumbaugh KP, Griswold JA, Iglewski BH, Hamood AN

Infection and immunity.. 1999 November 67 (11):5854-62. Epub 1900 01 01.

Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa.

Pesci EC, Milbank JB, Pearson JP, McKnight S, Kende AS, Greenberg EP, Iglewski BH

Proceedings of the National Academy of Sciences of the United States of America.. 1999 September 2896 (20):11229-34. Epub 1900 01 01.

RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa.

de Kievit T, Seed PC, Nezezon J, Passador L, Iglewski BH

Journal of bacteriology.. 1999 April 181 (7):2175-84. Epub 1900 01 01.

Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility.

Glessner A, Smith RS, Iglewski BH, Robinson JB

Journal of bacteriology.. 1999 March 181 (5):1623-9. Epub 1900 01 01.

Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals.

Pearson JP, Van Delden C, Iglewski BH

Journal of bacteriology.. 1999 February 181 (4):1203-10. Epub 1900 01 01.

Quorum sensing, gene expression, and Pseudomonas biofilms.

De Kievit TR, Iglewski BH

Methods in enzymology.. 1999 310 :117-28. Epub 1900 01 01.

Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant.

Van Delden C, Pesci EC, Pearson JP, Iglewski BH

Infection and immunity.. 1998 September 66 (9):4499-502. Epub 1900 01 01.

The involvement of cell-to-cell signals in the development of a bacterial biofilm.

Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP

Science.. 1998 April 10280 (5361):295-8. Epub 1900 01 01.

Cell-to-cell signaling and Pseudomonas aeruginosa infections.

Van Delden C, Iglewski BH

Emerging infectious diseases.. 1998 4 (4):551-60. Epub 1900 01 01.

Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes.

Pearson JP, Pesci EC, Iglewski BH

Journal of bacteriology.. 1997 September 179 (18):5756-67. Epub 1900 01 01.

Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.

Preston MJ, Seed PC, Toder DS, Iglewski BH, Ohman DE, Gustin JK, Goldberg JB, Pier GB

Infection and immunity.. 1997 August 65 (8):3086-90. Epub 1900 01 01.

Vfr controls quorum sensing in Pseudomonas aeruginosa.

Albus AM, Pesci EC, Runyen-Janecky LJ, West SE, Iglewski BH

Journal of bacteriology.. 1997 June 179 (12):3928-35. Epub 1900 01 01.

Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa.

Pesci EC, Pearson JP, Seed PC, Iglewski BH

Journal of bacteriology.. 1997 May 179 (10):3127-32. Epub 1900 01 01.

The chain of command in Pseudomonas quorum sensing.

Pesci EC, Iglewski BH

Trends in microbiology.. 1997 April 5 (4):132-4; discussion 134-5. Epub 1900 01 01.

Functional analysis of the Pseudomonas aeruginosa autoinducer PAI.

Passador L, Tucker KD, Guertin KR, Journet MP, Kende AS, Iglewski BH

Journal of bacteriology.. 1996 October 178 (20):5995-6000. Epub 1900 01 01.

Analysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region.

Rust L, Pesci EC, Iglewski BH

Journal of bacteriology.. 1996 February 178 (4):1134-40. Epub 1900 01 01.

Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection.

Tang HB, DiMango E, Bryan R, Gambello M, Iglewski BH, Goldberg JB, Prince A

Infection and immunity.. 1996 January 64 (1):37-43. Epub 1900 01 01.

A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.

Pearson JP, Passador L, Iglewski BH, Greenberg EP

Proceedings of the National Academy of Sciences of the United States of America.. 1995 February 2892 (5):1490-4. Epub 1900 01 01.

Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy.

Seed PC, Passador L, Iglewski BH

Journal of bacteriology.. 1995 February 177 (3):654-9. Epub 1900 01 01.

Interchangeability and specificity of components from the quorum-sensing regulatory systems of Vibrio fischeri and Pseudomonas aeruginosa.

Gray KM, Passador L, Iglewski BH, Greenberg EP

Journal of bacteriology.. 1994 May 176 (10):3076-80. Epub 1900 01 01.

lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity.

Toder DS, Ferrell SJ, Nezezon JL, Rust L, Iglewski BH

Infection and immunity.. 1994 April 62 (4):1320-7. Epub 1900 01 01.

