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Thomas A. Gasiewicz, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-6728

Research Labs

Biography

Professional Background

Thomas A. Gasiewicz received his B.S. in Chemistry from Canisius College and went on to study Toxicology at the University of Rochester, where he received his PhD in 1977.

Research

Receptor-mediated Modulation of Gene Expression and Association with Biological and Toxic Responses

While genetics is known to influence the initiation, progression, and outcome of a variety of human diseases including cancer, it is clear that these are also influenced to a great extent by a number of other factors. These include, for example, exposure to chemicals in the environment, diet and aging.

The overall goal of the research in this laboratory is to determine how certain chemicals and substances in the diet influence, in both a positive and negative manner, the processes that influence the progression and outcomes of disease.
By understanding the molecular mechanisms by which these factors act, we will also be providing information that can be used in the design of tools for more effective diagnosis and treatment of these diseases.

Credentials

Faculty Appointments

Education

1972
BS | Canisius College
Chemistry

1977
PhD | Univ Rochester Sch Med/Dent
Toxicology

Awards

2005
Paper of the Year, Immunotoxicology Specialty Section, Society of Toxicology, 2005

1999
Best Paper in Toxicology and Applied Pharmacology, 1998

1998
University of Rochester, School of Medicine, Alumni Award for Excellence in Graduate Education

1989 - 1990
Visiting Associate Professor, Department of Pharmacology, Stanford University

1987 - 1990
International Life Sciences Institute Research Foundation Award

1977 - 1980
National Institutes of Health Postdoctoral Fellowship Award

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Publications

Journal Articles

9/15/2016
Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C. "Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2?/C-MYC axis under hypoxia." Oncogene.. 2016 Sep 15; 35(37):4866-80. Epub 2016 Mar 14.

2016
Unnisa Z, Singh KP, Henry EC, Donegan CL, Bennett JA, Gasiewicz TA. "Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells." Stem cells international. 2016 2016:4536187. Epub 2016 Jun 16.

3/2015
Moses MA, Henry EC, Ricke WA, Gasiewicz TA. "The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model." Cancer prevention research.. 2015 Mar 0; 8(3):249-57. Epub 2015 Jan 20.

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Videos

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Taking On Environmental Agents