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Kate G. Ackerman, M.D., M.B.A.

Kate G. Ackerman, M.D., M.B.A.

Pediatrics, Pediatric Critical Care

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About Me

Senior Vice Chair, Innovation & Integration, Pediatrics
Director of Pediatric Sedation, Golisano Children's Hospital
Chief Sedation Officer, Golisano Children's Hospital

Credentials

Residency & Fellowship

Fellowship, Pediatric Critical Care Medicine, Boston Children's Hospital (USA). 1998 - 2001

Residency, Resident, Children's Hospital Colorado. 1996 - 1998

Internship, Pediatrics, Children's Hospital Colorado. 1995 - 1996

Education

MD | SUNY at Buffalo-School of Medicine & Biomedical Sciences (USA). 1995

Awards

Laboratory awarded for best poster/project. 2013

Laboratory awarded for best poster/project. 2012

Laboratory awarded for best poster/project. 2011

Henry C. and Bertha H. Buswell Fellow. 2008 - 2009

Harvard Medical School Leadership Development for Physicians and Scientists. 2006

Children's Hospital Faculty Development Award/Eleanor and Miles Shore Scholar. 2005

Children's Hospital Fellow Research Award. 2002

Glascow Award. 1995

Association of Pathology Chairs Honor Society. 1995

Honors and Distinction in Research. 1995

Thesis Honors. 1995

Alpha Omega Alpha Honor Medical Society. 1994

Honors Poster Award. 1992

Dean's Letters of Commendation. 1991 - 1995

Research

Congenital Diaphragmatic Hernia (CDH) is a relatively common birth defect that results in a high rate of neonatal illness or death. The focus of Dr. Ackerman's laboratory is to identify genes that are necessary for development of the diaphragm and the lung.
Current research projects include:
...
Congenital Diaphragmatic Hernia (CDH) is a relatively common birth defect that results in a high rate of neonatal illness or death. The focus of Dr. Ackerman's laboratory is to identify genes that are necessary for development of the diaphragm and the lung.
Current research projects include:

- To identify mechanisms and pathway genes in Fog2 mediated diaphragm development and Fog2 mediated pulmonary lobar branching

-To investigate mechanisms of development in Barx1 homeobox gene associated posterior medical diaphragmatic hernia.

_To develop models for conditional deletion of genes on mesenchymal tissue of the diaphragm

-To develop new models of abnormal diaphragm and lung development from forward genetic screening

-To characterize human diaphragmatic defects and translate findings in animal models to the human disease with the hopes of modulating outcome in fetuses and neonates with congenital diaphragmatic defects

Publications

Journal Articles

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.

Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D'Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP, , Balachandran N, Murray TS, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin SE, Perella D, Jones K, Marohn KL, Yager PH, Fernandes ND, Flori HR, Koncicki ML, Walker KS, Di Pentima MC, Li S, Horwitz SM, Gaur S, Coffey DC, Harwayne-Gidansky I, Hymes SR, Thomas NJ, Ackerman KG, Cholette JM

JAMA network open.. 2021 June 14 (6):e2116420. Epub 06/01/2021.

Perspectives from the Society for Pediatric Research: advice on sustaining science and mentoring during COVID-19.

Forster CS, Nguyen ST, Powell WT, Moore DJ, Ho J, Heyman MB, Wenger TL, Gonzalez F, Hostetter M, Nowalk A, Rassbach CE, Boyer D, Weiss P, Blankenburg RL, Orange JS, Ackerman KG, Burns AM,

Pediatric research.. 2021 January 19 Epub 01/19/2021.

Fixing the leaky pipeline: identifying solutions for improving pediatrician-scientist training during pediatric residency.

Burns AM, Ackerman KG, Thammasitboon S, Rassbach CE, Ward MA, Blankenburg RL, Forster CS, McPhillips HA, Wenger TL, Powell WT, Heyman MB, Hogarty MD, Boyer D, Hostetter M, Weiss P, Nguyen ST, Parsons DW, Moore DJ, Byrne BJ, French AR, Orange JS

Pediatric research.. 2020 March 16 Epub 03/16/2020.

