Skip to content
Janice Spence, Ph.D.

Janice Spence, Ph.D.

About Me

Faculty Appointments

Adjunct Assistant Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Microbiology, University of Rochester Medical Center 2001 - 2007

Education

PhD | University of Rochester School of Medicine & Dentistry. Microbiology. 2001

MS | Michigan State Univ. Clinical Laboratory Science. 1981

BS | Michigan State Univ. Medical Technology. 1976

Awards

University of Rochester Medical Center Developmental Grant. 2005

Melvin A. Hare Award for Excellence in Research. 2001

American Society for Microbiology Student Travel Grant. 1995

Melvin A. Hare Award for Excellence in Teaching. 1995

Research

I am working in the laboratory of W. Richard Burack, M.D., Ph.D, Director of the Hematopathology Department of Strong Memorial Hospital. Research goals include the development and validation of novel approaches to the diagnosis of hematopoietic malignancies, with special emphasis on lymphomas. Unli...
I am working in the laboratory of W. Richard Burack, M.D., Ph.D, Director of the Hematopathology Department of Strong Memorial Hospital. Research goals include the development and validation of novel approaches to the diagnosis of hematopoietic malignancies, with special emphasis on lymphomas. Unlike leukemias, in which genetic aberrations generate fusion proteins with mixed regulation and functionality, the characteristic genetic lesion in non-Hodgkins lymphomas involve gene dysregulation through their chromosomal translocation into the IG and TCR regions, which are highly expressed in lymphocytes. Many of these translocations are balanced, which prevents their identification through CGH array methodologies and requires genetic karyotyping and/or FISH for diagnosis, assays which are technically sophisticated. Our approach is two-fold. First, we are developing diagnostic assays based on relatively simple technologies that can be used to identify the common balanced translocations associated with non-Hodgkins lymphomas, suitable for use in a wide-range of diagnostic settings. Second, we are looking to identify a large number of chromosomal markers in lymphomas that will allow for the sub-categorization of these malignancies with regard to clinical outcomes and therapeutic responses. This exploratory approach is based on a novel use of array technologies, using custom oligo arrays to analyze labeled primer extension products which initiate within the well-characterized IG/TCR locations. This use of primer extension products as the analyte allows for the identification of normal gene regions translocated into highly expressed sites, adding the ability to determine spatial proximity to standard CGH arrays.

Publications

Journal Articles

PCR assays detect B-lymphocyte clonality in formalin-fixed, paraffin-embedded specimens of classical hodgkin lymphoma without microdissection.

Burack WR, Laughlin TS, Friedberg JW, Spence JM, Rothberg PG

American journal of clinical pathology.. 2010 July 134 (1):104-11. Epub 1900 01 01.

Laboratory maintenance of Neisseria gonorrhoeae.

Spence JM, Wright L, Clark VL

Current protocols in microbiology.. 2008 February Chapter 4 :Unit 4A.1. Epub 1900 01 01.

cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae.

Isabella V, Wright LF, Barth K, Spence JM, Grogan S, Genco CA, Clark VL

Microbiology.. 2008 January 154 (Pt 1):226-39. Epub 1900 01 01.

L12 enhances gonococcal transcytosis of polarized Hec1B cells via the lutropin receptor.

Spence JM, Tyler RE, Domaoal RA, Clark VL

Microbial pathogenesis.. 2002 March 32 (3):117-25. Epub 1900 01 01.

Role of ribosomal protein L12 in gonococcal invasion of Hec1B cells.

Spence JM, Clark VL

Infection and immunity.. 2000 September 68 (9):5002-10. Epub 1900 01 01.

A proposed role for the lutropin receptor in contact-inducible gonococcal invasion of Hec1B cells.

Spence JM, Chen JC, Clark VL

Infection and immunity.. 1997 September 65 (9):3736-42. Epub 1900 01 01.

Characterization of a polyvalent antibody directed against the IgG Fc receptor of human mononuclear phagocytes.

Anderson CL, Spence JM, Edwards TS, Nusbacher J

The Journal of immunology : official journal of the American Association of Immunologists.. 1985 January 134 (1):465-70. Epub 1900 01 01.