Robert T. Dirksen, Ph.D.

Robert T. Dirksen, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-4824
Lab: (585) 273-2170
Fax: (585) 273-2652

Journal Articles

Showing all 118 journal articles available.

2015 Nov 3
Pietrangelo L, D'Incecco A, Ainbinder A, Michelucci A, Kern H, Dirksen RT, Boncompagni S, Protasi F. "Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle." Oncotarget. 2015 Nov 3; 6(34):35358-71.
2015 Sep 25
Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. "Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism." The Journal of biological chemistry. 2015 Sep 25; 290(39):23751-65. Epub 2015 Aug 05.
2015 Sep
Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT. "External Dentin Stimulation Induces ATP Release in Human Teeth." Journal of dental research. 2015 Sep; 94(9):1259-66. Epub 2015 Jun 30.
2015 Sep
Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F. "Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death." Anesthesiology. 2015 Sep; 123(3):603-17.
2015 Feb
Lamboley CR, Kake Guena SA, Touré F, Hébert C, Yaddaden L, Nadeau S, Bouchard P, Wei-LaPierre L, Lainé J, Rousseau EC, Frenette J, Protasi F, Dirksen RT, Pape PC. "New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin." The Journal of general physiology. 2015 Feb; 145(2):127-53.
2015 Jan
Ainbinder A, Boncompagni S, Protasi F, Dirksen RT. "Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle." Cell calcium. 2015 Jan; 57(1):14-24. Epub 2014 Nov 15.
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. "Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function." Skeletal muscle. 2015 5:4. Epub 2015 Jan 29.
Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F. "Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice." Skeletal muscle. 2015 5:10. Epub 2015 Apr 18.
Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF. "Regions of ryanodine receptors that influence activation by the dihydropyridine receptor ?1a subunit." Skeletal muscle. 2015 5:23. Epub 2015 Jul 22.
Liu W, Wei-LaPierre L, Klose A, Dirksen RT, Chakkalakal JV. "Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions." eLife. 2015 4Epub 2015 Aug 27.
2014 Nov 4
Yarotskyy V, Dirksen RT. "Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers." Biophysical journal. 2014 Nov 4; 107(9):2027-36.
2014 Nov
Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H. "Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference." Canadian journal of anaesthesia = Journal canadien d'anesthésie. 2014 Nov; 61(11):1040-9. Epub 2014 Sep 05.
2014 Oct 23
Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ. "Cheng et al. reply." Nature. 2014 Oct 23; 514(7523):E14-5.
2014 Oct
Dowling JJ, Lawlor MW, Dirksen RT. "Triadopathies: an emerging class of skeletal muscle diseases." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2014 Oct; 11(4):773-85.
2014 Aug 20
O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. "Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter." Antioxidants & redox signaling. 2014 Aug 20; 21(6):863-79. Epub 2014 Jun 25.
2014 Aug
Wagner LE, Groom LA, Dirksen RT, Yule DI. "Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp." Cell calcium. 2014 Aug; 56(2):96-107. Epub 2014 Jun 06.
2014 Jul 15
Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD. "Enhanced Ca²? influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy." Human molecular genetics. 2014 Jul 15; 23(14):3706-15. Epub 2014 Feb 20.
2014 Jan 1
Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. "Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes." American journal of physiology. Heart and circulatory physiology. 2014 Jan 1; 306(1):H154-9. Epub 2013 Nov 01.
Yarotskyy V, Dirksen RT. "RGK proteins: fashioning muscle with “Rad” new brakes." Channels. 2014 8(4):286-7.
2013 Apr 12
Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. "Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity." The Journal of biological chemistry. 2013 Apr 12; 288(15):10567-77. Epub 2013 Mar 01.
2013 Feb
Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. "Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease." Neuromuscular disorders : NMD. 2013 Feb; 23(2):120-32. Epub 2012 Nov 24.
Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V. "Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants." PloS one. 2013 8(1):e54042. Epub 2013 Jan 07.
Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. "Murine Fig4 is dispensable for muscle development but required for muscle function." Skeletal muscle. 2013 3(1):21. Epub 2013 Sep 01.
Yarotskyy V, Protasi F, Dirksen RT. "Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death." PloS one. 2013 8(10):e77633. Epub 2013 Oct 15.
Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. "Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue." Nature communications. 2013 4:2805.
2012 Jul 18
Yarotskyy V, Dirksen RT. "Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes." Biophysical journal. 2012 Jul 18; 103(2):202-11. Epub 2012 Jul 17.
2012 Jun
Sheu SS, Dirksen RT, Pugh EN. "Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage." The Journal of general physiology. 2012 Jun; 139(6):391-3.
2012 Jun
Wei L, Dirksen RT. "Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies." The Journal of general physiology. 2012 Jun; 139(6):425-34.
2012 Mar 15
Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. "Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel." Human molecular genetics. 2012 Mar 15; 21(6):1312-24. Epub 2011 Dec 02.
2012 Mar
Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF. "Expression of ecto-ATPase NTPDase2 in human dental pulp." Journal of dental research. 2012 Mar; 91(3):261-7. Epub 2011 Dec 14.
2012 Feb
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. "AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation." Nature medicine. 2012 Feb; 18(2):244-51. Epub 2012 Jan 08.
2012 Jan 6
Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. "Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1." Circulation research. 2012 Jan 6; 110(1):59-70. Epub 2011 Nov 10.
Lanner, J.T.; Georgiou, D.K.; Dagnino-Acosta, A.; Ainbinder, A.; Cheng, Q.; Joshi, A.D.; Chen, Z.; Yarotskyy, V.; Oakes, J.M.; Lee, C.S.; Monroe, T.O.; Santillan, A.; Dong, K.; Goodyear, L.; Ismailov II; Rodney, G.G.; Dirksen, R.T.; Hamilton, S.L. "AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation." Nat. Med. 2012; 18: 244-51.
Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT. "Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy." PloS one. 2012 7(11):e49757. Epub 2012 Nov 12.
2011 Nov 15
Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. "Response to "A critical evaluation of cpYFP as a probe for superoxide"." Free radical biology & medicine. 2011 Nov 15; 51(10):1937-40. Epub 2011 Aug 30.
2011 Nov 15
Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V. "Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres." The Journal of physiology. 2011 Nov 15; 589(Pt 22):5361-82. Epub 2011 Oct 03.
2011 Nov
Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. "Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle." American journal of physiology. Cell physiology. 2011 Nov; 301(5):C1128-39. Epub 2011 Aug 17.
2011 Nov
Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. "Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families." Anesthesiology. 2011 Nov; 115(5):938-45.
2011 Sep
Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. "Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Sep; 25(9):3068-78. Epub 2011 Jun 06.
2011 Jun 17
Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. "Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts." The Journal of biological chemistry. 2011 Jun 17; 286(24):21324-9. Epub 2011 Apr 27.
2011 Jan
Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. "Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum." The Journal of general physiology. 2011 Jan; 137(1):43-57. Epub 2010 Dec 13.
Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. "The elusive role of the SPRY2 domain in RyR1." Channels. 2011 5(2):148-60. Epub 2011 Mar 01.
Sheu SS, Dirksen RT, Pugh EN. "The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine." The Journal of general physiology. 2011 138(6):563-7.
2010 Jul
Dirksen RT, Pugh EN. "Emerging questions about the macromolecular machines of muscle." The Journal of general physiology. 2010 Jul; 136(1):3-5.
2010 May 17
Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. "Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels." FEBS letters. 2010 May 17; 584(10):1948-55. Epub 2010 Jan 21.
2010 Mar
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. "Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene." Neuromuscular disorders : NMD. 2010 Mar; 20(3):166-73. Epub 2010 Jan 18.