Siblings with lethal primary pulmonary hypoplasia and compound heterozygous variants in the gene: further delineation of the phenotypic spectrum.

Kiraly-Borri C, Jevon G, Ji W, Jeffries L, Ricciardi JL, Konstantino M, Ackerman KG, Lakhani SA

Cold Spring Harbor molecular case studies.. 2019 June 5 (3)Epub 06/03/2019.

Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children with Influenza-Related Critical Illness.

Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS, Shein SL, Moffitt K,

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2018 June 9 Epub 06/09/2018.

Congenital diaphragmatic hernias: from genes to mechanisms to therapies.

Kardon G, Ackerman KG, McCulley DJ, Shen Y, Wynn J, Shang L, Bogenschutz E, Sun X, Chung WK

Disease models & mechanisms.. 2017 August 110 (8):955-970. Epub 1900 01 01.

Congenital Diaphragmatic Hernia with Liver Herniation into the Pericardial Sac in a 30-Week Gestation Infant.

Patel N, Sollinger C, D'Angio CT, Vinocur JM, Ackerman KG, Katzman PJ

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2017 20 (5):421-425. Epub 01/25/2017.

Staphylococcus aureus ?-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.

Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS, Hall MW, Bubeck Wardenburg J, ,

The Journal of infectious diseases.. 2016 December 1214 (11):1638-1646. Epub 09/20/2016.

Case Report: Congenital diaphragmatic hernia with liver herniation into the pericardium in a 30-week gestation infant.

Patel N, Sollinger C, D'Angio CT, Vinocur JM, Ackerman KG, Katzman PJ

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2016 March 28 Epub 03/28/2016.

Dissatisfaction with maintenance of certification in academic pediatrics.

Ackerman KG, Lee B, Kushner JA

Pediatric research.. 2016 February 79 (2):240-2. Epub 09/30/2015.

Wt1 and ?-catenin cooperatively regulate diaphragm development in the mouse.

Paris ND, Coles GL, Ackerman KG

Developmental biology.. 2015 November 1407 (1):40-56. Epub 08/14/2015.

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.

Coles GL, Baglia LA, Ackerman KG

PLoS genetics.. 2015 October 11 (10):e1005525. Epub 10/06/2015.

Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia.

Longoni M, Russell MK, High FA, Darvishi K, Maalouf FI, Kashani A, Tracy AA, Coletti CM, Loscertales M, Lage K, Ackerman KG, Woods SA, Ward-Melver C, Andrews D, Lee C, Pober BR, Donahoe PK

Clinical genetics.. 2015 April 87 (4):362-7. Epub 04/26/2014.

Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics.

Longoni M, High FA, Russell MK, Kashani A, Tracy AA, Coletti CM, Hila R, Shamia A, Wells J, Ackerman KG, Wilson JM, Bult CJ, Lee C, Lage K, Pober BR, Donahoe PK

Proceedings of the National Academy of Sciences of the United States of America.. 2014 August 26111 (34):12450-5. Epub 08/08/2014.

Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

Coles GL, Ackerman KG

Proceedings of the National Academy of Sciences of the United States of America.. 2013 May 21110 (21):E1898-905. Epub 05/06/2013.

Innate immune function and mortality in critically ill children with influenza: a multicenter study.

Hall MW, Geyer SM, Guo CY, Panoskaltsis-Mortari A, Jouvet P, Ferdinands J, Shay DK, Nateri J, Greathouse K, Sullivan R, Tran T, Keisling S, Randolph AG,

Critical care medicine.. 2013 January 41 (1):224-36. Epub 1900 01 01.

Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.

