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Brian Poligone, M.D., Ph.D.

Brian Poligone, M.D., Ph.D.

Specialties

Dermatology

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Contact

Appointment (585) 487-1400

About Me

Dr. Poligone is an Assistant Professor in the Department of Dermatology at the University of Rochester. He completed his Dermatology training at Yale University, where he developed a special interest in cutaneous lymphoma. He is a member of the Wilmot Cancer Center.

Dr. Poligone directs the ...
Dr. Poligone is an Assistant Professor in the Department of Dermatology at the University of Rochester. He completed his Dermatology training at Yale University, where he developed a special interest in cutaneous lymphoma. He is a member of the Wilmot Cancer Center.

Dr. Poligone directs the Cutaneous Lymphoma clinic at the University of Rochester, which offers an integrated approach to the treatment of all skin lymphomas. This allows for the full evaluation, consultation, and management of B and T cell lymphomas. Current therapies include topical and biologic therapies, infusional and systemic therapies, phototherapy, radiation therapy, photopheresis, and multiple clinical trials for refractory disease.

Certified Specialties

Dermatology - American Board of Dermatology

Credentials

Residency & Fellowship

Fellowship, Dermatology, Yale New Haven Medical Center. 2006 - 2008

Residency, Dermatology, Yale New Haven Medical Center. 2004 - 2007

Internship, Internal Medicine, Stanford University Medical Center. 2003 - 2004

Education

MD | University of North Carolina at Chapel Hill. 2003

Awards

Dermatology Foundation Career Development Award. 2008

www.facultyof1000.com, Journal of Immunology. 2002

American Society of Hematology, Medical Student Fellowship. 1999

National Institutes of Health Summer Research Fellowship. 1999 - 1999

John B. Graham Research Society. 1999

Evaluation of a Hereditary Thrombocytopenia in a Family in Coastal North Carolina. 1998 - 1999

Class of 1938 Scholar (Summer Study). 1994

Harrisburg Physicians Scholarship. 1994

Howard Hughes Undergraduate Research Grant. 1993

Eta Sigma Phi (National Classical Studies Honor Society). 1992

Medical Scientist Training Program (Eight Years Scholarship). 1988 - 1996

Dean's List and Honors in Biology (All Semesters).

Research

The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind ski...
The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind skin inflammation and carcinogenesis. By studying animal models of disease, we are better able to translate our findings into clinically relevant treatments for human disease. Through his past work with Drs. Albert S. Baldwin and Sankar Ghosh, Dr. Poligone has gained expertise in the study of NF kappa B and has focused his attention to the skin. Currently we are examining how NF kappa B is involved in the formation of a type of skin cancer called a keratoacanthoma. Dr. Poligone has also examined the role of NF kappa B in psoriasis and specifically has been examining NF kappa B inhibitors in this disease.

Publications

Journal Articles

A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells.

Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J

Immunology letters.. 2016 April 172 :67-78. Epub 02/26/2016.

Cutaneous T cell Lymphoma: an Update on Pathogenesis and Systemic Therapy.

Chung CG, Poligone B

Current hematologic malignancy reports.. 2015 December 10 (4):468-76. Epub 1900 01 01.

Management of advanced cutaneous T-cell lymphoma: role of the dermatologist in the multidisciplinary team.

Poligone B, Querfeld C

The British journal of dermatology.. 2015 October 173 (4):1081-3. Epub 08/27/2015.

Other Chemotherapeutic Agents in Cutaneous T-Cell Lymphoma.

Chung CG, Poligone B

Dermatologic clinics.. 2015 October 33 (4):787-805. Epub 08/18/2015.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J

Oncotarget.. 2015 June 20 :14796-14813. Epub 06/20/2015.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J

Oncotarget.. 2015 June 206 (17):14796-813. Epub 1900 01 01.

PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin.

Poligone B, Gilmore ES, Alexander C, Oleksyn D, Gillespie K, Zhao J, Ibrahim S, Pentland AP, Brown M, Chen L

The Journal of investigative dermatology.. 2015 March 135 (3):869-876. Epub 10/06/2014.

Risk of mortality in hydroa vacciniforme and hypersensitivity to mosquito bites.

Poligone B

The British journal of dermatology.. 2015 January 172 (1):5-6. Epub 1900 01 01.

