Richard E. Waugh, Ph.D.

Richard E. Waugh, Ph.D.

Contact Information

University of Rochester
500 Joseph C. Wilson Blvd.
Box 270168
Rochester, NY 14611

Journal Articles

Showing all 90 journal articles available.

2016 Jun
Svetina S, Kokot G, Kebe TŠ, Žekš B, Waugh RE. "A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation." Biomechanics and modeling in mechanobiology. 2016 Jun; 15(3):745-58. Epub 2015 Sep 16.
2016 Jun
Marsh G, Waugh RE. "A simple approach for bioactive surface calibration using evanescent waves." Journal of microscopy. 2016 Jun; 262(3):245-51. Epub 2015 Dec 21.
2015 Dec 22
Hughes AD, Marsh G, Waugh RE, Foster DG, King MR. "Halloysite Nanotube Coatings Suppress Leukocyte Spreading." Langmuir : the ACS journal of surfaces and colloids. 2015 Dec 22; 31(50):13553-60. Epub 2015 Dec 09.
2015 Sep 22
Cinar E, Zhou S, DeCourcey J, Wang Y, Waugh RE, Wan J. "Piezo1 regulates mechanotransductive release of ATP from human RBCs." Proceedings of the National Academy of Sciences of the United States of America. 2015 Sep 22; 112(38):11783-8. Epub 2015 Sep 08.
2015 Sep
Beste MT, Lomakina EB, Hammer DA, Waugh RE. "Immobilized IL-8 Triggers Phagocytosis and Dynamic Changes in Membrane Microtopology in Human Neutrophils." Annals of biomedical engineering. 2015 Sep; 43(9):2207-19. Epub 2015 Jan 13.
2015 Jun 9
Kim AR, Olsen JL, England SJ, Huang YS, Fegan KH, Delgadillo LF, McGrath KE, Kingsley PD, Waugh RE, Palis J. "Bmi-1 Regulates Extensive Erythroid Self-Renewal." Stem cell reports. 2015 Jun 9; 4(6):995-1003. Epub 2015 May 28.
2014 Sep 16
Lomakina EB, Marsh G, Waugh RE. "Cell surface topography is a regulator of molecular interactions during chemokine-induced neutrophil spreading." Biophysical journal. 2014 Sep 16; 107(6):1302-12.
2014 Jul 21
Chung HH, Chan CK, Khire TS, Marsh GA, Clark A, Waugh RE, McGrath JL. "Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling." Lab on a chip. 2014 Jul 21; 14(14):2456-68.
2014 Apr 15
Waugh RE. "Forty-percent area strain in red cell membranes?-Doubtful." Biophysical journal. 2014 Apr 15; 106(8):1834-5.
Sanchez-Lockhart M, Rojas AV, Fettis MM, Bauserman R, Higa TR, Miao H, Waugh RE, Miller J. "T cell receptor signaling can directly enhance the avidity of CD28 ligand binding." PloS one. 2014 9(2):e89263. Epub 2014 Feb 24.
2013 Dec
Gaborski TR, Sealander MN, Waugh RE, McGrath JL. "Dynamics of adhesion molecule domains on neutrophil membranes: surfing the dynamic cell topography." European biophysics journal : EBJ. 2013 Dec; 42(11-12):851-5. Epub 2013 Oct 10.
2013 Apr
Waugh RE, Huang YS, Arif BJ, Bauserman R, Palis J. "Development of membrane mechanical function during terminal stages of primitive erythropoiesis in mice." Experimental hematology. 2013 Apr; 41(4):398-408.e2. Epub 2012 Nov 30.
2013 Feb 21
Marsh G, Waugh RE. "Quantifying the mechanical properties of the endothelial glycocalyx with atomic force microscopy." Journal of visualized experiments : JoVE. 2013 Feb 21; (72):e50163. Epub 2013 Feb 21.
2012 Jul 2
Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. "Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels." The Journal of experimental medicine. 2012 Jul 2; 209(7):1349-62. Epub 2012 Jun 18.
