Kelley Suzanne Madden, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-5724

Research Labs

Visit Lab Website

Locations

University of Rochester
500 Joseph C. Wilson Blvd.
Box 270168
Rochester, NY

Biography

Research

Women diagnosed with breast cancer experience considerable psychological stress, but the impact of such stress on tumor progression is not well understood. The overall objective of my research is to identify mechanisms whereby neurohormones released with stress exposure interact with tumor cells and non-tumor stromal cell populations to regulate cancer progression. Our laboratory has discovered that elevated norepinephrine or activation of selective adrenergic receptors can promote tumor progression and metastasis in association with altered fibrillar collagen microstructure, as detected optically in the tumor by multiphoton second harmonic generation (SHG) imaging. One goal of this line of investigation is to determine if stress-induced elevation in metastatic potential can be detect by SHG imaging of the tumor extracellular environment. We have also begun to investigate the novel idea that psychological stress exposure promotes metastasis by modulating tumor release of exosomes, a newly discovered mechanism to promote tumor cell metastasis. Ultimately, this research will lead to new therapeutic options in treating breast cancer patients.

Credentials

Faculty Appointments

Research Associate Professor- Department of Biomedical Engineering (SMD) - Primary

Education

1983
BS | Valparaiso University
Biology

1989
PhD | Univ Rochester Sch Med/Dent
Microbiology

Publications

Journal Articles

1/2017
Madden KS. "Sympathetic neural-immune interactions regulate hematopoiesis, thermoregulation and inflammation in mammals." Developmental and comparative immunology.. 2017 Jan 0; 66:92-97. Epub 2016 Apr 24.

9/1/2016
Ramirez G, Proctor AR, Jung KW, Wu TT, Han S, Adams RR, Ren J, Byun DK, Madden KS, Brown EB, Foster TH, Farzam P, Durduran T, Choe R. "Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy." Biomedical optics express. 2016 Sep 1; 7(9):3610-3630. Epub 2016 Aug 24.

3/2016
Szpunar MJ, Belcher EK, Dawes RP, Madden KS. "Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer." Brain, behavior, and immunity.. 2016 Mar 0; 53:223-233. Epub 2015 Dec 21.

Books & Chapters

2004
Chapter Title: Aging of the autonomic nervous system
Book Title: The Neuroendocrine Immune Network in Ageing
Author List: Bellinger, D.L, K.S. Madden, and D. Lorton
Edited By: R.H. Straub and E. Mocchegiani
Published By: Elsevier Science2004 in Amsterdam

2002
Chapter Title: Psychoneuroimmunology: Interactions between the brain and the immune system
Book Title: Neuropsychiatry, 2nd ed
Author List: Madden, K.S., D.L. Bellinger, and K.D. Ackerman
Edited By: B.S. Fogel, R.B. Schiffer, and S.M. Rao
Published By: Lippincott Williams & Wilkins2002 in Baltimore

2002
Chapter Title: Psychoimmunology Today - Mechanisms mediating the effects of psychological status on the immune system
Book Title: The Psychoimmunology of Cancer, 2nd ed
Author List: Bellinger, D.L., S. ThyagaRajan, D. Lorton, K.S. Madden, L. Tran, and D.L. Felten
Edited By: C.E. Lewis, R.M. O'Brien, and J. Barraclough
Published By: Oxford University Press2002

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