Characterization of Pseudomonas aeruginosa mutants that are deficient in exotoxin A synthesis and are altered in expression of regA, a positive regulator of exotoxin A.

West SE, Kaye SA, Hamood AN, Iglewski BH

Infection and immunity.. 1994 March 62 (3):897-903. Epub 1900 01 01.

Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP

Proceedings of the National Academy of Sciences of the United States of America.. 1994 January 491 (1):197-201. Epub 1900 01 01.

Elastase assays.

Rust L, Messing CR, Iglewski BH

Methods in enzymology.. 1994 235 :554-62. Epub 1900 01 01.

Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication.

Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH

Science.. 1993 May 21260 (5111):1127-30. Epub 1900 01 01.

LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression.

Gambello MJ, Kaye S, Iglewski BH

Infection and immunity.. 1993 April 61 (4):1180-4. Epub 1900 01 01.

Structure-function analysis of exotoxin A proteins with mutations at histidine 426.

Wick MJ, Cook JM, Iglewski BH

Infection and immunity.. 1992 March 60 (3):1128-39. Epub 1900 01 01.

Isolation and characterization of toxin A excretion-deficient mutants of Pseudomonas aeruginosa PAO1.

Hamood AN, Ohman DE, West SE, Iglewski BH

Infection and immunity.. 1992 February 60 (2):510-7. Epub 1900 01 01.

Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa.

Frank DW, Iglewski BH

Journal of bacteriology.. 1991 October 173 (20):6460-8. Epub 1900 01 01.

Effect of regB on expression from the P1 and P2 promoters of the Pseudomonas aeruginosa regAB operon.

Storey DG, Raivio TL, Frank DW, Wick MJ, Kaye S, Iglewski BH

Journal of bacteriology.. 1991 October 173 (19):6088-94. Epub 1900 01 01.

Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR.

Toder DS, Gambello MJ, Iglewski BH

Molecular microbiology.. 1991 August 5 (8):2003-10. Epub 1900 01 01.

Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression.

Gambello MJ, Iglewski BH

Journal of bacteriology.. 1991 May 173 (9):3000-9. Epub 1900 01 01.

Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis.

Mohr CD, Rust L, Albus AM, Iglewski BH, Deretic V

Molecular microbiology.. 1990 December 4 (12):2103-10. Epub 1900 01 01.

Identification of functional epitopes of Pseudomonas aeruginosa exotoxin A using synthetic peptides and subclone products.

Olson JC, Hamood AN, Vincent TS, Beachey EH, Iglewski BH

Molecular immunology.. 1990 October 27 (10):981-93. Epub 1900 01 01.

Secretion of toxin A from Pseudomonas aeruginosa PAO1, PAK, and PA103 by Escherichia coli.

Hamood AN, Wick MJ, Iglewski BH

Infection and immunity.. 1990 May 58 (5):1133-40. Epub 1900 01 01.

Analysis of the structure-function relationship of Pseudomonas aeruginosa exotoxin A.

Wick MJ, Hamood AN, Iglewski BH

Molecular microbiology.. 1990 April 4 (4):527-35. Epub 1900 01 01.

Identification of regB, a gene required for optimal exotoxin A yields in Pseudomonas aeruginosa.

Wick MJ, Frank DW, Storey DG, Iglewski BH

Molecular microbiology.. 1990 March 4 (3):489-97. Epub 1900 01 01.

Multiple promoters control the regulation of the Pseudomonas aeruginosa regA gene.

Storey DG, Frank DW, Farinha MA, Kropinski AM, Iglewski BH

Molecular microbiology.. 1990 March 4 (3):499-503. Epub 1900 01 01.

Expression of the Pseudomonas aeruginosa toxA positive regulatory gene (regA) in Escherichia coli.

Hamood AN, Iglewski BH

Journal of bacteriology.. 1990 February 172 (2):589-94. Epub 1900 01 01.

Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A.

Wick MJ, Frank DW, Storey DG, Iglewski BH

Annual review of microbiology.. 1990 44 :335-63. Epub 1900 01 01.

Transformation of Pseudomonas aeruginosa by electroporation.

Smith AW, Iglewski BH

Nucleic acids research.. 1989 December 2517 (24):10509. Epub 1900 01 01.

Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa.

Frank DW, Storey DG, Hindahl MS, Iglewski BH

Journal of bacteriology.. 1989 October 171 (10):5304-13. Epub 1900 01 01.