2012 Jun 26
Baker CM, Comrie WA, Hyun YM, Chung HL, Fedorchuk CA, Lim K, Brakebusch C, McGrath JL, Waugh RE, Meier-Schellersheim M, Kim M. "Opposing roles for RhoH GTPase during T-cell migration and activation." Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun 26; 109(26):10474-9. Epub 2012 Jun 11.
2011 Sep
Gregoire S, Xiao J, Silva BB, Gonzalez I, Agidi PS, Klein MI, Ambatipudi KS, Rosalen PL, Bauserman R, Waugh RE, Koo H. "Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces." Applied and environmental microbiology. 2011 Sep; 77(18):6357-67. Epub 2011 Jul 29.
2010 Dec 1
Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH. "LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ." The Journal of immunology : official journal of the American Association of Immunologists. 2010 Dec 1; 185(11):7057-66. Epub 2010 Oct 29.
2010 Jun 1
Lomakina EB, Waugh RE. "Signaling and Dynamics of Activation of LFA-1 and Mac-1 by Immobilized IL-8." Cellular and molecular bioengineering. 2010 Jun 1; 3(2):106-116.
2010 Jan
Gaborski TR, Sealander MN, Ehrenberg M, Waugh RE, McGrath JL. "Image correlation microscopy for uniform illumination." Journal of microscopy. 2010 Jan; 237(1):39-50.
2009 Nov 15
Lefort CT, Hyun YM, Schultz JB, Law FY, Waugh RE, Knauf PA, Kim M. "Outside-in signal transmission by conformational changes in integrin Mac-1." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Nov 15; 183(10):6460-8. Epub 2009 Oct 28.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Molecular accessibility in relation to cell surface topography and compression against a flat substrate." Biophysical journal. 2009 Jul 8; 97(1):369-78.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM." Biophysical journal. 2009 Jul 8; 97(1):379-87.
2009 Jul 1
Hyun YM, Chung HL, McGrath JL, Waugh RE, Kim M. "Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Jul 1; 183(1):359-69.
2009 Jan
Waugh RE, Lomakina EB. "Active site formation, not bond kinetics, limits adhesion rate between human neutrophils and immobilized vascular cell adhesion molecule 1." Biophysical journal. 2009 Jan; 96(1):268-75.
2009 Jan
Lomakina EB, Waugh RE. "Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects." Biophysical journal. 2009 Jan; 96(1):276-84.
Lomakina E, Knauf PA, Schultz JB, Law FY, McGraw MD, Waugh RE. "Activation of human neutrophil Mac-1 by anion substitution." Blood cells, molecules & diseases. 2009 42(3):177-84. Epub 2009 Feb 25.
2008 Nov 15
Gaborski TR, Clark A, Waugh RE, McGrath JL. "Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils." Biophysical journal. 2008 Nov 15; 95(10):4934-47. Epub 2008 Aug 08.
2008 Nov
Kaba NK, Schultz J, Law FY, Lefort CT, Martel-Gallegos G, Kim M, Waugh RE, Arreola J, Knauf PA. "Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils." American journal of physiology. Cell physiology. 2008 Nov; 295(5):C1454-63. Epub 2008 Oct 01.
2008 Aug
Butler J, Mohandas N, Waugh RE. "Integral protein linkage and the bilayer-skeletal separation energy in red blood cells." Biophysical journal. 2008 Aug; 95(4):1826-36. Epub 2008 Apr 04.
2006 Oct
Lomakina EB, Waugh RE. "Dynamics of increased neutrophil adhesion to ICAM-1 after contacting immobilized IL-8." Annals of biomedical engineering. 2006 Oct; 34(10):1553-63. Epub 2006 Sep 20.
2006 Feb
Hammer DA, Waugh RE. "Teaching cellular engineering." Annals of biomedical engineering. 2006 Feb; 34(2):253-6. Epub 2006 Feb 01.
2004 Dec
Lomakina EB, Spillmann CM, King MR, Waugh RE. "Rheological analysis and measurement of neutrophil indentation." Biophysical journal. 2004 Dec; 87(6):4246-58. Epub 2004 Sep 10.
