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Michael John Zuscik, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

The central focus of our research can be divided programmatically into two parts: 1) the study of the contribution of chondrogenesis and chondrocyte differentiation to the process of fracture repair and 2) the study of the behavior of the articular chondrocyte under normal conditions in healthy joints and during pathologic situations such as joint degeneration.

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Research Network

Credentials

Faculty Appointments

  • Associate Professor- Department of Biomedical Engineering (SMD)
  • Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary

Education

1987
BS | Wheeling Jesuit Univ
Physics

1993
PhD | Univ Rochester Sch Med/Dent
Biophysics

1989
MS | Univ Rochester Sch Med/Dent
Biophysics

Awards

2006
Marvin Hoffman Faculty Mentoring Award University of Rochester

2000
Finalist, F. Merlin Bumpus Young Investigator Award Cleveland Clinic Foundation

1987
Physics Departmental Award Wheeling Jesuit University

1987
Rev. Frank R. Haig S.J. Science Award Wheeling Jesuit University

1987
AEN National Jesuit Honor Society Wheeling Jesuit University

1984 - 1987
Laut Honors Scholar Wheeling Jesuit University

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Patents

Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
U.S. Serial #: 13/971,366
Filed: Aug 20, 2013
Invented By: HaniAwad, SusanBukata, RegisO'Keefe, J. EdwardPuzas, RandyRosier, ErikSampson, MichaelZuscik

Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
U.S. Serial #: 13/124,002
Filed: Oct 13, 2009
Invented By: HaniAwad, SusanBukata, RegisO'Keefe, J. EdwardPuzas, RandyRosier, ErikSampson, MichaelZuscik

Publications

Journal Articles

6/5/2008
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene.. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.

5/2008
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. "Regulation of embryonic endochondral ossification by Smurf2." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 May 0; 26(5):704-12.

3/2008
Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. "Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 Mar 0; 23(3):314-25.

Books & Chapters

2006
Chapter Title: Cell and molecular biology in orthopaedics.
Book Title: Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal
Author List: Zuscik MJ, Drissi H, Chen D and Rosier RN
Edited By: Buckwalter JA, Einhorn TA and Simon SR, eds.
Published By: AAOS Press,2006 in Rosemont, IL

2005
Chapter Title: Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis.
Book Title: Molecular Aspects of Medicine
Author List: Drissi H, Zuscik MJ, Rosier RN and O'Keefe RJ
Published By: MAM is Elsevier2005 in Amsterdam, Netherlands

2003
Chapter Title: Altered negative regulation of transforming growth factor-b signaling in scleroderma: Potential involvement of Smurf2 in disease. 48:1779-1780.
Book Title: Athritis and Rheumatism
Author List: Zuscik MJ, Rosier RN and Schwarz EM
Published By: A&R is John Wiley and Sons, Inc.2003 in Hoboken, NJ

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