The spectrum of pigmented purpuric dermatosis and mycosis fungoides: atypical T-cell dyscrasia.

Ladrigan MK, Poligone B

Cutis.. 2014 December 94 (6):297-300. Epub 1900 01 01.

The good, the bad, and the ugly of free drug samples.

Poligone B

JAMA dermatology.. 2014 November 150 (11):1237-8. Epub 1900 01 01.

A role for NF-?B activity in skin hyperplasia and the development of keratoacanthomata in mice.

Poligone B, Hayden MS, Chen L, Pentland AP, Jimi E, Ghosh S

PloS one.. 2013 8 (8):e71887. Epub 08/19/2013.

Pruritus in cutaneous T-cell lymphoma: a review.

Ahern K, Gilmore ES, Poligone B

Journal of the American Academy of Dermatology.. 2012 October 67 (4):760-8. Epub 01/30/2012.

Menus for managing patients with cutaneous T-cell lymphoma.

Poligone B, Heald P

Seminars in cutaneous medicine and surgery.. 2012 March 31 (1):25-32. Epub 1900 01 01.

Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma.

Poligone B, Lin J, Chung C

Core evidence.. 2011 6 :1-12. Epub 12/22/2010.

Innovative therapy of cutaneous T-cell lymphoma: beyond psoralen and ultraviolet light and nitrogen mustard.

Poligone B, Heald P

Dermatologic clinics.. 2010 July 28 (3):501-10. Epub 1900 01 01.

Primary cutaneous T-cell lymphoma localized to the lower leg: a distinct, locally aggressive cutaneous T-cell lymphoma.

Poligone B, Wilson LD, Subtil A, Heald P

Archives of dermatology.. 2009 June 145 (6):677-82. Epub 1900 01 01.

Primary cutaneous T-cell lymphoma localized to the lower leg. A distinct locally aggressive cutaneous T-cell lymphoma.

Poligone B, Wilson L, Subtil A, Heald P.

Archives of Dermatology. 2009; 145: 6.

A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution.

Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R.

Am J Dermatopathol. 2009; 31(1): 37-43.

Bazex Syndrome (Acrokeratosis Paraneoplastica).

Poligone, B, S. Christensen, R. Lazova, P. Heald.

The Lancet. 2007; 369: 530.

NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.

Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS Jr, Tisch R.

J Immunol. 2003; 170: 1770-80.

Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells Results in enhanced APC function.

Poligone, B., D.J. Weaver, Jr., P. Sen, A.S. Baldwin, Jr., and R. Tisch.

J Immunology. 2002; 168: 188-96.

Dysregulation of NF-?B signaling enhances the antigen presenting cell function of NOD mouse dendritic cells.

Poligone, B., D.J. Weaver, Jr., T. Bui, U.A. Motel, A.S. Baldwin, Jr., and R. Tisch.

Scandanavian J Immunology. 2001; 54: s1.

Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins.

Poligone, B., and A.S. Baldwin.

J Biological Chemistry. 2001; 276: 38658-64.

Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase.

Weaver, D.J., Jr., B. Poligone, T. Bui, U.M. Abdel-Motal, A.S. Baldwin, Jr., and R. Tisch.

J Immunology. 2001; 167: 1461-8.

Dendritic cell vaccination induces cross-reactive cytotoxic T lymphocytes specific for wild-type and natural variant human immunodeficiency virus type 1 epitopes in HLA-A*0201/Kb transgenic mice.

Abdel-Motal, U.M., R. Friedline, B. Poligone, R.R. Pogue-Caley, J.A. Frelinger, and R. Tisch.

Clinical Immunology. 2001; 101: 51-8.

Books

"Springtime Dermatology" (2007)

Authors: Poligone, B

Publisher: Cortlandt Forum 2007

"Spider Bites" (2007)

Authors: Poligone, B

Publisher: Cortlandt Forum 2007

"Seasonal Dermatoses" (2007)

Authors: Poligone, B

Publisher: Cortlandt Forum 2007

Manual of Dermatologic Therapeutics: With essentials of diagnosis (2006)

Chapter: Sexually transmitted diseases

Authors: Poligone B, Kulwichit W

Publisher: Lippincott, Williams & Wilkins 2006

"Cutaneous signs of other diseases" (2006)

Authors: Poligone, B

Publisher: Cortlandt Forum 2006

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