2004 Dec
Spillmann CM, Lomakina E, Waugh RE. "Neutrophil adhesive contact dependence on impingement force." Biophysical journal. 2004 Dec; 87(6):4237-45. Epub 2004 Sep 10.
2004 May
Svetina S, Kuzman D, Waugh RE, Ziherl P, Zeks B. "The cooperative role of membrane skeleton and bilayer in the mechanical behaviour of red blood cells." Bioelectrochemistry (Amsterdam, Netherlands). 2004 May; 62(2):107-13.
2004 Feb
Kuzman D, Svetina S, Waugh RE, Zeks B. "Elastic properties of the red blood cell membrane that determine echinocyte deformability." European biophysics journal : EBJ. 2004 Feb; 33(1):1-15. Epub 2003 Sep 12.
2004 Feb
Lomakina EB, Waugh RE. "Micromechanical tests of adhesion dynamics between neutrophils and immobilized ICAM-1." Biophysical journal. 2004 Feb; 86(2):1223-33.
2002 Sep
Spillmann C, Osorio D, Waugh R. "Integrin activation by divalent ions affects neutrophil homotypic adhesion." Annals of biomedical engineering. 2002 Sep; 30(8):1002-11.
2001 Nov
Raphael RM, Waugh RE, Svetina S, Zeks B. "Fractional occurrence of defects in membranes and mechanically driven interleaflet phospholipid transport." Physical review. E, Statistical, nonlinear, and soft matter physics . 2001 Nov; 64(5 Pt 1):051913. Epub 2001 Oct 25.
2001 Mar 15
Waugh RE, Mantalaris A, Bauserman RG, Hwang WC, Wu JH. "Membrane instability in late-stage erythropoiesis." Blood. 2001 Mar 15; 97(6):1869-75.
2001 Feb
Tees DF, Waugh RE, Hammer DA. "A microcantilever device to assess the effect of force on the lifetime of selectin-carbohydrate bonds." Biophysical journal. 2001 Feb; 80(2):668-82.
2000 Oct
Murdock RC, Reynolds C, Sarelius IH, Waugh RE. "Adaptation and survival of surface-deprived red blood cells in mice." American journal of physiology. Cell physiology. 2000 Oct; 279(4):C970-80.
1998 Jun
Tsai MA, Waugh RE, Keng PC. "Passive mechanical behavior of human neutrophils: effects of colchicine and paclitaxel." Biophysical journal. 1998 Jun; 74(6):3282-91.
Svetina S, Zeks B, Waugh RE, Raphael RM. "Theoretical analysis of the effect of the transbilayer movement of phospholipid molecules on the dynamic behavior of a microtube pulled out of an aspirated vesicle." European biophysics journal : EBJ. 1998 27(3):197-209.
1997 Jun
Hwang WC, Waugh RE. "Energy of dissociation of lipid bilayer from the membrane skeleton of red blood cells." Biophysical journal. 1997 Jun; 72(6):2669-78.
1997 May
Waugh RE, McKenney JB, Bauserman RG, Brooks DM, Valeri CR, Snyder LM. "Surface area and volume changes during maturation of reticulocytes in the circulation of the baboon." The Journal of laboratory and clinical medicine. 1997 May; 129(5):527-35.
1996 Dec
Waugh RE, Sarelius IH. "Effects of lost surface area on red blood cells and red blood cell survival in mice." The American journal of physiology. 1996 Dec; 271(6 Pt 1):C1847-52.
1996 Sep
Raphael RM, Waugh RE. "Accelerated interleaflet transport of phosphatidylcholine molecules in membranes under deformation." Biophysical journal. 1996 Sep; 71(3):1374-88.
1996 Apr
Tsai MA, Waugh RE, Keng PC. "Cell cycle-dependence of HL-60 cell deformability." Biophysical journal. 1996 Apr; 70(4):2023-9.
1996 Feb
Waugh RE. "Elastic energy of curvature-driven bump formation on red blood cell membrane." Biophysical journal. 1996 Feb; 70(2):1027-35.
