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Neil Lachant, M.D.

Neil Lachant, M.D.

Cancer

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 275-5823

About Me

Certified Specialties

Hematology - American Board of Internal Medicine

Internal Medicine - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Hematology/Oncology (SMD)

Credentials

Residency & Fellowship

Fellowship, SUNY Upstate University Hospital. 1979 - 1980

Residency, Hematology, SUNY Upstate University Hospital. 1977 - 1979

Residency, Internal Medicine, SUNY Upstate University Hospital. 1975 - 1977

Internship, Internal Medicine, SUNY Upstate University Hospital. 1974 - 1975

Education

MD | University of Vermont College of Medicine. 1974

Publications

Journal Articles

Duplication of chromosome 1 [dup(1)(q21q32)] as the sole cytogenetic abnormality in a patient previously treated for AML.

Beach DF, Barnoski BL, Aviv H, Patel V, Schwarting R, Strair R, Lachant NA

Cancer genetics.. 2012 December 205 (12):665-8. Epub 11/16/2012.

A sheep in wolf's clothing.

Dalsania CJ, Khemka V, Shum M, Devereux L, Lachant NA

The American journal of medicine.. 2008 February 121 (2):107-9. Epub 1900 01 01.

Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells.

Rengan R, Ochs HD, Sweet LI, Keil ML, Gunning WT, Lachant NA, Boxer LA, Omann GM

Blood.. 2000 February 1595 (4):1283-92. Epub 1900 01 01.

Physiologic concentrations of arginine vasopressin activate human platelets in vitro.

Wun T, Paglieroni T, Lachant NA

British journal of haematology.. 1996 March 92 (4):968-72. Epub 1900 01 01.

Desmopressin stimulates the expression of P-selectin on human platelets in vitro.

Wun T, Paglieroni TG, Lachant NA

The Journal of laboratory and clinical medicine.. 1995 October 126 (4):401-9. Epub 1900 01 01.

Heterogeneity of the aggregation response of human platelets to arginine vasopressin.

Lachant NA, Smith MR, Xie ZJ, Romani WR

American journal of hematology.. 1995 May 49 (1):56-66. Epub 1900 01 01.

Decreased pyrimidine nucleoside monophosphate kinase activity in sickle erythrocytes.

Lent KM, Lachant NA, Zerez CR, Tanaka KR

Blood.. 1992 July 1580 (2):512-6. Epub 1900 01 01.

Hereditary erythrocyte adenylate kinase deficiency: a defect of multiple phosphotransferases?

Lachant NA, Zerez CR, Barredo J, Lee DW, Savely SM, Tanaka KR

Blood.. 1991 June 1577 (12):2774-84. Epub 1900 01 01.

Dimethyl sulfoxide enhances hexose monophosphate shunt activity in cultured glomerular mesangial cells, leukocytes and erythrocytes.

Adler SG, Lachant NA, Anderson PS, Cohen AH, Davidson WD, Glassock RJ

Mineral and electrolyte metabolism.. 1991 17 (1):52-7. Epub 1900 01 01.

Impaired erythrocyte methemoglobin reduction in sickle cell disease: dependence of methemoglobin reduction on reduced nicotinamide adenine dinucleotide content.

Zerez CR, Lachant NA, Tanaka KR

Blood.. 1990 September 176 (5):1008-14. Epub 1900 01 01.

Bone marrow examination in patients with AIDS and AIDS-related complex (ARC). Morphologic and in situ hybridization studies.

Sun NC, Shapshak P, Lachant NA, Hsu MY, Sieger L, Schmid P, Beall G, Imagawa DT

American journal of clinical pathology.. 1989 November 92 (5):589-94. Epub 1900 01 01.

Decreased erythrocyte phosphoribosylpyrophosphate synthetase activity and impaired formation in thalassemia minor: a mechanism for decreased adenine nucleotide content.

Zerez CR, Lachant NA, Tanaka KR

The Journal of laboratory and clinical medicine.. 1989 July 114 (1):43-50. Epub 1900 01 01.

Relationship between the nicotinamide adenine dinucleotide redox potential and the 2,3-diphosphoglycerate content in the erythrocyte in sickle cell disease.

Lachant NA, Zerez CR, Tanaka KR

British journal of haematology.. 1989 June 72 (2):265-71. Epub 1900 01 01.

Pyrimidine nucleotides impair phosphoribosylpyrophosphate (PRPP) synthetase subunit aggregation by sequestering magnesium. A mechanism for the decreased PRPP synthetase activity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.

Lachant NA, Zerez CR, Tanaka KR

Biochimica et biophysica acta.. 1989 January 19994 (1):81-8. Epub 1900 01 01.

Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.

Zerez CR, Wong MD, Lachant NA, Tanaka KR

Blood.. 1988 August 72 (2):500-6. Epub 1900 01 01.

Decreased erythrocyte nicotinamide adenine dinucleotide redox potential and abnormal pyridine nucleotide content in sickle cell disease.

Zerez CR, Lachant NA, Lee SJ, Tanaka KR

Blood.. 1988 February 71 (2):512-5. Epub 1900 01 01.

Inhibitory effect of mannose on erythrocyte defense against oxidants.

Lachant NA, Zerez CR

Biochimica et biophysica acta.. 1988 January 12964 (1):96-104. Epub 1900 01 01.

Treatment of refractory lymphoma with methotrexate, VM-26 (teniposide), procarbazine, and dexamethasone: Cancer and Leukemia Group B study 7902.

