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Bernard M. Ravina, M.D.

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About Me

Professional Background

Dr. Ravina is an Associate Professor of Neurology, the Director of the Movement and Inherited Neurological Disorders (MIND) Unit, and the Associate Director of the Clinical Trials Coordination Center (CTCC) at the University of Rochester School of Medicine and Dentistry. After obtaining his MD from ...
Dr. Ravina is an Associate Professor of Neurology, the Director of the Movement and Inherited Neurological Disorders (MIND) Unit, and the Associate Director of the Clinical Trials Coordination Center (CTCC) at the University of Rochester School of Medicine and Dentistry. After obtaining his MD from Johns Hopkins University, Dr. Ravina completed residency training in Neurology and a Fellowship in Parkinson's disease and Movement Disorders at the University of Pennsylvania. Additionally, Dr. Ravina completed a two year Masters in Clinical Epidemiology and Biostatistics program at the University of Pennsylvania Center for Clinical Epidemiology and Biostatistics. After training, Dr. Ravina spent four years at NINDS/NIH where he was responsible for an innovative program of phase II clinical trials in Parkinson's disease, as well as having oversight of clinical trials in stroke and ALS. Dr. Ravina is a PI or a member on the steering committee for several phase I, II and III clinical trials and chairs two independent DSMBs, including the NIA sponsored clinical trial of Rosiglitazone in Mild Cognitive Impairment. Dr. Ravina has become a recognized expert in clinical trials in movement disorders. He has published numerous articles and book chapters. Dr. Ravina has also lectured by invitation both nationally and world wide. He is an editorial board member of Clinical Neuropharmacology and a reviewer for the FDA Orphan Product Division. Dr. Ravina brings valuable perspectives from both the sponsor side at NIH and from academic medicine and collaborations with industry.

Faculty Appointments

Adjunct Professor - Department of Neurology, Center for Health and Technology (SMD)

Credentials

Post-doctoral Training & Residency

1995-1996 Intern in Internal Medicine, University of Pittsburgh Medical Center
1996-1999 Resident in Neurology, Hospital of the University of Pennsylvania
1999-2001 Post Doctoral Fellow, Parkinson's Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania

Education

Masters | University of Pennsylvania. Clinical Epidemiology. 2001

MD | Johns Hopkins U Sch Medicine. Medicine. 1995

BA | Columbia University. Psychology. 1989

Publications

Journal Articles

Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia.

Di Prospero NA, Sumner CJ, Penzak SR, Ravina B, Fischbeck KH, Taylor JP

Archives of neurology.. 2007 June 64 (6):803-8. Epub 1900 01 01.

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM

Neurology.. 2007 January 3068 (5):384-6. Epub 11/02/2006.

Biomarkers in Parkinson's disease.

Dorsey ER, Holloway RG, Ravina BM

Expert review of neurotherapeutics.. 2006 June 6 (6):823-31. Epub 1900 01 01.

Optimizing the ongoing search for new treatments for Parkinson disease: using futility designs.

Tilley BC, Palesch YY, Kieburtz K, Ravina B, Huang P, Elm JJ, Shannon K, Wooten GF, Tanner CM, Goetz GC,

Neurology.. 2006 March 1466 (5):628-33. Epub 1900 01 01.

Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group.

Marsh L, McDonald WM, Cummings J, Ravina B,

Movement disorders : official journal of the Movement Disorder Society.. 2006 February 21 (2):148-58. Epub 1900 01 01.

Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease.

Fujita M, Ichise M, Zoghbi SS, Liow JS, Ghose S, Vines DC, Sangare J, Lu JQ, Cropley VL, Iida H, Kim KM, Cohen RM, Bara-Jimenez W, Ravina B, Innis RB

Annals of neurology.. 2006 January 59 (1):174-7. Epub 1900 01 01.

Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study.

Ravina B, Putt M, Siderowf A, Farrar JT, Gillespie M, Crawley A, Fernandez HH, Trieschmann MM, Reichwein S, Simuni T

Journal of neurology, neurosurgery, and psychiatry.. 2005 July 76 (7):934-9. Epub 1900 01 01.

A responsive outcome for Parkinson's disease neuroprotection futility studies.

Elm JJ, Goetz CG, Ravina B, Shannon K, Wooten GF, Tanner CM, Palesch YY, Huang P, Guimaraes P, Kamp C, Tilley BC, Kieburtz K,

Annals of neurology.. 2005 February 57 (2):197-203. Epub 1900 01 01.

The role of radiotracer imaging in Parkinson disease.

Ravina B, Eidelberg D, Ahlskog JE, Albin RL, Brooks DJ, Carbon M, Dhawan V, Feigin A, Fahn S, Guttman M, Gwinn-Hardy K, McFarland H, Innis R, Katz RG, Kieburtz K, Kish SJ, Lange N, Langston JW, Marek K, Morin L, Moy C, Murphy D, Oertel WH, Oliver G, Palesch Y, Powers W, Seibyl J, Sethi KD, Shults CW, Sheehy P, Stoessl AJ, Holloway R

Neurology.. 2005 January 2564 (2):208-15. Epub 1900 01 01.

Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trials.

Guimaraes P, Kieburtz K, Goetz CG, Elm JJ, Palesch YY, Huang P, Ravina B, Tanner CM, Tilley BC

Clinical trials : journal of the Society for Clinical Trials.. 2005 2 (6):509-18. Epub 1900 01 01.

Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

Chou KL, Hurtig HI, Stern MB, Colcher A, Ravina B, Newberg A, Mozley PD, Siderowf A

Parkinsonism & related disorders.. 2004 August 10 (6):375-9. Epub 1900 01 01.