1996 Feb
Khodadad JK, Waugh RE, Podolski JL, Josephs R, Steck TL. "Remodeling the shape of the skeleton in the intact red cell." Biophysical journal. 1996 Feb; 70(2):1036-44.
Ostberg, J. R.; Dragone, L. L.; Waugh, R. E.; Ryan, D.; Frelinger, J. G.; Barth, R. K.;. "Disregulated expression of leukosialin (CD43) in the erythroid lineage of transgenic mice results in microcytosis". Transgenics. 1996; 2(3): 41-51. Link
Waugh RE, Hwang WC, Sarelius IH. "Combined use of fluorescence microscopy and micromechanical measurement to assess cell and membrane properties." Pflügers Archiv : European journal of physiology. 1996 431(6 Suppl 2):R271-2.
Tsai MA, Waugh RE, Keng PC. "Changes in HL-60 cell deformability during differentiation induced by DMSO." Biorheology. 1996 33(1):1-15.
Heinrich V, Waugh RE. "A piconewton force transducer and its application to measurement of the bending stiffness of phospholipid membranes." Annals of biomedical engineering. 1996 24(5):595-605.
Waugh RE, Bauserman RG. "Physical measurements of bilayer-skeletal separation forces." Annals of biomedical engineering. 1995 23(3):308-21.
1994 Jun
Tsai MA, Frank RS, Waugh RE. "Passive mechanical behavior of human neutrophils: effect of cytochalasin B." Biophysical journal. 1994 Jun; 66(6):2166-72.
1993 Nov
Tsai MA, Frank RS, Waugh RE. "Passive mechanical behavior of human neutrophils: power-law fluid." Biophysical journal. 1993 Nov; 65(5):2078-88.
1993 Jun
Song J, Waugh RE. "Bending rigidity of SOPC membranes containing cholesterol." Biophysical journal. 1993 Jun; 64(6):1967-70.
1992 Apr
Bozic B, Svetina S, Zeks B, Waugh RE. "Role of lamellar membrane structure in tether formation from bilayer vesicles." Biophysical journal. 1992 Apr; 61(4):963-73.
1992 Apr
Waugh RE, Song J, Svetina S, Zeks B. "Local and nonlocal curvature elasticity in bilayer membranes by tether formation from lecithin vesicles." Biophysical journal. 1992 Apr; 61(4):974-82.
1992 Mar 1
Waugh RE, Narla M, Jackson CW, Mueller TJ, Suzuki T, Dale GL. "Rheologic properties of senescent erythrocytes: loss of surface area and volume with red blood cell age." Blood. 1992 Mar 1; 79(5):1351-8.
Waugh, R. E.;. "Red cell deformability in different vertebrate animals". Clin. Hemorheol. 1992; 12(3): 649-656. Link
1991 Dec 1
Waugh RE. "Reticulocyte rigidity and passage through endothelial-like pores." Blood. 1991 Dec 1; 78(11):3037-42.
Waugh, R. E.; Song, J.;. "Measurements of membrane bending stiffness: contributions from intrinsic monolayer stiffness and monolayer coupling". Periodicum Biologorum. 1991; 93(3): 217-219. Link
1990 Aug
Song J, Waugh RE. "Bilayer membrane bending stiffness by tether formation from mixed PC-PS lipid vesicles." Journal of biomechanical engineering. 1990 Aug; 112(3):235-40.
1990 Apr
Katnik C, Waugh R. "Electric fields induce reversible changes in the surface to volume ratio of micropipette-aspirated erythrocytes." Biophysical journal. 1990 Apr; 57(4):865-75.
1990 Apr
Katnik C, Waugh R. "Alterations of the apparent area expansivity modulus of red blood cell membrane by electric fields." Biophysical journal. 1990 Apr; 57(4):877-82.
1989 May
Waugh RE, Erwin G. "Flexural rigidity of marginal bands isolated from erythrocytes of the newt." The Journal of cell biology. 1989 May; 108(5):1711-6.