Identification of RegA protein from Pseudomonas aeruginosa using anti-RegA antibody.

Zimniak L, Dayn A, Iglewski BH

Biochemical and biophysical research communications.. 1989 September 29163 (3):1312-8. Epub 1900 01 01.

Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S.

Coburn J, Wyatt RT, Iglewski BH, Gill DM

The Journal of biological chemistry.. 1989 May 25264 (15):9004-8. Epub 1900 01 01.

Regions of toxin A involved in toxin A excretion in Pseudomonas aeruginosa.

Hamood AN, Olson JC, Vincent TS, Iglewski BH

Journal of bacteriology.. 1989 April 171 (4):1817-24. Epub 1900 01 01.

Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin.

Coburn J, Dillon ST, Iglewski BH, Gill DM

Infection and immunity.. 1989 March 57 (3):996-8. Epub 1900 01 01.

Determination of the amino acid change responsible for the nontoxic, cross-reactive exotoxin A protein (CRM 66) of Pseudomonas aeruginosa PAO-PR1.

Wick MJ, Iglewski BH

Journal of bacteriology.. 1988 November 170 (11):5385-8. Epub 1900 01 01.

Codon usage in Pseudomonas aeruginosa.

West SE, Iglewski BH

Nucleic acids research.. 1988 October 1116 (19):9323-35. Epub 1900 01 01.

Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa.

Frank DW, Iglewski BH

Journal of bacteriology.. 1988 October 170 (10):4477-83. Epub 1900 01 01.

Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene.

Bever RA, Iglewski BH

Journal of bacteriology.. 1988 September 170 (9):4309-14. Epub 1900 01 01.

Characterization of a gene that regulates toxin A synthesis in Pseudomonas aeruginosa.

Hindahl MS, Frank DW, Hamood A, Iglewski BH

Nucleic acids research.. 1988 June 2416 (12):5699. Epub 1900 01 01.

Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene.

Schad PA, Iglewski BH

Journal of bacteriology.. 1988 June 170 (6):2784-9. Epub 1900 01 01.

Cloning and characterization of elastase genes from Pseudomonas aeruginosa.

Schad PA, Bever RA, Nicas TI, Leduc F, Hanne LF, Iglewski BH

Journal of bacteriology.. 1987 June 169 (6):2691-6. Epub 1900 01 01.

Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink.

Elsheikh LE, Kronevi T, Wretlind B, Abaas S, Iglewski BH

Veterinary microbiology.. 1987 March 13 (3):281-9. Epub 1900 01 01.

Cloning and expression of a common Legionella outer membrane antigen in Escherichia coli.

Hindahl MS, Iglewski BH

Microbial pathogenesis.. 1987 February 2 (2):91-9. Epub 1900 01 01.

Molecular studies of a positive regulator of toxin A synthesis in Pseudomonas aeruginosa.

Hindahl MS, Frank DW, Iglewski BH

Antibiotics and chemotherapy.. 1987 39 :279-89. Epub 1900 01 01.

The antigenicity of a pulmonary pathogen defined by monoclonal T cells.

Parmely MJ, Horvat RT, Iglewski BH, Kanarek J, Furtado D, Van Enk R

Advances in experimental medicine and biology.. 1987 216B :1043-51. Epub 1900 01 01.

Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F.

Woodruff WA, Parr TR, Hancock RE, Hanne LF, Nicas TI, Iglewski BH

Journal of bacteriology.. 1986 August 167 (2):473-9. Epub 1900 01 01.

Production of elastase and other exoproducts by environmental isolates of Pseudomonas aeruginosa.

Nicas TI, Iglewski BH

Journal of clinical microbiology.. 1986 May 23 (5):967-9. Epub 1900 01 01.

Purification and characterization of an extracellular protease of Legionella pneumophila.

Dreyfus LA, Iglewski BH

Infection and immunity.. 1986 March 51 (3):736-43. Epub 1900 01 01.

Outer membrane proteins from Legionella pneumophila serogroups and other Legionella species.

Hindahl MS, Iglewski BH

Infection and immunity.. 1986 January 51 (1):94-101. Epub 1900 01 01.

The role of exoenzyme S in infections with Pseudomonas aeruginosa.

Nicas TI, Bradley J, Lochner JE, Iglewski BH

The Journal of infectious diseases.. 1985 October 152 (4):716-21. Epub 1900 01 01.

