Barbara H. Iglewski, Ph.D.

Barbara H. Iglewski, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Professional Bio

Dr. Barbra Iglewski is Professor of Microbiology and Immunology and Director of International Programs at the University of Rochester Medical Center. She was the Chair of the Department of Microbiology and Immunology from 1986-2009 and the Vice Provost for Research and Graduate Education at the University of Rochester from 1995-1998.

Research Bio

Dr. Iglewski has made many important contributions to the field of Pathogenic Microbiology and is best known for her elucidation of the molecular mechanism of action of Pseudomonas toxin A, the discovery of various other toxins and exoenzymes including the first type 3 secreted Pseudomonas toxin (exo S) and her landmark discovery that a type I quorum sensing system was a global regulator of virulence in a human pathogen. Dr. Iglewski has published over 150 research papers and book chapters and served as an editor of a number of books including the Encyclopedia of Microbiology. Dr. Iglewski is recognized by the Institute of Scientific Information as a highly cited scientist.

This group comprises less than 0.5% of all publishing researchers. Her current research projects, supported by a merit award from the NIH, focus on the regulation of virulence and biofilm development in Pseudomonas aeruginosa.

Patents

An Autoinducer Molecule

United States Serial NO.: 08/104,487
Filed Date: August 9, 1993
Title: Autoinducer Molecule
Invented by: Barbara Iglewski, Luciano Passador, James Pearson, Kendall Gray, Kenneth Tucker, Everett Greenberg, Anatole Eberhard
An Autoinducer Molecule

United States Serial NO.: 08/456,864
Filed Date: June 1, 1995
Title: Autoinducer Molecule
Invented by: Barbara Iglewski, Luciano Passador, James Pearson, Kendall Gray, Kenneth Tucker, Everett Greenberg, Anatole Eberhard
An Autoinducer Molecule

United States Serial NO.: 08/456,864
Filed Date: June 1, 1995
Title: Autoinducer Molecule
Invented by: Barbara Iglewski, Luciano Passador, James Pearson, Kendall Gray, Kenneth Tucker, Everett Greenberg, Anatole Eberhard
An Autoinducer Molecule

United States Serial NO.: 09/541,873
Filed Date: April 3, 2000
Title: Autoinducer Molecule
Invented by: Barbara Iglewski, Luciano Passador, James Pearson, Kendall Gray, Kenneth Tucker, Everett Greenberg, Anatole Eberhard
An Autoinducer Molecule

United States Serial NO.: 11/030,569
Filed Date: January 5, 2005
Title: Autoinducer Molecule
Invented by: Barbara Iglewski, Luciano Passador, James Pearson, Kendall Gray, Kenneth Tucker, Everett Greenberg, Anatole Eberhard
Novel Autoinducer Molecules and Uses Therefore (Quinoline Signaling in the Cell-to-Cell Communication)

United States Serial NO.: 09/945,325
Filed Date: August 31, 2001
Title: Novel Autoinducer Molecules and Uses Therefor
Invented by: Barbara Iglewski, Pesci Everett, Jared Milbank, James Pearson, Andrew Kende, Everett Greenberg
Novel Autoinducer Molecules and Uses Therefore (Quinoline Signaling in the Cell-to-Cell Communication)

United States Serial NO.: 10/844,037
Filed Date: May 11, 2004
Title: Autoinducer Molecules and Uses Therefor
Invented by: Barbara Iglewski, Pesci Everett, Jared Milbank, James Pearson, Andrew Kende, Everett Greenberg

Awards & Honors (National)

NIH Health Merit Award R37 2001 - 2010
Fellow, American Academy of Microbiology 1986
Alice Evans Award, American Society for Microbiology 1994
John W. Bullard Lecturer; Uniformed Services University of Health Sciences 1992

Awards & Honors (Local)

Lifetime Mentor Award | URMC 2009
Susan B. Anthony, Lifetime Achievement Award 2001
Arthur Kornberg, Research Award 1999
Honorary Lifetime Member - Sigma Delta Epsilon 1987

Recent Journal Articles

Showing the 5 most recent journal articles. 153 available »

2009 Oct
Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. "Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa." Infection and immunity.. 2009 Oct; 77(10):4446-54. Epub 2009 Aug 03.
2008
Wagner VE, Iglewski BH. "P. aeruginosa Biofilms in CF Infection." Clinical reviews in allergy & immunology. 2008 35(3):124-34.
2007 Nov
Morici LA, Carterson AJ, Wagner VE, Frisk A, Schurr JR, Höner zu Bentrup K, Hassett DJ, Iglewski BH, Sauer K, Schurr MJ. "Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner." Journal of bacteriology.. 2007 Nov; 189(21):7752-64. Epub 2007 Aug 31.
2007 Aug
Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG. "Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa." Infection and immunity.. 2007 Aug; 75(8):3780-90. Epub 2007 May 25.
2007 Jun
Li LL, Malone JE, Iglewski BH. "Regulation of the Pseudomonas aeruginosa quorum-sensing regulator VqsR." Journal of bacteriology.. 2007 Jun; 189(12):4367-74. Epub 2007 Apr 20.

Current Appointments

Professor Emeritus - Department of Microbiology and Immunology (SMD) - Primary

Education

PhD | Microbiology, All Other | Penn State University1964
MS | Microbiology, All Other | Penn State University1962
BS | Biology | Allegheny College1960