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Francis Gigliotti, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-5944

Office: (585) 275-5944

Fax: (585) 273-1104

Faculty Appointments

Patient Care Setting



Pediatric infectious diseases, especially infections in the immunocompromised host.


Dr. Gigliotti's research interests are:

1) Pneumocystis carinii pneumonia
2) Infections in the immunocompromised host
3) Inflammatory lung injury
4) Opportunistic infections.

Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromised because of malignancies, AIDS, or congenital immunodeficiency disorders. P. carinii pneumonia also occurs in children who are immunocompromised on the basis of malnutrition; thus the global significance of P. carinii pneumonia is potentially great. However, because this organism is difficult to work with and because it cannot be cultivated outside an animal host, almost nothing is known about its biology.

The focus of Dr. Gigliotti's laboratory is elucidating the immunopathogenesis of P. carinii pneumonia. A major area of investigation relates to studying active and passive immunity to P. carinii. This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia.

The second major area of emphasis is the study of lung injury resulting from immune-mediated inflammation in response to infection with P. carinii. Together with Dr. Terry Wright, we are trying to develop means to manipulate this inflammatory process so as to decrease the morbidity and mortality associated with P. carinii pneumonia. It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia.



AB | West Virginia University

MD | University of Virginia School of Medicine

Post-doctoral Training & Residency

07/01/1980 - 06/30/1983
Fellowship in Pediatric Infectious Diseases at University of Rochester Medical Center

07/01/1978 - 06/30/1980
Residency in Pediatrics at University of Virginia School of Medicine

07/01/1977 - 06/30/1978
Internship in Pediatrics at University of Virginia School of Medicine

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2008 - Present
Best Doctor's in America

2007 - Present
American's Top Pediatricians

Lindsey Distinguished Professorship for Pediatric Research
Sponsor: University of Rochester Medical Center-Department of Pediatrics

Ruth A. Lawrence Faculty Service Award for Research

Elected to American Society for Clinical Investigation

1992 - 1995
Lowell Glasgow Dean's Teaching Scholar

House Staff Teaching Award

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Patent Title: Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
Patent #: 7,815,918
Issue Date: Oct 19, 2010
Country: United States
Invented By: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright

Patent Title: Optimized Antigens of Pneumocystis and Use Thereof
Patent #: 9,512,189
Issue Date: Dec 06, 2016
Country: United States
Invented By: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright

Patent Title: Human Monoclonal Antibodies Against Bacterial Toxins
Patent #: 4,689,299
Issue Date: Aug 25, 1987
Country: United States
Invented By: Francis Gigliotti, Richard A Insel

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Journal Articles

Hoy Z, Wright TW, Elliott M, Malone J, Bhagwat S, Wang J, Gigliotti F. "Combination immunotherapy with passive antibody and sulfasalazine accelerates fungal clearance and promotes the resolution of associated immunopathogenesis." Infection and immunity.. 2019 Oct 14; Epub 2019 Oct 14.

Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F. "Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii." Infection and immunity.. 2017 Apr; 85(4)Epub 2017 Mar 23.

Chemello G, Piccinetti C, Randazzo B, Carnevali O, Maradonna F, Magro M, Bonaiuto E, Vianello F, Radaelli G, Fifi AP, Gigliotti F, Olivotto I. "Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles." Zebrafish.. 2016 Dec; 13(6):495-503. Epub 2016 Aug 10.

Books & Chapters

Chapter Title: Pneumocystis and Other Less Common
Book Title: Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant
Author List: Gigliotti F, Wright TW, Krysan
Published By: Elsevier Saunders 2015 in Philadelphia

Chapter Title: Pneumocystis pneumonia
Book Title: Feigin and Cherry's Textbook of Pediatric Infectious Diseases
Author List: Gigliotti F
Published By: Elsevier Saunders 2015 in Philadelphia

Chapter Title: Pneumocystis Jirovecii
Book Title: Principles and Practice of Pediatric Infectious Diseases
Author List: Gigliotti, F
Published By: Saunders 2015 in Philadelphia