Thomas A. Gasiewicz received his B.S. in Chemistry from Canisius College and went on to study Toxicology at the University of Rochester, where he received his PhD in 1977.
Receptor-mediated Modulation of Gene Expression and Association with Biological and Toxic Responses
While genetics is known to influence the initiation, progression, and outcome of a variety of human diseases including cancer, it is clear that these are also influenced to a great extent by a number of other factors. These include, for example, exposure to chemicals in the environment, diet and aging.
The overall goal of the research in this laboratory is to determine how certain chemicals and substances in the diet influence, in both a positive and negative manner, the processes that influence the progression and outcomes of disease.
By understanding the molecular mechanisms by which these factors act, we will also be providing information that can be used in the design of tools for more effective diagnosis and treatment of these diseases.
BS | Canisius College
PhD | Univ Rochester Sch Med/Dent
Paper of the Year, Immunotoxicology Specialty Section, Society of Toxicology, 2005
Best Paper in Toxicology and Applied Pharmacology, 1998
University of Rochester, School of Medicine, Alumni Award for Excellence in Graduate Education
1989 - 1990
Visiting Associate Professor, Department of Pharmacology, Stanford University
1987 - 1990
International Life Sciences Institute Research Foundation Award
1977 - 1980
National Institutes of Health Postdoctoral Fellowship Award
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Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C. "Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2?/C-MYC axis under hypoxia." Oncogene.. 2016 Sep 15; 35(37):4866-80. Epub 2016 Mar 14.
Unnisa Z, Singh KP, Henry EC, Donegan CL, Bennett JA, Gasiewicz TA. "Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells." Stem cells international. 2016 2016:4536187. Epub 2016 Jun 16.
Moses MA, Henry EC, Ricke WA, Gasiewicz TA. "The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model." Cancer prevention research.. 2015 Mar 0; 8(3):249-57. Epub 2015 Jan 20.
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Taking On Environmental Agents