Boncompagni S, Loy RE, Dirksen RT, Franzini-Armstrong C. "The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging." Aging cell. 2010 9(6):958-70. Epub 2010 Oct 21.
Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT. "Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle." The Journal of general physiology. 2010 136(6):597-613. Epub 2010 Nov 15.
Kimura, K; Lueck, JD; Harvey, PJ; Pace, SM; Ikemoto, N; Casarotto, MG; *Dirksen, RT; and *Dulhunty, AF. "Alternative splicing of RyR1 influences the efficacy of skeletal EC coupling." Cell Calcium. 2009; In Press.
Boncompagni, S; Rossi, AE; Micaroni, M; Beznoussenko, GV; Polishchuk, RS; *Dirksen, RT; and *Protasi, F. "Muscle mitochondria are structurally linked to Ca2+ release units by developmentally regulated tethering structures." Mol. Biol. Cell. 2009; : 1058-1067.
Oestreich, EA; Malik, S; Goonasekera, SA; Blaxall, BC; Kelley, GG; Dirksen, RT; and Smrcka, AV. "Epac and PLC? regulate Ca2+ release in the heart by activation of PKC? and CaMKII." J. Biol. Chem. 2009; 284: 1514-1522.
Lyfenko, AD; Schuhmeier, RP; Avila, G; Melzer, W; and Dirksen, RT. "A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes." 2009; In preparation.
Andronache, Z.; Hamilton, SL; Dirksen, RT; and Melzer, W. "A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ leak in muscle fibers of Y522S RyR1 knock-in mice." Proc. Natl. Acad. Sci. 2009; In Press.
Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Riggiani, C; Dirksen, RT; and Protasi, F. "Anesthetic- and heat-induced sudden death in calsequestrin-1 knockout mice." FASEB J. 2009; In Press.
Fallon, JL; Baker, MR; Loy, RE; Xiong, L; Yang, G; Dirksen, RT; Hamilton, SL; Quiocho, FA. "Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+ calmodulin." Proc. Natl. Acad. Sci. 2009; In Press.
Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lix, X; Dirksen, RT; Thornton, CA. "Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA." 2009; In Revision.
Lyfenko, AD; Schuhmeier, RP; Avila, G; Melzer, W; and Dirksen, RT. "A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes." 2009; In Preparation.
Boncompagni, S.; Rossi, A.E.; Micaroni, M.; Hamilton, S.L.; Dirksen, R.T.; Franzini-Armstrong, C.; Protasi, F. "Characterization and temporal development of cores in a mouse model of malignant hyperthermia." Proc Natl Acad Sci USA. 2009; 106(51): 21996-2001.
Durham, WJ; Aracena-Parks, P; Long, C*; Rossi, AE; Goonasekera, SA; Boncompagni, S; Gilman, CP; Galvan, DL; Baker, M; Shirokova, N; Protasi, P; Dirksen, RT; and Hamilton, S. "RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice." Cell. 2008; 133: 1-13.
Wang, W; Fang, W; Groom, L; Cheng, A; Zhang, W; Liu, J; Wang, X; Li, K; Han, P; Zhang, M; Yin, J; Wang, W; Mattson, MP; Kao, JPY; Lakatta, EG; Sheu, S-S; Ouyang, K; Chen, J; Dirksen, RT; and Cheng, H. "Superoxide flashes in single mitochondria." Cell. 2008; 134: 279-290.
Lyfenko, AD; and Dirksen, RT. "Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on Stim1 and Orai1." J. Physiol. 2008; .
Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Dirksen, RT; Reggiani, C; and Protasi, F. "Heat- and anesthetic-induced malignant hyperthermia in calsequestrin-1 knockout mice." 2008; Submitted.
Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lin, X; Dirksen, RT; and Thornton, CA. "Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA." 2008; Submitted.
Kimura, T; Pace, SM; Wei, L; Beard, NA; Dirksen, RT; and Dulhunty, AF. "A Variable spliced region of the type 1 ryanodine receptor may participate in an interdomain interaction." Biochem. J. 2007; 401: 317-324.