Genetic mapping and characterization of Pseudomonas aeruginosa mutants that hyperproduce exoproteins.

Björklind A, Wretlind B, Möllegård I, Schad PA, Iglewski BH, Cox CD

Journal of bacteriology.. 1985 June 162 (3):1329-31. Epub 1900 01 01.

The contribution of exoproducts to virulence of Pseudomonas aeruginosa.

Nicas TI, Iglewski BH

Canadian journal of microbiology.. 1985 April 31 (4):387-92. Epub 1900 01 01.

Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections.

Nicas TI, Frank DW, Stenzel P, Lile JD, Iglewski BH

European journal of clinical microbiology.. 1985 April 4 (2):175-9. Epub 1900 01 01.

Defective triggering of polymorphonuclear leukocyte oxidative metabolism by Legionella pneumophila toxin.

Lochner JE, Bigley RH, Iglewski BH

The Journal of infectious diseases.. 1985 January 151 (1):42-6. Epub 1900 01 01.

Conjugation-mediated genetic exchange in Legionella pneumophila.

Dreyfus LA, Iglewski BH

Journal of bacteriology.. 1985 January 161 (1):80-4. Epub 1900 01 01.

Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.

Nicas TI, Iglewski BH

Antibiotics and chemotherapy.. 1985 36 :40-8. Epub 1900 01 01.

Genetic approaches to study Pseudomonas aeruginosa protein antigens.

Nicas TI, Iglewski BH

Advances in experimental medicine and biology.. 1985 185 :223-32. Epub 1900 01 01.

Identification of the principal T lymphocyte-stimulating antigens of Pseudomonas aeruginosa.

Parmely MJ, Iglewski BH, Horvat RT

The Journal of experimental medicine.. 1984 November 1160 (5):1338-49. Epub 1900 01 01.

Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S.

Nicas TI, Iglewski BH

Infection and immunity.. 1984 August 45 (2):470-4. Epub 1900 01 01.

Isolation and characterization of the Legionella pneumophila outer membrane.

Hindahl MS, Iglewski BH

Journal of bacteriology.. 1984 July 159 (1):107-13. Epub 1900 01 01.

Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model.

Howe TR, Iglewski BH

Infection and immunity.. 1984 March 43 (3):1058-63. Epub 1900 01 01.

Comparison of two methods of genetic exchange in determination of the genetic locus of the structural gene for Pseudomonas aeruginosa elastase.

Howe TR, Wretlind B, Iglewski BH

Journal of bacteriology.. 1983 October 156 (1):58-61. Epub 1900 01 01.

Locus of the Pseudomonas aeruginosa toxin A gene.

Hanne LF, Howe TR, Iglewski BH

Journal of bacteriology.. 1983 April 154 (1):383-6. Epub 1900 01 01.

Effect of oxygen-dependent antimicrobial systems on Legionella pneumophila.

Lochner JE, Friedman RL, Bigley RH, Iglewski BH

Infection and immunity.. 1983 January 39 (1):487-9. Epub 1900 01 01.

Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection.

Blackwood LL, Stone RM, Iglewski BH, Pennington JE

Infection and immunity.. 1983 January 39 (1):198-201. Epub 1900 01 01.

Toxins of Pseudomonas aeruginosa: new perspectives.

Woods DE, Iglewski BH

Reviews of infectious diseases.. 1983 5 Suppl 4 :S715-22. Epub 1900 01 01.

Toxoids of Pseudomonas aeruginosa toxin A: production by chemical and genetic means.

Cryz SJ, Iglewski BH

Reviews of infectious diseases.. 1983 5 Suppl 5 :S992-7. Epub 1900 01 01.

The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes.

Friedman RL, Lochner JE, Bigley RH, Iglewski BH

The Journal of infectious diseases.. 1982 September 146 (3):328-34. Epub 1900 01 01.

Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields.

Sokol PA, Cox CD, Iglewski BH

Journal of bacteriology.. 1982 August 151 (2):783-7. Epub 1900 01 01.

Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin.

Sadoff JC, Buck GA, Iglewski BH, Bjorn MJ, Groman NB

Infection and immunity.. 1982 July 37 (1):250-4. Epub 1900 01 01.

Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.

Woods DE, Cryz SJ, Friedman RL, Iglewski BH

Infection and immunity.. 1982 June 36 (3):1223-8. Epub 1900 01 01.

