Thomas A. Gasiewicz, Ph.D.

Thomas A. Gasiewicz, Ph.D.

Contact Information

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box EHSC
Rochester, NY 14642

Administrative: (585) 275-6728

Professional Bio

Thomas A. Gasiewicz received his B.S. in Chemistry from Canisius College and went on to study Toxicology at the University of Rochester, where he received his PhD in 1977.

Research Bio

Receptor-mediated Modulation of Gene Expression and Association with Biological and Toxic Responses

While genetics is known to influence the initiation, progression, and outcome of a variety of human diseases including cancer, it is clear that these are also influenced to a great extent by a number of other factors. These include, for example, exposure to chemicals in the environment, diet and aging.

The overall goal of the research in this laboratory is to determine how certain chemicals and substances in the diet influence, in both a positive and negative manner, the processes that influence the progression and outcomes of disease.
By understanding the molecular mechanisms by which these factors act, we will also be providing information that can be used in the design of tools for more effective diagnosis and treatment of these diseases.

Awards & Honors (Local)

Paper of the Year, Immunotoxicology Specialty Section, Society of Toxicology, 2005 2005
Best Paper in Toxicology and Applied Pharmacology, 1998 1999
University of Rochester, School of Medicine, Alumni Award for Excellence in Graduate Education 1998
Visiting Associate Professor, Department of Pharmacology, Stanford University 1989 - 1990
International Life Sciences Institute Research Foundation Award 1987 - 1990
National Institutes of Health Postdoctoral Fellowship Award 1977 - 1980

Recent Journal Articles

Showing the 5 most recent journal articles. 123 available »

Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C. "Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2?/C-MYC axis under hypoxia." Oncogene. 2016 35(37):4866-80. Epub 2016 Mar 14.
Unnisa Z, Singh KP, Henry EC, Donegan CL, Bennett JA, Gasiewicz TA. "Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells." Stem cells international. 2016 2016:4536187. Epub 2016 Jun 16.
Moses MA, Henry EC, Ricke WA, Gasiewicz TA. "The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model." Cancer prevention research. 2015 8(3):249-57. Epub 2015 Jan 20.
Bennett JA, Singh KP, Unnisa Z, Welle SL, Gasiewicz TA. "Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells." PloS one. 2015 10(7):e0133791. Epub 2015 Jul 24.
Bhat R, Adam AT, Lee JJ, Gasiewicz TA, Henry EC, Rotella DP. "Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors." Bioorganic & medicinal chemistry letters. 2014 24(10):2263-6. Epub 2014 Apr 04.

Current Appointments

Professor - Department of Environmental Medicine (SMD) - Primary


PhD | Toxicology | Univ Rochester Sch Med/Dent1977
BS | Chemistry | Canisius College1972