Oestreich, EA; Wang, H*; Malik, S; Kaproth-Joslin, KA; Blaxall, BC; Kelley, GG; Dirksen, RT; and Smrcka, AV. "Epac-mediated Activation of Phospholipase C? Plays a Critical Role in ?-adrenergic Receptor Dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes." J. Biol. Chem. 2007; 282: 5488-5495.
Lyfenko, AD; Ducreux, S; Wang, Y; Xu, L; Zorzato, F; Ferreiro, A; Meissner, G; Treves, S; and Dirksen, RT. "Two central core disease deletions in the C-terminal region of RyR1 alter muscle EC coupling by distinct mechanisms." Hum. Mutat. 2007; 28: 61-68.
Lueck, JD; Mankodi, A; Swanson, MS; Thornton, CA; and Dirksen, RT. "Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy." J. Gen. Physiol. 2007; 129: 79-94.
Rossi, D; De Smet, P; Lyfenko, A; Galli, L; Lorenzini, S; Franci, D; Petrioli, F; Orrico, A; Tegazzin, V; Dirksen, RT; and Sorrentino, V. "A Truncation in the RYR1 Gene Associated with Central Core Lesions in Skeletal Muscle Fibers." J. Med. Genet. 2007; 44: e67.
Lueck, JD; Lungu, C; Mankodi, A; Osborne, RJ; Welle, SL; Dirksen, RT; and Thornton, CA. "Chloride channelopathy in myotonic dystrophy resulting from loss of post-transcriptional regulation for CLCN1." Am. J. Physiol. 2007; 292: C1291-C1297.
Goonasekera, S; Beard, N; Groom, L; Kimura, T; Lyfenko, AF; Rosenfeld, A; Marty, I; Dulhunty, A; and Dirksen, RT. "Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation-contraction coupling." J. Gen. Physiol. 2007; 130: 365-378.
Wheeler, TM; Lueck, JD; Swanson, MS; Dirksen, RT; and Thornton, CA. "Correction of ClC-1 splicing eliminates the chloride channelopathy and myotonia in myotonic dystrophy." J. Clin. Invest. 2007; 117: 3952-3957.
Zvaritch, E; Depreux, F; Kraeva, N; Loy, RE; Goonasekera, SA; Boncompagi, S; Kraev, A; Gramolini, AO; Dirksen, RT; Franzini-Armstrong, C; Seidman, CE; Seidman, JG; and MacLennan, DH. "A Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line." Proc. Natl. Acad. Sci. 2007; 104: 18537-18542.
2006 Jun
Rossi AE, Dirksen RT. "Sarcoplasmic reticulum: the dynamic calcium governor of muscle." Muscle & nerve. 2006 Jun; 33(6):715-31.
2006 Feb
Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. "Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Feb; 20(2):329-30. Epub 2005 Nov 11.
Rosenberg, H.; Dirksen, R.T.;. "Malignant Hyperthermia Susceptibility". GeneReviews. 2006; .
Kannankeril,P.J.; Mitchell,B.M.; Goonasekera,S.A.; Chelu,M.G.; Zhang,W.; Sood,S.; Kearney,D.L.; Danila,C.I.; De Biasi,M.; Wehrens,X.H.; Pautler,R.G.; Roden,D.M.; Taffet,G.E.; Dirksen,R.T.; Anderson,M.E.; Hamilton,S.L.;. "Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy". Proceedings National Academy Sciences United States of America. 2006; 103: 12179-12184.
Kannankeril, PJ; Mitchell, BM; Goonasekera, SA; Chelu, MG; Zhang, W; Sood, S; Kearney, DL; Danila, C; DeBiasi, M; Wehrens, X; Pautler, RG; Roden, DM; Taffet, GE; Dirksen, RT; Anderson, ME; and Hamilton, SL. "Mice with the R176Q Cardiac Ryanodine Receptor Mutation Exhibit Catecholamine-Induced Ventricular Tachycardia and Mild Cardiomyopathy." Proc. Natl. Acad. Sci. 2006; 103: 12179-12184.