Funding evidence: the National Institute of Neurological Disorders and Stroke Clinical Trials Program.

Ravina B, Janis S, Keleti J, Marler JM

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics.. 2004 July 1 (3):317-22. Epub 1900 01 01.

Exercise-induced dystonia as a preceding symptom of familial Parkinson's disease.

Bruno MK, Ravina B, Garraux G, Hallett M, Ptacek L, Singleton A, Johnson J, Singleton A, Hanson M, Considine E, Gwinn-Hardy K

Movement disorders : official journal of the Movement Disorder Society.. 2004 February 19 (2):228-30. Epub 1900 01 01.

Slowing Parkinson's Disease: The Promise and Peril of Neuropretection Trials.

Ravina, B.;.

Practical Neurology. 2004; 3(6): 21-26.

Mutation at the SCA17 locus is not a common cause of parkinsonism.

Hernandez D, Hanson M, Singleton A, Gwinn-Hardy K, Freeman J, Ravina B, Doheny D, Gallardo M, Weiser R, Hardy J, Singleton A

Parkinsonism & related disorders.. 2003 August 9 (6):317-20. Epub 1900 01 01.

Brain banking for neurodegenerative diseases.

Murphy DD, Ravina B

Current opinion in neurology.. 2003 August 16 (4):459-63. Epub 1900 01 01.

Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation.

Hague S, Rogaeva E, Hernandez D, Gulick C, Singleton A, Hanson M, Johnson J, Weiser R, Gallardo M, Ravina B, Gwinn-Hardy K, Crawley A, St George-Hyslop PH, Lang AE, Heutink P, Bonifati V, Hardy J, Singleton A

Annals of neurology.. 2003 August 54 (2):271-4. Epub 1900 01 01.

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment.

Ravina BM, Fagan SC, Hart RG, Hovinga CA, Murphy DD, Dawson TM, Marler JR

Neurology.. 2003 April 2260 (8):1234-40. Epub 1900 01 01.

From chemical to drug: neurodegeneration drug screening and the ethics of clinical trials.

Heemskerk J, Tobin AJ, Ravina B

Nature neuroscience.. 2002 November 5 Suppl :1027-9. Epub 1900 01 01.

Preference-based quality-of-life in patients with Parkinson's disease.

Siderowf A, Ravina B, Glick HA

Neurology.. 2002 July 959 (1):103-8. Epub 1900 01 01.

Randomized, placebo-controlled, parallel group versus crossover study designs for the study of dementia in Parkinson's disease.

Putt ME, Ravina B

Controlled clinical trials. 2002 April 23 (2):111-26. Epub 1900 01 01.

Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safety.

Simuni T, Jaggi JL, Mulholland H, Hurtig HI, Colcher A, Siderowf AD, Ravina B, Skolnick BE, Goldstein R, Stern MB, Baltuch GH

Journal of neurosurgery.. 2002 April 96 (4):666-72. Epub 1900 01 01.

MR findings in subacute combined degeneration of the spinal cord: a case of reversible cervical myelopathy.

Ravina B, Loevner LA, Bank W

AJR. American journal of roentgenology.. 2000 March 174 (3):863-5. Epub 1900 01 01.

Speech disfuency and the structure of knowledge

Schachter, S.; Christenfeld, N.; Ravina, B.; Bilous, F.;.

Journal of Personality and Social Psychology. 1991; 60: 362-367.

Neuroprotection in Parkinson's Disease: An Elusive Goal

Biglan, K.; Ravina, B.;.

Seminars in Neurology. .

Practice Parameter: Evaluation and Treatment of Depression, Psychosis and Dementia in Parkinson's Disease

Miyasaki, J.; Shannon, K.; Voon, V.; Ravina, B.; Kleiner-Fisman, G.;.

Neurology. .

A Phase II, Randomized, Double Blind, Futility Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson's Disease

NET-PD Investigators (Ravina, B.-S.C.;.

Neurology. .

Diagnostic Criteria for Psychosis in Parkinson's Disease: Report of an NINDS/NIMH Work Group

Ravina, B.; Marder, K.; Fernandez, H.H.; Friedman, J.H.; McDonald, W.M.;.

Mov Disord. .

Long Term Understanding of Study Information in Clinical Research Participants

Ravina, B.; Swearingen, C.; Elm, J.J.; Kamp, C.; Kieburtz, K.; Kim, S.;.

Clin Trials. .

Books

The Phase II Futility Clinical Trial Design. (2007)

Chapter: Progress in Neurotherapeutics and Neuropsychopharmacology

Authors: Ravina B., Palesch Y.

Publisher: Cambridge University Press 2007

Biomarker in Parkinson's disease (2007)

Chapter: Parkinson's disease Diagnosis and Clinical Management.

Authors: Dorsey R., Ravina B.

Publisher: Demos Medical Publishing, Inc 2007

Progress in Neurotherapeutics and Neuropsychopharmacology (2007)

Chapter: Futility Clinical Trials in Neurology

Authors: Ravina B, Palesch Y, Tilley BC

Publisher: Cambridge University Press 2007

Movement Disorders (2002)

Chapter: Clinical Neurology of the Older Adult

Authors: Ravina B., Hurtig H

Publisher: Lippincott Williams & Wilkins, Philadelphia 2002

Conn's Current Therapy (2001)

Chapter: Parkinson' Disease

Authors: Ravina B., Stern MB

Publisher: WB Saunders Company 2001