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James P. Corsetti, M.D., Ph.D.

Pathology

Contact Information

Phone Numbers

Office: (585) 275-4907

Fax: (585) 273-3003

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Dr. Corsetti is Medical Director of the Clinical Trials Central Laboratory and Associate Director of the Automated Laboratory and Protein Laboratory.

Research

My current research interests focus on studies of cardiovascular disease risk in human populations using non-traditional statistical approaches, especially as related to risk associations involving novel biomarkers as well as genetic markers. Underlying our approach is the hypothesis that particular blood and genetic risk markers are most efficacious in particular patient subgroups and that, in general, different patient subgroups have different markers of risk. As such, we have recently developed a 3-dimensional graphical exploratory data analysis technique that we call "outcome event mapping" that allows identification of high-risk patient subgroups not constrained by traditional rectilinear approaches to subgroup identification and allowing subgroup identification even in unexpected regions of risk parameter domains. With it, we have demonstrated a high-risk subgroup in post-MI patients based upon high levels of serum C-reactive protein (CRP) and total cholesterol. Interestingly, we have shown the counter-intuitive result that within this subgroup elevated high-density lipoprotein (HDL) cholesterol, the so-called "good cholesterol", is a risk factor for recurrent events, a finding that we ascribe to transformation of the usual anti-inflammatory HDL into pro-inflammatory HDL. We have also been able to adapt outcome event mapping to delineate subgroup-specific risk in association with single-nucleotide polymorphism (SNP) variants. For example, we have shown that a variant of a SNP in the p22phox subunit of NAD(P)H oxidase (an enzyme playing a critical role in generation of reactive oxygen species and thus potentially in the transformation of HDL) is associated with risk along with elevated HDL in this subgroup. We plan future studies to delineate mechanisms involved in elevated HDL-associated risk using outcome event mapping with additional genetic markers together with advanced statistical techniques to elucidate causal pathways; and to fully characterize the physico-chemical nature of changes at the molecular level in HDL mediating transformation of HDL from anti-inflammatory to pro-inflammatory in nature.

Credentials

Faculty Appointments

Specialties

  • Anatomic Pathology and Clinical Pathology - American Board of Pathology
  • Clinical Pathology/Laboratory Medicine

Education

1969
BS | Univ Rhode Island
Chemistry

1971
MA | Harvard University
Physical Chemistry

1980
PhD | Harvard University
Physical Chemistry

1982
MD | Brown Univ Bio/Med Sciences
Medicine

Post-doctoral Training & Residency

06/01/1985 - 06/30/1986
Residency in Pathology at University of Rochester Medical Center

07/01/1982 - 06/30/1986
Residency in Pathology at University of Rochester Medical Center

Awards

2000 - Present
Member, Who's Who in Science and Engineering

Publications

Journal Articles

9/2016
Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. "Data in support of a central role of plasminogen activator inhibitor-2 polymorphism in recurrent cardiovascular disease risk in the setting of high HDL cholesterol and C-reactive protein using Bayesian network modeling." Data in brief.. 2016 Sep 0; 8:98-104. Epub 2016 May 21.

7/2016
Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. "Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation." Atherosclerosis.. 2016 Jul 0; 250:1-8. Epub 2016 Apr 21.

2016
Corsetti JP, Gansevoort RT, Bakker SJ, Dullaart RP. "Apolipoprotein E levels and apolipoprotein E genotypes in incident cardiovascular disease risk in subjects of the Prevention of Renal and Vascular End-stage disease study." Journal of clinical lipidology.. 2016 10(4):842-850. Epub 2016 Mar 12.

Books & Chapters

1999
Chapter Title: Acute Pancreatitis
Book Title: "Diagnostic Strategies for Common Medical Problems"
Author List: Corsetti, JP and Arvan, DA
Edited By: Black ER, Bordlley DR, Tape TG, and Panzer RJ, eds.
Published By: American College of Physicians1999 in Philadelphia

1999
Chapter Title: Acute Viral Hepatitis
Book Title: "Diagnostic Strategies for Common Medical Problems"
Author List: Corsetti JP, and Arvan DA
Edited By: Black ER, Bordlley DR, Tape TG, and Panzer RJ, eds.
Published By: American College of Physicians1999 in Philadelphia

1999
Chapter Title: Hpercalcemia
Book Title: "Diagnostic Strategies for Common Medical Problems"
Author List: Corsetti JP, and Arvan DA
Edited By: Black ER, Bordlley DR, Tape TG, and Panzer RJ, eds.
Published By: American College of Physicians1999 in Philadelphia

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