Aracena-Parks, P; Goonasekera, SA; Gilman, C; Dirksen, RT; Hidalgo, C; and Hamilton, SL. "Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in RyR1." J. Biol. Chem. 2006; 281: 40354-40368.
2005 Aug 1
Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S. "Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1." Human molecular genetics. 2005 Aug 1; 14(15):2189-200. Epub 2005 Jun 22.
2005 Jul
Avila G, Dirksen RT. "Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function." Cell calcium. 2005 Jul; 38(1):35-44.
Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy." Circulation research. 2005 97(12):1305-13. Epub 2005 Nov 17.
Beutner,G.; Sharma,V.K.; Lin,L.; Ryu,S.Y.; Dirksen,R.T.; Sheu,S.S.;. "Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling". Biochemica Biophysica ACTA. 2005; 1717(1): 1-10. Link
Goonasekera SA, Chen SR, Dirksen RT. "Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6." American journal of physiology. Cell physiology. 2005 289(6):C1476-84. Epub 2005 Jul 27.
2004 Nov
Dirksen RT, Avila G. "Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1." Biophysical journal. 2004 Nov; 87(5):3193-204. Epub 2004 Sep 03.
2004 Oct
Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT. "Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling." American journal of physiology. Cell physiology. 2004 Oct; 287(4):C1094-102. Epub 2004 Jun 16.
2004 Sep 3
Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH. "Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1)." The Journal of biological chemistry. 2004 Sep 3; 279(36):37566-74. Epub 2004 Jun 28.
Lyfenko,A.D.; Goonasekera,S.A.; Dirksen,R.T.;. "Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease". Biochemical Biophysical Research Communications. 2004; 322(4): 1256-1266. Link
2003 Jul
He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. "ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes." The American journal of pathology. 2003 Jul; 163(1):243-51.
2003 Jun 20
Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. "FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes." The Journal of biological chemistry. 2003 Jun 20; 278(25):22600-8. Epub 2003 Apr 17.
2003 Jun
Leuranguer V, Dirksen RT, Beam KG. "Potentiated L-type Ca2+ channels rectify." The Journal of general physiology. 2003 Jun; 121(6):541-50. Epub 2003 May 12.
2003 Apr
Avila G, O'Connell KM, Dirksen RT. "The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease." The Journal of general physiology. 2003 Apr; 121(4):277-86. Epub 2003 Mar 17.
2002 Sep
O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT. "Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes." The Journal of general physiology. 2002 Sep; 120(3):337-47.
2002 Jul
Dirksen RT, Avila G. "Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels?" Trends in cardiovascular medicine. 2002 Jul; 12(5):189-97.
2002 Feb
Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. "Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation." Journal of neurochemistry. 2002 Feb; 80(3):531-8.
Papineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL. "Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1." The Journal of biological chemistry. 2002 277(51):49167-74. Epub 2002 Oct 02.
Dirksen,R.T.;. "Bi-directional coupling between dihydropyridine receptors and ryanodine receptors". Frontiers Bioscience. 2002; 7:d659-70.: d659-d670. Link
Dirksen RT. "Reactive oxygen/nitrogen species and the aged brain: radical impact of ion channel function." Neurobiology of aging. 2002 23(5):837-9; discussion 841-2.
2001 Sep
Avila G, Dirksen RT. "Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor." The Journal of general physiology. 2001 Sep; 118(3):277-90.
2001 May 25
Avila G, O'Connell KM, Groom LA, Dirksen RT. "Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression." The Journal of biological chemistry. 2001 May 25; 276(21):17732-8. Epub 2001 Jan 22.