Russell MK, Longoni M, Wells J, Maalouf FI, Tracy AA, Loscertales M, Ackerman KG, Pober BR, Lage K, Bult CJ, Donahoe PK

Proceedings of the National Academy of Sciences of the United States of America.. 2012 February 21109 (8):2978-83. Epub 02/06/2012.

Congenital diaphragmatic defects: proposal for a new classification based on observations in 234 patients.

Ackerman KG, Vargas SO, Wilson JM, Jennings RW, Kozakewich HP, Pober B

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2012 15 (4):265-74. Epub 03/07/2012.

The Naïve Airway Hyperresponsiveness of the A/J Mouse is Kit-Mediated.

Cozzi E, Ackerman KG, Lundequist A, Drazen J, Boyce J, Beier DR.

Proc Natl Acad Sci USA. 2011; 108(31): 12787-92.

Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH.

Kantarci S, Ackerman KG, Russell MK, Longoni M, Sougnez C, Noonan KM, Hatchwell E, Zhang X, Pieretti Vanmarcke R, Anyane-Yeboa K, Dickman P, Wilson J, Donahoe PK, Pober BR

American journal of medical genetics. Part A.. 2010 October 152A (10):2493-504. Epub 1900 01 01.

Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.

Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT

The Journal of clinical investigation.. 2009 June 119 (6):1462-76. Epub 1900 01 01.

Timing of delivery and survival rates for infants with prenatal diagnoses of congenital diaphragmatic hernia.

Stevens TP, van Wijngaarden E, Ackerman KG, Lally PA, Lally KP,

Pediatrics.. 2009 February 123 (2):494-502. Epub 1900 01 01.

Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.

Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA

Circulation.. 2009 January 20119 (2):261-8. Epub 12/31/2008.

Gata4 is necessary for normal pulmonary lobar development.

Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR

American journal of respiratory cell and molecular biology.. 2007 April 36 (4):391-7. Epub 12/01/2006.

Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program.

Pober BR, Lin A, Russell M, Ackerman KG, Chakravorty S, Strauss B, Westgate MN, Wilson J, Donahoe PK, Holmes LB

American journal of medical genetics. Part A.. 2005 October 1138A (2):81-8. Epub 1900 01 01.

Fog2 is required for normal diaphragm and lung development in mice and humans.

Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR

PLoS genetics.. 2005 July 1 (1):58-65. Epub 06/17/2005.

Interacting genetic loci cause airway hyperresponsiveness.

Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR

Physiological genomics.. 2005 March 2121 (1):105-11. Epub 01/18/2005.

Lipoxins and aspirin-triggered lipoxins in airway responses.

Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt B, Szczeklik W, Drazen JM, Serhan CN

Advances in experimental medicine and biology.. 2003 525 :19-23. Epub 1900 01 01.

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).

Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN

Nature medicine.. 2002 September 8 (9):1018-23. Epub 08/12/2002.

Cardiorespiratory arrest.

Ackerman K, Creery D

Clinical evidence. 2002 June (7):283-91. Epub 1900 01 01.

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.

Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH

Science.. 2002 January 11295 (5553):336-8. Epub 1900 01 01.

CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness.

MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FH, Charo IF, Luster AD

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 December 1165 (11):6568-75. Epub 1900 01 01.

Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term.

Grover TR, Ackerman KG, Le Cras TD, Jobe AH, Abman SH

Pediatric research.. 2000 July 48 (1):75-83. Epub 1900 01 01.

Cystic periventricular leukomalacia and type of cerebral palsy in preterm infants.

Rogers B, Msall M, Owens T, Guernsey K, Brody A, Buck G, Hudak M

The Journal of pediatrics.. 1994 July 125 (1):S1-8. Epub 1900 01 01.

Books

Principles of Developmental Genetics (2013)

Chapter: Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects.

Authors: Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects

Publisher: Elsevier Inc., Burlington, MA 2013

Principles of Developmental Genetics (2007)

Chapter: Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects.

Authors: Ackerman, KG and Beier DR.

Publisher: Elsevier Inc., Philadelphia, PA 2007