1989 Mar
Bo L, Waugh RE. "Determination of bilayer membrane bending stiffness by tether formation from giant, thin-walled vesicles." Biophysical journal. 1989 Mar; 55(3):509-17.
Waugh, R. E.;. "Structural alterations affect the mechanical behavior of erythrocyte membranes". Stud. Biophys. 1989; 134(3): 155-160. Link
1988 Jan
Waugh RE, Agre P. "Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis." The Journal of clinical investigation. 1988 Jan; 81(1):133-41.
1987 Nov 27
Shields M, La Celle P, Waugh RE, Scholz M, Peters R, Passow H. "Effects of intracellular Ca2+ and proteolytic digestion of the membrane skeleton on the mechanical properties of the red blood cell membrane." Biochimica et biophysica acta. 1987 Nov 27; 905(1):181-94.
1987 Sep
Waugh RE, Hochmuth RM. "Mechanical equilibrium of thick, hollow, liquid membrane cylinders." Biophysical journal. 1987 Sep; 52(3):391-400.
1987 Mar
Waugh RE. "Effects of inherited membrane abnormalities on the viscoelastic properties of erythrocyte membrane." Biophysical journal. 1987 Mar; 51(3):363-9.
Hochmuth RM, Waugh RE. "Erythrocyte membrane elasticity and viscosity." Annual review of physiology. 1987 49:209-19.
1986 Aug
Waugh RE, Erwin G, Bouzid A. "Measurement of the extensional and flexural rigidities of a subcellular structure: marginal bands isolated from erythrocytes of the newt." Journal of biomechanical engineering. 1986 Aug; 108(3):201-7.
1986 Jul
Waugh RE. "Effects of 2,3-diphosphoglycerate on the mechanical properties of erythrocyte membrane." Blood. 1986 Jul; 68(1):231-8.
1986 Jul
Waugh RE, Sassi M. "An in vitro model of erythroid egress in bone marrow." Blood. 1986 Jul; 68(1):250-7.
Waugh RE, Hsu LL, Clark P, Clark A. "Analysis of cell egress in bone marrow." Kroc Foundation series. 1984 16:221-36.
Waugh RE. "Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties." Cell motility. 1983 3(5-6):609-22.
1982 Sep
Waugh RE. "Temperature dependence of the yield shear resultant and the plastic viscosity coefficient of erythrocyte membrane. Implications about molecular events during membrane failure." Biophysical journal. 1982 Sep; 39(3):273-8.
1982 Apr
Waugh RE. "Surface viscosity measurements from large bilayer vesicle tether formation. I. Analysis." Biophysical journal. 1982 Apr; 38(1):19-27.
1982 Apr
Waugh RE. "Surface viscosity measurements from large bilayer vesicle tether formation. II. Experiments." Biophysical journal. 1982 Apr; 38(1):29-37.
Waugh, R.; La Celle, P. L.;. "Abnormalities in the membrane material properties of hereditary spherocytes". J. Biomechan. Engr. 1980; 102(33): 240-246. Link
1979 Apr
Waugh R, Evans EA. "Thermoelasticity of red blood cell membrane." Biophysical journal. 1979 Apr; 26(1):115-31.
Lloyd, J. R.; Meuller, T. J.; Waugh, R. E.;. "Experimental observations on the thermal fragility of erythrocytes including the effects of storage and anticoagulant". J. Biomechan. Engr. 1978; 100(3): 223-228. Link
1977 Dec
Evans EA, Waugh R. "Osmotic correction to elastic area compressibility measurements on red cell membrane." Biophysical journal. 1977 Dec; 20(3):307-13.
Evans, E. A.; Waugh, R.;. "Mechano chemistry of closed vesicular membrane systems". J. Coll. Int. Sci. 1977; 60(3): 286-298. Link
1976 Jun
Evans EA, Waugh R, Melnik L. "Elastic area compressibility modulus of red cell membrane." Biophysical journal. 1976 Jun; 16(6):585-95.
Waugh, R.; Evans, E. A.;. "Viscoelastic properties of erythrocyte membranes of different vertebrate animals". Microvascular Res. 1976; 12(3): 291 304. Link