Modulatory effect of iron on the pathogenesis of Pseudomonas aeruginosa mouse corneal infections.

Woods DE, Sokol PA, Iglewski BH

Infection and immunity.. 1982 February 35 (2):461-4. Epub 1900 01 01.

Suppression of cytotoxicity of diphtheria toxin by monoclonal antibodies against phosphatidylinositol phosphate.

Friedman RL, Iglewski BH, Roerdink F, Alving CR

Biophysical journal.. 1982 January 37 (1):23-4. Epub 1900 01 01.

Experimental Pseudomonas exotoxin A mediated ocular damage in mouse pups: microscopic observations.

Hazlett LD, Iglewski BH, Berk RS

Ophthalmic research.. 1982 14 (6):401-8. Epub 1900 01 01.

Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A.

Hazlett LD, Berk RS, Iglewski BH

Infection and immunity.. 1981 December 34 (3):1025-35. Epub 1900 01 01.

Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa.

Sokol PA, Iglewski BH, Hager TA, Sadoff JC, Cross AS, McManus A, Farber BF, Iglewski WJ

Infection and immunity.. 1981 October 34 (1):147-53. Epub 1900 01 01.

In vitro production of an extracellular protease by Legionella pneumophila.

Thompson MR, Miller RD, Iglewski BH

Infection and immunity.. 1981 October 34 (1):299-302. Epub 1900 01 01.

Age-related susceptibility of mice to ocular challenge with Pseudomonas aeruginosa exotoxin A.

Berk RS, Iglewski BH, Hazlett LD

Infection and immunity.. 1981 July 33 (1):90-4. Epub 1900 01 01.

Effect of formalin toxoiding on Pseudomonas aeruginosa toxin A: biological, chemical, and immunochemical studies.

Cryz SJ, Friedman RL, Pavlovskis OR, Iglewski BH

Infection and immunity.. 1981 May 32 (2):759-68. Epub 1900 01 01.

Isolation and characterization of a Pseudomonas aeruginosa mutant producing a nontoxic, immunologically crossreactive toxin A protein.

Cryz SJ, Friedman RL, Iglewski BH

Proceedings of the National Academy of Sciences of the United States of America.. 1980 December 77 (12):7199-203. Epub 1900 01 01.

Evidence for the role of toxin A in the pathogenesis of infection with Pseudomonas aeruginosa in humans.

Cross AS, Sadoff JC, Iglewski BH, Sokol PA

The Journal of infectious diseases.. 1980 October 142 (4):538-46. Epub 1900 01 01.

Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa.

Ohman DE, Burns RP, Iglewski BH

The Journal of infectious diseases.. 1980 October 142 (4):547-55. Epub 1900 01 01.

Production of alkaline protease by Pseudomonas aeruginosa.

Cryz SJ, Iglewski BH

Journal of clinical microbiology.. 1980 July 12 (1):131-3. Epub 1900 01 01.

Identification of a cytotoxin produced by Legionella pneumophila.

Friedman RL, Iglewski BH, Miller RD

Infection and immunity.. 1980 July 29 (1):271-4. Epub 1900 01 01.

Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase.

Ohman DE, Cryz SJ, Iglewski BH

Journal of bacteriology.. 1980 June 142 (3):836-42. Epub 1900 01 01.

Toxin A-deficient mutants of Pseudomonas aeruginosa PA103: isolation and characterization.

Ohman DE, Sadoff JC, Iglewski BH

Infection and immunity.. 1980 June 28 (3):899-908. Epub 1900 01 01.

Binding of diphtheria toxin to phospholipids in liposomes.

Alving CR, Iglewski BH, Urban KA, Moss J, Richards RL, Sadoff JC

Proceedings of the National Academy of Sciences of the United States of America.. 1980 April 77 (4):1986-90. Epub 1900 01 01.

Effects of pseudomonas toxin A, diphtheria toxin, and cholera toxin on electrical characteristics of turtle bladder.

Brodsky WA, Sadoff JC, Durham JH, Ehrenspeck G, Schachner M, Iglewski BH

Proceedings of the National Academy of Sciences of the United States of America.. 1979 July 76 (7):3562-6. Epub 1900 01 01.

Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice.

Bjorn MJ, Pavlovskis OR, Thompson MR, Iglewski BH

Infection and immunity.. 1979 June 24 (3):837-42. Epub 1900 01 01.