Avila,G.; O'Brien,J.J.; Dirksen,R.T.;. "Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor". Proceedings National Academy Sciences United States of America. 2001; 98(7): 4215-4220. Link
2000 Apr
Avila G, Dirksen RT. "Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel." The Journal of general physiology. 2000 Apr; 115(4):467-80.
O'Connell,K.M.; Dirksen,R.T.;. "Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes". Journal Physiology. 2000; 529: 647-659. Link
Suda,N.; Dirksen,R.T.; Gonzalez,A.; Beam,K.G.;. "Low serum promotes maturation of excitation-contraction coupling in myotubes". Pflugers Archive. 2000; 439(5): 555-558. Link
1999 Sep
Dirksen RT, Beam KG. "Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling." The Journal of general physiology. 1999 Sep; 114(3):393-403.
1999 Jul 30
Grabner M, Dirksen RT, Suda N, Beam KG. "The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor." The Journal of biological chemistry. 1999 Jul 30; 274(31):21913-9.
Grabner,M.; Dirksen,R.T.; Beam,K.G.;. "Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes". Proceedings National Academy Sciences United States of America. 1998; 95(4): 1903-1908. Link
1997 Sep
Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG. "The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance." Biophysical journal. 1997 Sep; 73(3):1402-9.
1996 Jun
Dirksen RT, Beam KG. "Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes." The Journal of general physiology. 1996 Jun; 107(6):731-42.
1996 Mar 7
Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. "Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor." Nature. 1996 Mar 7; 380(6569):72-5.
1995 Feb
Dirksen RT, Beam KG. "Single calcium channel behavior in native skeletal muscle." The Journal of general physiology. 1995 Feb; 105(2):227-47.
Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. "Autonomic modulation of action potential and tension in guinea pig papillary muscles." European journal of pharmacology. 1994 271(2-3):309-17.
1993 Apr
Fujita Y, Mynlieff M, Dirksen RT, Kim MS, Niidome T, Nakai J, Friedrich T, Iwabe N, Miyata T, Furuichi T. "Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain." Neuron. 1993 Apr; 10(4):585-98.
Mori,Y.; Niidome,T.; Fujita,Y.; Mynlieff,M.; Dirksen,R.T.; Beam,K.G.; Iwabe,N.; Miyata,T.; Furutama,D.; Furuichi,T.;. "Molecular diversity of voltage-dependent calcium channel". Annals New York Academy Sciences. 1993; 707:87-108.: 87-108. Link
Arreola,J.; Dirksen,R.T.; Shieh,R.C.; Williford,D.J.; Sheu,S.S.;. "Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes". American Journal of Physiology (Cell Physiology). 1991; 261(2 Pt 1): C393-C397. Link
Sheu,S.S.; Sharma,V.K.; Korth,M.; Moscucci,A.; Dirksen,R.T.; Jou,M.J.;. "Receptor-mediated inotropic effect in heart. Role of sodium-calcium exchange". Annals New York Academy Sciences. 1991; 639:398-407.: 398-407. Link
1990 May
Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS. "Antipsychotic pimozide is a potent Ca2+ channel blocker in heart." Molecular pharmacology. 1990 May; 37(5):752-7.
Dirksen,R.T.; Sheu,S.S.;. "Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C". American Journal of Physiology(Heart Circulation Physiology). 1990; 258(3 Pt 2): H907-H911. Link
1986 Nov 15
Reichman M, Dirksen R, Abood LG, Gala D. "Effects of the affinity ligands 14-beta-chloroacetylnaltrexone and 14-beta-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain." Biochemical pharmacology. 1986 Nov 15; 35(22):3995-8.


Rosenberg, H; and Dirksen, RT. "Malignant hyperthermia Susceptibility is: GeneReviews at GeneTests.". Medical Genetics Information Resource [database online]. Seattle: University of Washington, 2006. Updated 2010.
Dirksen RT and Avila G. "Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.". Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease. XH Wehrens and AR Marks. : Springer, 2005. 229-242