Lachant NA, Anderson J, Ginsberg SJ, Cooper MR, Hurd DD, Bloomfield CD, Gottlieb AJ

Medical and pediatric oncology.. 1988 16 (6):375-7. Epub 1900 01 01.

Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait.

Lachant NA, Tanaka KR

The American journal of the medical sciences.. 1987 November 294 (5):364-8. Epub 1900 01 01.

Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?

Lachant NA, Tanaka KR

American journal of hematology.. 1987 November 26 (3):211-9. Epub 1900 01 01.

Vaso-occlusive crisis-associated neutrophil dysfunction in patients with sickle-cell disease.

Lachant NA, Oseas RS

The American journal of the medical sciences.. 1987 October 294 (4):253-7. Epub 1900 01 01.

Hemoglobin E: an emerging hemoglobinopathy in the United States.

Lachant NA

American journal of hematology.. 1987 August 25 (4):449-62. Epub 1900 01 01.

Pyrimidine nucleoside monophosphate kinase hyperactivity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.

Lachant NA, Zerez CR, Tanaka KR

British journal of haematology.. 1987 May 66 (1):91-6. Epub 1900 01 01.

Decrease in subunit aggregation of phosphoribosylpyrophosphate synthetase: a mechanism for decreased nucleotide concentrations in pyruvate kinase-deficient human erythrocytes.

Zerez CR, Lachant NA, Tanaka KR

Blood.. 1986 November 68 (5):1024-9. Epub 1900 01 01.

Red cell metabolism in hereditary pyrimidine 5'-nucleotidase deficiency: effect of magnesium.

Lachant NA, Tanaka KR

British journal of haematology.. 1986 August 63 (4):615-23. Epub 1900 01 01.

Antioxidants in sickle cell disease: the in vitro effects of ascorbic acid.

Lachant NA, Tanaka KR

The American journal of the medical sciences.. 1986 July 292 (1):3-10. Epub 1900 01 01.

Effect of triethyltin on enzyme activity in human adult and cord red cells.

Patritti-Laborde N, Lachant NA, Tomoda A, Chan MH, Tanaka KR

Enzyme.. 1986 35 (2):87-95. Epub 1900 01 01.

Increased Heinz body formation and impaired erythrocyte pentose phosphate shunt function during pregnancy.

Lachant NA, Gottlieb AJ, DiFino SM, Landaw SA, Tanaka KR

American journal of hematology.. 1985 February 18 (2):131-41. Epub 1900 01 01.

Multicentric angiofollicular lymph node hyperplasia (Castleman's disease) followed by Kaposi's sarcoma in two homosexual males with the acquired immunodeficiency syndrome (AIDS).

Lachant NA, Sun NC, Leong LA, Oseas RS, Prince HE

American journal of clinical pathology.. 1985 January 83 (1):27-33. Epub 1900 01 01.

Pyrimidine nucleotides do not affect the enzymes of glutathione biosynthesis.

Zerez CR, Lachant NA, Tanaka KR

Enzyme.. 1985 34 (2):94-7. Epub 1900 01 01.

Antioxidant metabolism during blood storage and its relationship to posttransfusion red cell survival.

Lachant NA, Noble NA, Myrhe BA, Tanaka KR

American journal of hematology.. 1984 October 17 (3):237-49. Epub 1900 01 01.

Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency. II. Effect of pyrimidine nucleotides and their derivatives on glycolytic and pentose phosphate shunt enzyme activity.

Oda E, Oda S, Tomoda A, Lachant NA, Tanaka KR

Clinica chimica acta; international journal of clinical chemistry.. 1984 August 31141 (2-3):93-100. Epub 1900 01 01.

Inhibition of the pentose phosphate shunt by lead: a potential mechanism for hemolysis in lead poisoning.

Lachant NA, Tomoda A, Tanaka KR

Blood.. 1984 March 63 (3):518-24. Epub 1900 01 01.

CDP-choline does not inhibit erythrocyte glycolytic or pentose phosphate pathway enzyme activity.

Lachant NA, Tanaka KR

Enzyme.. 1984 32 (4):228-31. Epub 1900 01 01.

Impaired pentose phosphate shunt function in sickle cell disease: a potential mechanism for increased Heinz body formation and membrane lipid peroxidation.

Lachant NA, Davidson WD, Tanaka KR

American journal of hematology.. 1983 August 15 (1):1-13. Epub 1900 01 01.

Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.

Tomoda A, Lachant NA, Noble NA, Tanaka KR

British journal of haematology.. 1983 July 54 (3):475-84. Epub 1900 01 01.

Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency: nucleotide inhibition of G6PD and the pentose phosphate shunt.

Tomoda A, Noble NA, Lachant NA, Tanaka KR

Blood.. 1982 November 60 (5):1212-8. Epub 1900 01 01.

HLA antigens and childhood acute lymphocytic leukaemia.

Davey FR, Lachant NA, Dock NL, Hubbell C, Stockman JA, Henry JB

British journal of haematology.. 1981 February 47 (2):211-20. Epub 1900 01 01.

Adult idiopathic thrombocytopenic purpura. Clinical findings and response to therapy.

DiFino SM, Lachant NA, Kirshner JJ, Gottlieb AJ

The American journal of medicine.. 1980 September 69 (3):430-42. Epub 1900 01 01.

Spontaneous remission in acute myelogenous leukemia in the adult.

Lachant NA, Goldberg J, Nelson DA, Gottlieb AJ

The American journal of medicine.. 1979 October 67 (4):687-92. Epub 1900 01 01.