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Barbara H. Iglewski, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Faculty Appointments

Biography

Professional Background

Dr. Barbra Iglewski is Professor of Microbiology and Immunology and Director of International Programs at the University of Rochester Medical Center. She was the Chair of the Department of Microbiology and Immunology from 1986-2009 and the Vice Provost for Research and Graduate Education at the University of Rochester from 1995-1998.

Research

Dr. Iglewski has made many important contributions to the field of Pathogenic Microbiology and is best known for her elucidation of the molecular mechanism of action of Pseudomonas toxin A, the discovery of various other toxins and exoenzymes including the first type 3 secreted Pseudomonas toxin (exo S) and her landmark discovery that a type I quorum sensing system was a global regulator of virulence in a human pathogen. Dr. Iglewski has published over 150 research papers and book chapters and served as an editor of a number of books including the Encyclopedia of Microbiology. Dr. Iglewski is recognized by the Institute of Scientific Information as a highly cited scientist. This group comprises less than 0.5% of all publishing researchers. Her current research projects, supported by a merit award from the NIH, focus on the regulation of virulence and biofilm development in Pseudomonas aeruginosa.

Credentials

Education

1960
BS | Allegheny College
Biology

1962
MS | Penn State University
Microbiology, All Other

1964
PhD | Penn State University
Microbiology, All Other

Awards

2009
Lifetime Mentor Award
Sponsor: URMC

2001 - 2010
NIH Health Merit Award R37

2001
Susan B. Anthony, Lifetime Achievement Award

1999
Arthur Kornberg, Research Award

1994
Alice Evans Award, American Society for Microbiology

1992
John W. Bullard Lecturer; Uniformed Services University of Health Sciences

1987
Honorary Lifetime Member - Sigma Delta Epsilon

1986
Fellow, American Academy of Microbiology

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Patents

Patent Title: Methods of Treating or Preventing an Infectious Disease Using an Immunogenic Conjugate of a Gram-Negative Bacterial Autoinducer Molecule
Patent #: 7,384,639
Issue Date: Jun 10, 2008
Country: United States
Invented By: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

Patent Title: Methods and Compositions for Controlling Biofilm Development
Patent #: 6,455,031
Issue Date: Sep 24, 2002
Country: United States
Invented By: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Patent Title: Methods and Compositions for Controlling BioFilm Development
Patent #: 7,094,394
Issue Date: Aug 22, 2006
Country: United States
Invented By: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Patent Title: Method for Detecting a Gram-Negative Bacterial Autoinducer Molecule
Patent #: 6,958,219
Issue Date: Oct 25, 2005
Country: United States
Invented By: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

Patent Title: Immunogenic Conjugates of Gram Negative Bacterial Autoinducer Molecules and Antibodies Raised Against the Same
Patent #: 6,395,282
Issue Date: May 28, 2002
Country: United States
Invented By: Barbara H Iglewski, Richard P Phipps

Patent Title: Homoserine Lactones Biofilm Regulating Compounds and Thier Methods of Use.
Patent #: 753,329
Issue Date: Oct 17, 2002
Country: Australia
Invented By: Barbara H Iglewski, James P Pearson

Patent Title: Homoserine Lactones Biofilm Regulating Compounds and Their Methods of Use
Patent #: 2,294.586
Issue Date: Jan 27, 2009
Country: Canada
Invented By: John William Costerton, David G Davies, Everett P Greenberg, Barbara H Iglewski, Matthew R Parsek, James P Pearson

Patent Title: Homoserine Lactones Biofilm Regulating Compounds and Their Methods of Use
Patent #: 0994961
Issue Date: Oct 18, 2006
Country: Europe
Invented By: Barbara H Iglewski, James P Pearson

Patent Title: Autoinducer Molecules and Uses Therefor
Patent #: 7,442,798
Issue Date: Oct 28, 2008
Country: United States
Invented By: Pesci C Everett, Everett P Greenberg, Barbara H Iglewski, Andrew S Kende, Jared B Milbank, James P Pearson

Patent Title: Autoinducer Molecule
Patent #: 6,936,447
Issue Date: Aug 30, 2005
Country: United States
Invented By: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Patent Title: Autoinducer Molecule
Patent #: 6,057,288
Issue Date: May 02, 2000
Country: United States
Invented By: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Patent Title: Autoinducer Molecule
Patent #: 5,591,872
Issue Date: Jan 07, 1997
Country: United States
Invented By: Anatole Eberhard, Kendall M Gray, Everett P Greenberg, Barbara H Iglewski, Luciano Passador, James P Pearson, Kenneth D Tucker

Patent Title: Antibodies Raised Against Immunogenic Conjugates of Gram-Negative Bacterial Autoinducer Molecules
Patent #: 6,713,059
Issue Date: Mar 30, 2004
Country: United States
Invented By: Barbara H Iglewski, Andrew S Kende, James P Pearson, Richard P Phipps, Roger Smith

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Publications

Journal Articles

10/2009
Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. "Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa." Infection and immunity.. 2009 Oct 0; 77(10):4446-54. Epub 2009 Aug 03.

12/2008
Wagner VE, Iglewski BH. "P. aeruginosa Biofilms in CF Infection." Clinical reviews in allergy & immunology.. 2008 Dec 0; 35(3):124-34.

11/2007
Morici LA, Carterson AJ, Wagner VE, Frisk A, Schurr JR, Höner zu Bentrup K, Hassett DJ, Iglewski BH, Sauer K, Schurr MJ. "Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner." Journal of bacteriology.. 2007 Nov 0; 189(21):7752-64. Epub 2007 Aug 31.

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