Influence of iron on yields of extracellular products in Pseudomonas aeruginosa cultures.

Bjorn MJ, Sokol PA, Iglewski BH

Journal of bacteriology.. 1979 April 138 (1):193-200. Epub 1900 01 01.

A more sensitive plate assay for detection of protease production by Pseudomanas aeruginosa.

Sokol PA, Ohman DE, Iglewski BH

Journal of clinical microbiology.. 1979 April 9 (4):538-40. Epub 1900 01 01.

Toxin inhibitors of protein synthesis: production, purification, and assay of Pseudomonas aeruginosa toxin A.

Iglewski BH, Sadoff JC

Methods in enzymology.. 1979 60 :780-93. Epub 1900 01 01.

Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors.

Vasil ML, Iglewski BH

Journal of general microbiology.. 1978 October 108 (2):333-7. Epub 1900 01 01.

Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.

Iglewski BH, Sadoff J, Bjorn MJ, Maxwell ES

Proceedings of the National Academy of Sciences of the United States of America.. 1978 July 75 (7):3211-5. Epub 1900 01 01.

Effect of iron on yields of exotoxin A in cultures of Pseudomonas aeruginosa PA-103.

Bjorn MJ, Iglewski BH, Ives SK, Sadoff JC, Vasil ML

Infection and immunity.. 1978 March 19 (3):785-91. Epub 1900 01 01.

Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2.

Pavlovskis OR, Iglewski BH, Pollack M

Infection and immunity.. 1978 January 19 (1):29-33. Epub 1900 01 01.

Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infections.

Pavlovskis OR, Pollack M, Callahan LT, Iglewski BH

Infection and immunity.. 1977 December 18 (3):596-602. Epub 1900 01 01.

Incidence of exotoxin production by Pseudomonas species.

Bjorn MJ, Vasil ML, Sadoff JC, Iglewski BH

Infection and immunity.. 1977 April 16 (1):362-6. Epub 1900 01 01.

Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa.

Vasil ML, Kabat D, Iglewski BH

Infection and immunity.. 1977 April 16 (1):353-61. Epub 1900 01 01.

Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo.

Iglewski BH, Liu PV, Kabat D

Infection and immunity.. 1977 January 15 (1):138-44. Epub 1900 01 01.

Pathogenesis of corneal damage from pseudomonas exotoxin A.

Iglewski BH, Burns RP, Gipson IK

Investigative ophthalmology & visual science.. 1977 January 16 (1):73-6. Epub 1900 01 01.

Inhibition of Neisseria gonorrhoeae by a bacteriocin from Pseudomonas aeruginosa.

Morse SA, Vaughan P, Johnson D, Iglewski BH

Antimicrobial agents and chemotherapy.. 1976 August 10 (2):354-62. Epub 1900 01 01.

Antigenic relationships on the diphtheria toxin molecule: antitoxin versus antitoxoid.

Rittenberg MB, Pinney CT, Iglewski BH

Infection and immunity.. 1976 July 14 (1):122-8. Epub 1900 01 01.

Temperature-dependent inactivating factor of Pseudomonas aeruginosa exotoxin A.

Vasil ML, Liu PV, Iglewski BH

Infection and immunity.. 1976 May 13 (5):1467-72. Epub 1900 01 01.

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.

Iglewski BH, Kabat D

Proceedings of the National Academy of Sciences of the United States of America.. 1975 June 72 (6):2284-8. Epub 1900 01 01.

Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin.

Iglewski BH, Rittenberg MB, Iglewski WJ

Virology.. 1975 May 65 (1):272-5. Epub 1900 01 01.

Selective toxicity of diphtheria toxin for malignant cells.

Iglewski BH, Rittenberg MB

Proceedings of the National Academy of Sciences of the United States of America.. 1974 July 71 (7):2707-10. Epub 1900 01 01.

Synthesis of diphtheria toxin in E. coli cell-free lysate.

Lightfoot HN, Iglewski BH

Biochemical and biophysical research communications.. 1974 January 2356 (2):351-7. Epub 1900 01 01.

Diphtheria toxin: evidence for presence of fragment B in corynebacteriophage.

Elwell LP, Iglewski BH

Biochemical and biophysical research communications.. 1972 November 149 (3):609-14. Epub 1900 01 01.